Oral Presentation

doi:10.1590/s1678-77572006000700011

J. Appl. Oral Sci.

2006

DOI: 10.1590/s1678-77572006000700011

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Ion exchange chromatography of monoclonal antibodies: Effect of resin ligand density on dynamic binding capacity

Hardin¹,

Harinarayan²,

Malmquist³

et al. 2009

Journal of Chromatography A

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Dynamic binding capacity (DBC) of a monoclonal antibody on agarose based strong cation exchange resins is determined as a function of resin ligand density, apparent pore size of the base matrix, and protein charge. The maximum DBC is found to be unaffected by resin ligand density, apparent pore size, or protein charge within the tested range. The critical conductivity (conductivity at maximum DBC) is seen to vary with ligand density. It is hypothesized that the maximum DBC is determined by the effective size of the proteins and the proximity to which they can approach one another. Once a certain minimum resin ligand density is supplied, additional ligand is not beneficial in terms of resin capacity. Additional ligand can provide flexibility in designing ion exchange resins for a particular application as the critical conductivity could be matched to the feedstock conductivity and it may also affect the selectivity.

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Ion exchange chromatography of monoclonal antibodies: Effect of resin ligand density on dynamic binding capacity

Hardin¹,

Harinarayan²,

Malmquist³

et al. 2009

Journal of Chromatography A

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Ab initio molecular dynamics simulations of oxygen-deficient centers in pure and Ge-doped silica glasses: Structure and optical properties

Laudernet

Richard

Girard

et al. 2006

Journal of Non-Crystalline Solids

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Oral Presentation

Cited by 2 publications

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Ion exchange chromatography of monoclonal antibodies: Effect of resin ligand density on dynamic binding capacity

Ion exchange chromatography of monoclonal antibodies: Effect of resin ligand density on dynamic binding capacity

Ab initio molecular dynamics simulations of oxygen-deficient centers in pure and Ge-doped silica glasses: Structure and optical properties

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