Oral prednisolone versus non-steroidal anti-inflammatory drugs in the treatment of acute gout: a meta-analysis of randomized controlled trials

Yu, Jie; Lu, Hongyang; Zhou, Jia; Xie, Zhihua; Wen, Chengping; Xu, Zhenghao

doi:10.1007/s10787-018-0442-8

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…25 Statistical heterogeneity was assessed by Cochran’s Q statistic and the I 2 statistic. Similar to our previous studies, 17,26,27 the fixed effects model was used to pool studies when statistical heterogeneity was absent (the I 2 < 50% or Q-p value > 0.1); otherwise, the random effects model was employed. p < 0.05 was considered to indicate a statistically significant difference.…”

Section: Methodsmentioning

confidence: 99%

Risk of epilepsy in rheumatoid arthritis: a meta-analysis of population based studies and bioinformatics analysis

Zhao

Xie

et al. 2020

Therapeutic Advances in Chronic Disease

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Background: An increasing number of studies support an association between rheumatoid arthritis (RA) and brain disorders. This study aims to determine the association between RA and epilepsy. Methods: A comprehensive search of databases in both English and Chinese was performed. Data from the selected studies were extracted and analyzed independently by two authors. Genes associated with epilepsy and RA were also collected and analyzed. Results: We included six nationwide population based studies ( n = 7,094,113 cases in total) for the meta-analysis. The risk of epilepsy was increased in RA patients [risk ratio (RR) = 1.601; 95% confidence interval (CI): 1.089–2.354; p = 0.017; n = 3,803,535 cases] and children born to mothers with RA (RR = 1.475; 95% CI: 1.333–1.633; p < 0.001, n = 3,290,578 cases). Subgroup analysis and meta-regression showed the RR of epilepsy in RA was negatively correlated with age. Furthermore, we found that 433 identified genes in a coexpression network from the hippocampi of 129 epileptic patients were enriched in the RA and related Kyoto Encyclopedia of Genes and Genomes pathways, while 13 genes (mainly related to inflammatory cytokines and chemokines) were identified as potential key genes bridging the RA and epilepsy. Conclusions: Our study, utilizing meta-analysis and bioinformatical data, highlights a close association between epilepsy and RA. Further studies are still warranted to expand these findings, especially for a population that is exposed to RA during fetal and childhood periods.

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Section: Methodsmentioning

confidence: 99%

Risk of epilepsy in rheumatoid arthritis: a meta-analysis of population based studies and bioinformatics analysis

Zhao

Xie

et al. 2020

Therapeutic Advances in Chronic Disease

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“…It is thought that prescription of low-dose prednisolone can be efficient and safer than NSAIDs for treatment of acute arthritis in gout patients. However, there have been no randomized controlled trials aimed at investigating comparative efficacy of glucocorticoids and NSAIDs [44].…”

Section: Glucocorticoidsmentioning

confidence: 99%

Prophylaxis of Acute Arthritis at Initiation of Urate-Lowering Therapy in Gout Patients

Елисеев¹,

Чикина²,

Насонов³

2020

Recent Advances in Gout

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During the first months after the initiation of urate-lowering therapy in gout patients, the risk of exacerbation of arthritis considerably rises, which often results in discontinuation of the prescribed therapy by patients. The main way to avoid this risk is preventive prescription of colchicine, NSAIDs or glucocorticoids. Such prophylaxis of acute arthritis has been specified in a large number of the latest editions of various national and international guidelines; however, this tactics is rarely used in practice. The chapter includes the most significant studies on this problem.

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“…Считается, что назначение преднизолона в низких дозах может быть эффективным и более безопасным, по сравнению с НПВП, для лечения острого приступа артрита у больных подагрой. Однако РКИ, направленных на изучение сравнительной эффективности ГК и НПВП, не проводилось [48].…”

Section: нестероидные противовоспалительные препаратыunclassified

Prevention of arthritis attacks in the use of urate-lowering therapy in patients with gout

Чикина¹

2019

Naučno-praktičeskaâ revmatologiâ

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During the first months after initiation of urate-lowering therapy in patients with gout, the risk of exacerbating arthritis substantially increases, frequently causing them to refuse this treatment. The main way to avoid this risk is the preventive administration of colchicine, nonsteroidal anti-inflammatory drugs, or glucocorticoids. This prevention of arthritis attacks is stipulated in the latest versions of many national and international guidelines; nevertheless, this tactic is rarely used in practice. The review presents the most significant studies on this problem.

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Oral prednisolone versus non-steroidal anti-inflammatory drugs in the treatment of acute gout: a meta-analysis of randomized controlled trials

Abstract: Oral prednisolone may be of similar efficacy and a slightly safer strategy for treatment of active, acute gout compared with NSAIDs. Further clinical studies are still warranted to investigate its long-term efficacy and safety.

Cited by 7 publications

References 26 publications

Risk of epilepsy in rheumatoid arthritis: a meta-analysis of population based studies and bioinformatics analysis

Risk of epilepsy in rheumatoid arthritis: a meta-analysis of population based studies and bioinformatics analysis

Prophylaxis of Acute Arthritis at Initiation of Urate-Lowering Therapy in Gout Patients

Prevention of arthritis attacks in the use of urate-lowering therapy in patients with gout

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