Oral Phosphates in Vitamin-D-Refractory Rickets and Osteomalacia

Frame, Boy

doi:10.1001/archpedi.1963.02080050149005

Arch Pediatr Adolesc Med

1963

DOI: 10.1001/archpedi.1963.02080050149005

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Oral Phosphates in Vitamin-D-Refractory Rickets and Osteomalacia

Boy Frame¹

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Cited by 20 publications

(2 citation statements)

References 6 publications

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“…Early efforts to treat patients with hypophosphatemic rickets and osteomalacia focused on the application of high doses of vitamin D, which carried a risk for vitamin D toxicity. Frame and Smith noted that adult patients with acquired hypophosphatemic osteomalacia could improve using phosphate salts [124]; in children, the rickets could also be refractory to oral phosphate salts [125]. Given the limited response to vitamin D, Stickler et al [126] tried to treat familial hypophosphatemic rickets by increasing the calcium-phosphate product through increasing intake of phosphate and calcium (on alternating days to ensure absorption), without vitamin D. However, this approach also proved unsuccessful, and they concluded that, at least to some degree, gastrointestinal absorption was also impaired.…”

Section: Phosphate Disorders and Fgf23mentioning

confidence: 99%

Rickets, Vitamin D, and Ca/P Metabolism

Miller

¹

,

Imel

²

2022

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Early efforts to treat patients with hypophosphatemic rickets and osteomalacia focused on the application of high doses of vitamin D, which carried a risk for vitamin D toxicity. Frame and Smith noted that adult patients with acquired hypophosphatemic osteomalacia could improve using phosphate salts [124]; in children, the rickets could also be refractory to oral phosphate salts [125]. Given the limited response to vitamin D, Stickler et al [126] tried to treat familial hypophosphatemic rickets by increasing the calcium-phosphate product through increasing intake of phosphate and calcium (on alternating days to ensure absorption), without vitamin D. However, this approach also proved unsuccessful, and they concluded that, at least to some degree, gastrointestinal absorption was also impaired.…”

Section: Phosphate Disorders and Fgf23mentioning

confidence: 99%

Rickets, Vitamin D, and Ca/P Metabolism

Miller

¹

,

Imel

²

2022

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…[4][5][6] Thus, it seemed reasonable to attempt control of the bone process by giving increased oral intakes of both calcium and phosphate without the addition of high doses of vitamin D. The purpose of this study was to assess the effects of these increased intakes.…”

mentioning

confidence: 99%

Familial Hypophosphatemic Vitamin D Resistant Rickets

Stickler¹

1965

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

X-linked hypophosphataemia and autosomal recessive vitamin D dependency: Models for the resolution of vitamin D refractory rickets

Scriver¹,

Glorieux²,

Reade³

et al. 1976

Inborn Errors of Calcium and Bone Metabolism

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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