2020
DOI: 10.3126/jcmc.v10i1.28082
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Oral Pemphigus Vulgaris: A case report

Abstract: Pemphigus vulgaris is an autoimmune blistering disease clinically presenting as vesicles, bullae and erosion on the skin and mucous membrane. Histopathologically, it is characterized by acantholysis and supra basilar split. The underlying mechanism causing intra epithelial split in pemphigus vulgaris is binding of IgG autoantibodies to desmoglin 3 which belongs to a transmembrane glycoprotein adhesion molecule. Here we present a case of 27 years old male patient suffering from pemphigus vulgaris. This Case rep… Show more

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Cited by 3 publications
(2 citation statements)
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“…The bullae tend to be very fragile, break easily and leave behind denuded surfaces of variable sizes which tend to extend peripherally due to breaking of the epithelium from the underneath dermis. In majority cases of pemphigus vulgaris, the oral mucosa is involved prior to the skin (10). In the present case also, patients had come for the complaint of oral ulcerations with severe pain and burning sensation where the mucosal clefts extended from the periphery.…”
Section: Discussionmentioning
confidence: 52%
“…The bullae tend to be very fragile, break easily and leave behind denuded surfaces of variable sizes which tend to extend peripherally due to breaking of the epithelium from the underneath dermis. In majority cases of pemphigus vulgaris, the oral mucosa is involved prior to the skin (10). In the present case also, patients had come for the complaint of oral ulcerations with severe pain and burning sensation where the mucosal clefts extended from the periphery.…”
Section: Discussionmentioning
confidence: 52%
“…0.1-0.5% and tends to be more common in certain ethnic groups, such as Ashkenazi Jews, Japanese and populations of Mediterranean descent. 28 It primarily affects adults with a female predilection, and the age of onset ranges from 50 to 60 years. In addition to the skin, PV can also affect the pharynx and the oral cavity.…”
Section: Vesiculobullous Diseases Overview Pemphigus Vulgarismentioning
confidence: 99%