Oral omega-3 fatty acids promote resolution in chemical peritonitis

Chacon, Alexander; Phillips, Brett E.; Chacon, Miranda A.; Brunke-Reese, Deborah; Kelleher, Shannon L.; Soybel, David I.

doi:10.1016/j.jss.2016.06.036

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…In murine models of acute inflammation, such as peritonitis, periodontitis, and sepsis, various studies have demonstrated that oral administration of SPMs is effective (Spite, Norling et al 2009, Recchiuti, Codagnone et al 2014, Hasturk, Abdallah et al 2015, Chacon, Phillips et al 2016). The effect of omega-3 fatty acids in acute illness in humans has been studied frequently in the context of the intensive care unit.…”

Section: Translation: Resolution Pharmacology In Vascular Injurymentioning

confidence: 99%

Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications

Mottola

Schaller

et al. 2017

Molecular Aspects of Medicine

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Acute vascular injury occurs in a number of important clinical contexts, including spontaneous disease-related events (e.g. plaque rupture, thrombosis) and therapeutic interventions such as angioplasty, stenting, or bypass surgery. Endothelial cell (EC) disruption exposes the underlying matrix, leading to a rapid deposition of platelets, coagulation proteins, and leukocytes. A thrombo-inflammatory response ensues characterized by leukocyte recruitment, vascular smooth muscle cell (VSMC) activation, and the elaboration of cytokines, reactive oxygen species and growth factors within the vessel wall. A resolution phase of vascular injury may be described in which leukocyte efflux, clearance of debris, and re-endothelialization occurs. VSMC migration and proliferation leads to the development of a thickened neointima that may lead to lumen compromise. Subsequent remodeling involves matrix protein deposition, and return of EC and VSMC to quiescence. Recent studies suggest that specialized proresolving lipid mediators (SPM) modulate key aspects of this response, and may constitute an endogenous homeostatic pathway in the vasculature. SPM exert direct effects on vascular cells that counteract inflammatory signals, reduce leukocyte adhesion, and inhibit VSMC migration and proliferation. These effects appear to be largely G-protein coupled receptor-dependent. Across a range of animal models of vascular injury, including balloon angioplasty, bypass grafting, and experimental aneurysm formation, SPM accelerate repair and reduce lesion formation. With bioactivity in the pM-nM range, a lack of discernible cytotoxicity, and a spectrum of vasculo-protective properties, SPM represent a novel class of vascular therapeutics. This review summarizes current research in this field, including a consideration of critical next steps and challenges in translation.

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Section: Translation: Resolution Pharmacology In Vascular Injurymentioning

confidence: 99%

Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications

Mottola

Schaller

et al. 2017

Molecular Aspects of Medicine

View full text Add to dashboard Cite

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Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice

Wang

Chen

Zhang

et al. 2020

Reproductive Toxicology

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An SPM-Enriched Marine Oil Supplement Shifted Microglia Polarization toward M2, Ameliorating Retinal Degeneration in rd10 Mice

et al. 2022

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Retinitis pigmentosa (RP) is the most common inherited retinal dystrophy causing progressive vision loss. It is accompanied by chronic and sustained inflammation, including M1 microglia activation. This study evaluated the effect of an essential fatty acid (EFA) supplement containing specialized pro-resolving mediators (SPMs), on retinal degeneration and microglia activation in rd10 mice, a model of RP, as well as on LPS-stimulated BV2 cells. The EFA supplement was orally administered to mice from postnatal day (P)9 to P18. At P18, the electrical activity of the retina was examined by electroretinography (ERG) and innate behavior in response to light were measured. Retinal degeneration was studied via histology including the TUNEL assay and microglia immunolabeling. Microglia polarization (M1/M2) was assessed by flow cytometry, qPCR, ELISA and histology. Redox status was analyzed by measuring antioxidant enzymes and markers of oxidative damage. Interestingly, the EFA supplement ameliorated retinal dysfunction and degeneration by improving ERG recording and sensitivity to light, and reducing photoreceptor cell loss. The EFA supplement reduced inflammation and microglia activation attenuating M1 markers as well as inducing a shift to the M2 phenotype in rd10 mouse retinas and LPS-stimulated BV2 cells. It also reduced oxidative stress markers of lipid peroxidation and carbonylation. These findings could open up new therapeutic opportunities based on resolving inflammation with oral supplementation with SPMs such as the EFA supplement.

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Oral omega-3 fatty acids promote resolution in chemical peritonitis

Cited by 3 publications

References 55 publications

Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications

Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications

Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice

An SPM-Enriched Marine Oil Supplement Shifted Microglia Polarization toward M2, Ameliorating Retinal Degeneration in rd10 Mice

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