Oral Nutritional Supplementation Affects the Dietary Intake and Body Weight of Head and Neck Cancer Patients during (Chemo) Radiotherapy

Ferreira, Isabela Borges; Lima, Emanuelle do Nascimento Santos; Canto, Paula Philbert Lajolo; Gontijo, Cristiana Araújo; Maia, Yara Cristina de Paiva; Pena, Geórgia das Graças

doi:10.3390/nu12092516

Cited by 10 publications

(9 citation statements)

References 45 publications

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“…Adequate protein intake minimizes the severity of oral mucositis in patients with head and neck cancer undergoing radiotherapy ( 75 ). Early nutritional intervention, including oral feeding, nasogastric tube, gastrostomy, etc., can significantly improve weight loss and interrupt or delay of radiotherapy ( 76 ).…”

Section: Measures That Can Be Takenmentioning

confidence: 99%

Effect of radiotherapy interruption on nasopharyngeal cancer

Zhao

Yang

2023

Front. Oncol.

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Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial cells of the nasopharynx with a unique geographic distribution, and is particularly prevalent in East and Southeast Asia. Due to its anatomical location, the surgery is difficult to access and the high sensitivity of nasopharyngeal cancer to radiotherapy (RT) makes it the main treatment modality. Radical radiotherapy is the first-line treatment for early-stage nasopharyngeal carcinoma and the cornerstone of multidisciplinary treatment for patients with locally advanced nasopharyngeal carcinoma. Nevertheless, radiotherapy interruption is inevitable as a consequence of unavoidable factors such as public holidays, machine malfunction, patient compliance, and adverse response to treatment, which in turn leads to a reduction in bioactivity and causes sublethal loss of tumor cells to repair. Unirradiated tumor cells are more likely to repopulate at or near their original fastest growth rate during this interval. If no measures are taken after the radiotherapy interruption, such as increasing the dose of radiotherapy and systemic therapy, the tumor is most likely to go uncontrolled and then progress. This review describes the effects of radiotherapy interruption on nasopharyngeal carcinoma, the mechanism of the effect, and explores the measures that can be taken in response to such interruption.

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Section: Measures That Can Be Takenmentioning

confidence: 99%

Effect of radiotherapy interruption on nasopharyngeal cancer

Zhao

Yang

2023

Front. Oncol.

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“…• Due to cancer therapy side effects and inadequate dietary intake by many patients, the American Institute for Cancer Research (AICR), American Cancer Society (ACS) (19) and the European Society for Clinical Nutrition and Metabolism-(ESPEN) (13) support the use of a multivitamin-multimineral supplement in doses close to the recommended dietary allowance. High doses of vitamins and minerals are discouraged in the absence of specific deficiencies (13) • Compared to no counselling, individualized dietary counselling showed significant benefits on nutritional status and QOL (p < 0.05) (44) • A prospective observational study with HNC patient during chemo-radiotherapy recommend initiating nutritional counselling in conjunction with prophylactic ONS prescription from diagnosis to adjust the nutrient intake and minimize weight loss (45) • ONS has a lower impact in overcoming nutritional deficiencies in cancer patients when provided orally than via enteral nutrition (46) • A meta-analysis of 11 clinical studies indicated that high-protein, omega-3, and PUFA enriched diets have an overall benefit of increasing the bodyweight of patients receiving chemoradiotherapy compared with other types of diets. However, the impact on the reduction of treatment toxicity and survival is limited (47) • Some clinical studies have proven that the use of fish-derived, omega-3 polyunsaturated fatty acids (2 g/day) in individuals with advanced cancer receiving chemotherapy improve appetite, energy intake, body weight, muscle mass, and/or physical activity.…”

Section: Recommendationmentioning

confidence: 99%

IAPEN India : Nutrition Consensus Guidelines in Oncology Clinical Practice

Timmanpyati¹,

Parikh²,

Bajaj³

et al. 2021

JNUTRES

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Malnutrition is one of the most common and significant issue during the treatment of cancer. Poor nutritional management during the treatment may impede the progress in the treatment. Many international societies have nutritional recommendations published on their websites. India, being a multicultural population with varied nutritional habits and local beliefs have no cohesive evidence-based nutritional approach during and after treatment. The current guideline has been formulated jointly by oncologists, nutritionists, and multidisciplinary professionals with an aim to provide science based standard nutritional guidance to the community healthcare professionals across India. The committee referred to major international guidelines published in recent past. With intense deliberations adopted few selective recommendations which are compatible with Indian practice. Keywords: Cancer, Nutrition, Consensus guideline, nutrition in cancer, IAPEN guidelines, IAPEN cancer guidelines

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“…Ferreira et al [ 35 ] investigated the association between treatment time points and oral nutritional supplementation (ONS) on dietary intake to estimate the frequency of energy and nutrient inadequacy and also to evaluate body weight changes (BWC). Dietary intake data of 65 patients were obtained from 24-h dietary recalls, and prevalence of inadequacy was calculated before or at the beginning (T0), in the middle (T1), and at the end of treatment (T2).…”

Section: The Nutritional Counseling and Oral Nutritional Supplemenmentioning

confidence: 99%

“…Patients receiving ONS showed a lower weight loss. Therefore, the authors strongly recommended initiating nutritional counseling from diagnosis to optimize macronutrient intake in conjunction with prophylactic ONS prescription to adjust micronutrient intake and minimize the weight loss, making it possible to prevent worse prognosis and NS [ 35 ].…”

Section: The Nutritional Counseling and Oral Nutritional Supplemenmentioning

confidence: 99%

Nutritional Support in Head and Neck Radiotherapy Patients Considering HPV Status

et al. 2020

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Malnutrition is a common problem in patients with head and neck cancer (HNC), including oropharyngeal cancer (OPC). It is caused by insufficient food intake due to dysphagia, odynophagia, and a lack of appetite caused by the tumor. It is also secondary to the oncological treatment of the basic disease, such as radiotherapy (RT) and chemoradiotherapy (CRT), as a consequence of mucositis with the dry mouth, loss of taste, and dysphagia. The severe dysphagia leads to a definitive total impossibility of eating through the mouth in 20–30% of patients. These patients usually require enteral nutritional support. Feeding tubes are a commonly used nutritional intervention during radiotherapy, most frequently percutaneous gastrostomy tube. Recently, a novel HPV-related type of OPC has been described. Patients with HPV-associated OPC are different from the HPV− ones. Typical HPV− OPC is associated with smoking and alcohol abuse. Patients with HPV+ OPC are younger and healthy (without comorbidities) at diagnosis compared to HPV− ones. Patients with OPC are at high nutritional risk, and therefore, they require nutritional support in order to improve the treatment results and quality of life. Some authors noted the high incidence of critical weight loss (CWL) in patients with HPV-related OPC. Other authors have observed the increased acute toxicities during oncological treatment in HPV+ OPC patients compared to HPV− ones. The aim of this paper is to review and discuss the indications for nutritional support and the kinds of nutrition, including immunonutrition (IN), in HNC, particularly OPC patients, undergoing RT/CRT, considering HPV status.

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Oral Nutritional Supplementation Affects the Dietary Intake and Body Weight of Head and Neck Cancer Patients during (Chemo) Radiotherapy

Cited by 10 publications

References 45 publications

Effect of radiotherapy interruption on nasopharyngeal cancer

Effect of radiotherapy interruption on nasopharyngeal cancer

IAPEN India : Nutrition Consensus Guidelines in Oncology Clinical Practice

Nutritional Support in Head and Neck Radiotherapy Patients Considering HPV Status

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