Oral Nicotine Self-Administration in Rodents

Collins, Allan C.; Pöğün, Şakire; Nesil, Tanseli; Kanıt, Lütfiye

doi:10.4172/2155-6105.s2-004

Cited by 17 publications

(14 citation statements)

References 114 publications

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“…Compared to the intravenous self-administration paradigm, this approach allowed us to overcome the challenges associated with the small size of young mice and the need for prolonged catheter patency. Despite resulting in slower pharmacokinetics compared to intravenous nicotine selfadministration, the 2BC model produces an expected inverted U-shape dose-response curve for nicotine and leads to symptoms of withdrawal when nicotine is withheld (Bagdas et al, 2019;Pogun and C Collins, 2012).…”

Section: Discussionmentioning

confidence: 99%

Exposure to fruit-flavoring during adolescence increases nicotine consumption and promotes dose escalation

Patten

Dreier

Herman

et al. 2021

Preprint

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The rise of e-cigarette popularity has sparked interest in the role of palatable flavors on nicotine use. Despite growing evidence that sweet flavorants enhance nicotine reward, their influence on nicotine consumption has not been studied extensively. In addition, the impact that flavored nicotine use in adolescence could have on nicotine reward and dependence in adulthood remains unclear. This study examined the role of flavored nicotine access on nicotine preference and consumption longitudinally, from adolescence to adulthood. Male and female adolescent mice preferred a fruit-flavored nicotine solution. However, only adolescent female mice with access to flavored nicotine consumed higher doses. Furthermore, while adolescent male mice escalated consumption of both flavored and unflavored nicotine, female mice only escalated when given access to flavored nicotine. As mice matured into adulthood, there was no evidence that a history of flavored-nicotine access altered preference for unflavored nicotine. However, when the nicotine concentration was reduced, mice that had consumed strawberry-flavored nicotine in adolescence maintained baseline nicotine consumption levels longer than mice that initiated nicotine use without flavor in adolescence. Finally, addition of fruit-flavorants into the nicotine solution during adulthood led to increased levels of nicotine consumption, regardless of previous flavored-nicotine access or of familiarity with the selected flavorant. These results indicate that flavorants increase nicotine consumption independent of life stage, possibly posing a disproportionate risk to adolescent females. Our results also point to an effect of adolescent flavored-nicotine use on nicotine dose maintenance in adulthood, which could have implications for the success of future quit attempts.

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Section: Discussionmentioning

confidence: 99%

Exposure to fruit-flavoring during adolescence increases nicotine consumption and promotes dose escalation

Patten

Dreier

Herman

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Therefore, alternating the position of liquids in the two sipper tubes across time may be needed to control for this bias in preference assays. Second, the device currently requires animals to be singly housed, which may limit how many experiments can be run simultaneously due to space constraints and could introduce stress that may affect behavioral assays (Collins et al, 2012; Kamakura et al, 2016). However, as the device is open source, it could be modified to include additional sensors for discriminating multiple animals, such as RFID (radio-frequency identification) sensors that have been used in some commercial systems for this purpose (Galsworthy et al, 2005; Bains et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

An Open-Source, Automated Home-Cage Sipper Device for Monitoring Liquid Ingestive Behavior in Rodents

Godynyuk

Bluitt

Tooley

et al. 2019

eNeuro

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“…Interestingly, Cre(+) mice showed greater nicotine intake (significant at the highest concentration offered) but did not demonstrate nicotine CPP at the selected nicotine dose of 0.25 mg/kg. The assays differ with respect to controllability of drug exposure, route of drug administration, kinetics of nicotine exposure, number of nicotine exposures, and variability of nicotine dosage [ 45 ]. Oral self-administration assays are frequently used to assess the motivational effects of abused drugs and have the advantage of allowing the animal to control their own intake of the drug, thereby providing a relatively direct index of its reinforcing value.…”

Section: Discussionmentioning

confidence: 99%

Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain

Peng¹,

Engle²,

Yan³

et al. 2017

PLoS ONE

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Nicotinic acetylcholine receptors containing α4 subunits (α4β2* nAChRs) are critical for nicotinic cholinergic transmission and the addictive action of nicotine. To identify specific activities of these receptors in the adult mouse brain, we coupled targeted deletion of α4 nAChR subunits with behavioral and and electrophysiological measures of nicotine sensitivity. A viral-mediated Cre/lox approach allowed us to delete α4 from ventral midbrain (vMB) neurons. We used two behavioral assays commonly used to assess the motivational effects of drugs of abuse: home-cage oral self-administration, and place conditioning. Mice lacking α4 subunits in vMB consumed significantly more nicotine at the highest offered nicotine concentration (200 μg/mL) compared to control mice. Deletion of α4 subunits in vMB blocked nicotine-induced conditioned place preference (CPP) without affecting locomotor activity. Acetylcholine-evoked currents as well as nicotine-mediated increases in synaptic potentiation were reduced in mice lacking α4 in vMB. Immunostaining verified that α4 subunits were deleted from both dopamine and non-dopamine neurons in the ventral tegmental area (VTA). These results reveal that attenuation of α4* nAChR function in reward-related brain circuitry of adult animals may increase nicotine intake by enhancing the rewarding effects and/or reducing the aversive effects of nicotine.

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Oral Nicotine Self-Administration in Rodents

Cited by 17 publications

References 114 publications

Exposure to fruit-flavoring during adolescence increases nicotine consumption and promotes dose escalation

Exposure to fruit-flavoring during adolescence increases nicotine consumption and promotes dose escalation

An Open-Source, Automated Home-Cage Sipper Device for Monitoring Liquid Ingestive Behavior in Rodents

Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain

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