Oral nanoparticles based on gellan gum/pectin for colon-targeted delivery of resveratrol

Prezotti, Fabíola Garavello; Boni, Fernanda Isadora; Ferreira, Natália Noronha; Silva, Daniella Souza; Almeida, Andreia; Vasconcelos, Teófilo; Sarmento, Bruno; Gremião, Maria Palmira Daflon; Cury, Beatriz Stringhetti Ferreira

doi:10.1080/03639045.2020.1716374

Cited by 49 publications

(10 citation statements)

References 57 publications

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“…Therefore, various therapeutic substances have already been successfully incorporated into bacterial-based polysaccharide nanoparticles. For example, gellan gum and levan nanoparticles have been successfully loaded with resveratrol for oral administration [ 268 , 269 ], and the hydrophilic antihypertensive drug Atenol was incorporated into gellan gum nanoparticles [ 270 ]. Moreover, a chemotherapy drug, doxorubicin, was also successfully incorporated into xanthan gum nanoparticles [ 271 ].…”

Section: Bacterial-based Biopolymeric Nanoparticles Used For Healthca...mentioning

confidence: 99%

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Kučuk

Primožič

Knez

et al. 2023

IJMS

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Biopolymeric nanoparticles are gaining importance as nanocarriers for various biomedical applications, enabling long-term and controlled release at the target site. Since they are promising delivery systems for various therapeutic agents and offer advantageous properties such as biodegradability, biocompatibility, non-toxicity, and stability compared to various toxic metal nanoparticles, we decided to provide an overview on this topic. Therefore, the review focuses on the use of biopolymeric nanoparticles of animal, plant, algal, fungal, and bacterial origin as a sustainable material for potential use as drug delivery systems. A particular focus is on the encapsulation of many different therapeutic agents categorized as bioactive compounds, drugs, antibiotics, and other antimicrobial agents, extracts, and essential oils into protein- and polysaccharide-based nanocarriers. These show promising benefits for human health, especially for successful antimicrobial and anticancer activity. The review article, divided into protein-based and polysaccharide-based biopolymeric nanoparticles and further according to the origin of the biopolymer, enables the reader to select the appropriate biopolymeric nanoparticles more easily for the incorporation of the desired component. The latest research results from the last five years in the field of the successful production of biopolymeric nanoparticles loaded with various therapeutic agents for healthcare applications are included in this review.

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Section: Bacterial-based Biopolymeric Nanoparticles Used For Healthca...mentioning

confidence: 99%

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Kučuk

Primožič

Knez

et al. 2023

IJMS

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“…A study also showed that resveratrol had low permeability and high retention in the intestinal tissue of mice. This is advantageous for effective CTDD due to the accumulation of the drug in the colon, thereby increasing local action, and interfering with systemic absorption (Prezotti et al, 2020).…”

Section: Resveratrolmentioning

confidence: 99%

Delivery of Potential Drugs to The Colon: Challenges and Strategies

Iswandana

Putri²,

Larasati³

et al. 2022

Indonesian J Pharm

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Colon-targeted drug delivery systems have been exploited to treat local diseases in the colon, systemic delivery of protein and peptide, and chronotherapeutic drugs. The upper gastrointestinal tract restricts the effective delivery of these drugs. Therefore, several strategies are needed for targeted drugs directly to the colon, such as pH-sensitive polymers, enzyme-sensitive polymers, bacterially degradable polysaccharides, time-dependent polymers, and particulate systems. However, variable physiological conditions of the gastrointestinal tract in individuals cause combinations of these strategies are needed to ensure colonic delivery of the drug. This review presents and discusses several potential drugs and their approaches used to design and develop colon-targeted drug delivery systems for medications with particular characteristics.

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“…Microencapsulation can be considered a powerful technological strategy for designing innovative delivery systems for oral drug administration. This strategy allows the modulation of critical physical-chemical and/or biological properties of drug molecules, which can enhance systemic or local action depending on the formulations and technological approaches used [2][3][4][5][6]. In addition to carrying active compounds, such as drugs, nano-systems can also be microencapsulated, which may, in turn, help to effectively control drug release rates and provide protection against in vivo degradation [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Ionic Cross-Linking as a Strategy to Modulate the Properties of Oral Mucoadhesive Microparticles Based on Polysaccharide Blends

et al. 2021

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Polymer blends of gellan gum (GG)/retrograded starch(RS) and GG/pectin (P) were cross-linked with calcium, aluminum, or both to prepare mucoadhesive microparticles as oral carriers of drugs or nano systems. Cross-linking with different cations promoted different effects on each blend, which can potentially be explored as novel strategies for modulating physical–chemical and mucoadhesive properties of microparticles. Particles exhibited spherical shapes, diameters from 888 to 1764 µm, and span index values lower than 0.5. Blends of GG:P cross-linked with aluminum resulted in smaller particles than those obtained by calcium cross-linking. GG:RS particles exhibited larger sizes, but cross-linking this blend with calcium promoted diameter reduction. The uptake rates of acid medium were lower than phosphate buffer (pH 6.8), especially GG:RS based particles cross-linked with calcium. On the other hand, particles based on GG:P cross-linked with calcium absorbed the highest volume of acid medium. The percentage of systems erosion was higher in acid medium, but apparently occurred in the outermost layer of the particle. In pH 6.8, erosion was lower, but caused expressive swelling of the matrixes. Calcium cross-linking of GG:RS promoted a significantly reduction on enzymatic degradation at both pH 1.2 and 6.8, which is a promising feature that can provide drug protection against premature degradation in the stomach. In contrast, GG:P microparticles cross-linked with calcium suffered high degradation at both pH values, an advantageous feature for quickly releasing drugs at different sites of the gastrointestinal tract. The high mucoadhesive ability of the microparticles was evidenced at both pH values, and the Freundlich parameters indicated stronger particle–mucin interactions at pH 6.8.

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Oral nanoparticles based on gellan gum/pectin for colon-targeted delivery of resveratrol

Cited by 49 publications

References 57 publications

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Delivery of Potential Drugs to The Colon: Challenges and Strategies

Ionic Cross-Linking as a Strategy to Modulate the Properties of Oral Mucoadhesive Microparticles Based on Polysaccharide Blends

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