Oral N-acetylcysteine as an adjunct to standard medical therapy improved heart function in cases with stable class II and III systolic heart failure

Yazdi, Amirhossein; Khansari, Nakisa; Mehrpooya, Maryam; Mohammadi, Younes; Zareie, Shiva

doi:10.1007/s11845-021-02829-3

Cited by 1 publication

(1 citation statement)

References 79 publications

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“…In accordance, Chen et al [ 66 ] presented attenuated TAPSE and RV dilation going along with reduced RV hypertrophy and fibrosis in MCT rats [ 66 ]. Of note, Yazdi et al [ 77 ] showed significantly improved RV systolic function in parallel with benefits in LV systolic function in HF patients with reduced ejection fraction (HFrEF) after 12 weeks of oral NAC treatment compared to the placebo [ 77 ]. The effects of H 2 S donors such as NaHS were analyzed in experimental models after myocardial infarction, showing improved mitochondrial integrity and decreased cardiac apoptosis [ 91 ].…”

Section: Therapeutic Options To Reduce Mitochondrial Oxidative Stress...mentioning

confidence: 99%

Mitochondrial Integrity Is Critical in Right Heart Failure Development

Müller,

Donhauser,

Maske

et al. 2023

IJMS

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Molecular processes underlying right ventricular (RV) dysfunction (RVD) and right heart failure (RHF) need to be understood to develop tailored therapies for the abatement of mortality of a growing patient population. Today, the armament to combat RHF is poor, despite the advancing identification of pathomechanistic processes. Mitochondrial dysfunction implying diminished energy yield, the enhanced release of reactive oxygen species, and inefficient substrate metabolism emerges as a potentially significant cardiomyocyte subcellular protagonist in RHF development. Dependent on the course of the disease, mitochondrial biogenesis, substrate utilization, redox balance, and oxidative phosphorylation are affected. The objective of this review is to comprehensively analyze the current knowledge on mitochondrial dysregulation in preclinical and clinical RVD and RHF and to decipher the relationship between mitochondrial processes and the functional aspects of the right ventricle (RV).

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