Oral myoepithelioma of soft tissue origin: report of a new case and literature review

Nikitakis, Nikolaos G.; Argyris, Prokopios P.; Sklavounou, Alexandra; Papadimitriou, John C.

doi:10.1016/j.tripleo.2010.05.074

Cited by 17 publications

(28 citation statements)

References 14 publications

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“…Considering the clinicopathological features of the current cases and those 42 cases reported as ECT, a designation of this lingual neoplasm as myoepithelioma may create confusion and it should be avoided as ECT is by now well accepted and established as an entity 19 . Therefore, the two previously reported cases of myoepithelioma affecting the tongue, exhibiting similar histopathological and immunohistochemical characteristics with ECT, should be considered as ECT of the tongue 8,18 …”

Section: Discussionmentioning

confidence: 97%

“…19 Therefore, the two previously reported cases of myoepithelioma affecting the tongue, exhibiting similar histopathological and immunohistochemical characteristics with ECT, should be considered as ECT of the tongue. 8,18 In conclusion, ECT is a rare asymptomatic benign mesenchymal neoplasm located on the anterior dorsum of the tongue of adults. Microscopically it is characterized by ovoid and fusiform cells and variable amounts of cellular, myxoid and chondroid background.…”

Section: Discussionmentioning

confidence: 98%

“…Some tumors may present occasional foci of cellular atypia and nuclear pseudoinclusions 1,12,13 . Tumor cells of ECT are diffusely immunoreactive for vimentin, glial fibrillary acidic protein (GFAP), S‐100 protein and neuron‐specific enolase (NSE), 5,9–13 while cytokeratins (CK), CD57 and α‐smooth muscle actin (α‐SMA) can also be positive in 45–70% of the cases 16–20 …”

Section: Clinical Features Of 42 Cases Of Ectomesenchymal Chondromyxomentioning

confidence: 99%

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Ectomesenchymal chondromyxoid tumor: histopathologic and immunohistochemical study of two cases without a chondroid component

et al. 2012

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Ectomesenchymal chondromyxoid tumor (ECT) is a rare benign neoplasm usually affecting the anterior dorsum of the tongue. Histopathologically, it is formed by spindle, round and/or polygonal cells embedded in a chondromyxoid matrix. Immunohistochemical positivity for vimentin, S‐100 protein, glial fibrillary acid protein and neuron‐specific enolase are helpful to confirm the diagnosis. There are 42 cases of ECT of the tongue reported in the English language literature, three of them showing no chondroid matrix. We describe two additional cases of ECT lacking the chondroid component, exhibiting areas of reticulated myxoid and cellular pattern. Considering the microscopical features, ECT can be classified in classic and ‘chondroid‐free’ variants, the latter including the reticulated myxoid and cellular patterns. It is important to consider that the cellular ECT usually exhibits predominance of an infiltrative atypical cellular component that may mimic a malignant tumor. Palma Guzmán JM, de Andrade BAB, Rizo VHT, Romañach MJ, León JE, de Almeida OP. Ectomesenchymal chondromyxoid tumor: histopathologic and immunohistochemical study of two cases without a chondroid component.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Section: Clinical Features Of 42 Cases Of Ectomesenchymal Chondromyxomentioning

confidence: 99%

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Ectomesenchymal chondromyxoid tumor: histopathologic and immunohistochemical study of two cases without a chondroid component

et al. 2012

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“…Most lesions occur in the limbs, followed by head and neck and trunk. [196][197][198][199][200][201] They originate in subcutis or deep soft tissue (including retroperitoneum 202 ), and form lobulated, grossly circumscribed but microscopically infiltrative tumours composed of spindled ( Figure 1N), epithelioid, plasmacytoid or clear cells arranged in files, cords or small nests. Mixed tumours have apocrine or eccrine duct formation.…”

Section: Y O E P I T H E L I a L T U M O U R S O F S O F T T I S S U Ementioning

confidence: 99%

The diversity of soft tissue tumours with EWSR1 gene rearrangements: a review

2013

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Many soft tissue sarcomas have chromosomal translocations with resultant formation of new fusion genes. Among the genes that can be rearranged, the EWSR1 gene has been identified as a partner in a wide variety of clinically and pathologically diverse sarcomas as well as some non-mesenchymal tumours. The former include Ewing sarcoma and similar (Ewing-like) small round cell sarcomas, desmoplastic small round cell tumour, myxoid liposarcoma, extraskeletal myxoid chondrosarcoma, angiomatoid fibrous histiocytoma, clear cell sarcoma of soft tissue and clear cell sarcoma-like tumours of the gastrointestinal tract, primary pulmonary myxoid sarcoma, extrasalivary myoepithelial tumours and sporadic examples of low-grade fibromyxoid sarcoma, sclerosing epithelioid fibrosarcoma and mesothelioma. EWSR1 is a 'promiscuous' gene that can fuse with many different partner genes, but sometimes this results in phenotypically identical tumours. EWSR1 can, conversely, partner with the same genes in morphologically and behaviourally different neoplasms. This paper reviews the diversity of the several soft tissue tumour types that are associated with rearrangement of the EWSR1 gene.

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“…The typical anatomic locations include subcutis and deep soft tissue [2]. Clinical presentation is of a localized asymptomatic nodule or mass growing for prolonged periods of time [4]. Phenotypic plasticity of myoepithelial cells and their capacity of both epithelial and muscular differentiation result in significant morphologic variability of MSTs [3].…”

Section: Quiz Correct Answer To the Quiz Check Your Diagnosismentioning

confidence: 99%

ANSWER TO THE QUIZ Subcutaneous myoepithelioma of soft tissue: a

Jedrych¹,

Vu²

2013

pjp

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We present a case of a 75-year-old female with a subcutaneous back mass diagnosed as myoepithelioma of soft tissue. The diagnosis of this tumor may be challenging and familiarity with its broad morphological spectrum is important to distinguish it from a number of histologically similar soft tissue proliferations, in particular those displaying a prominent myxoid stroma. The correct diagnosis can be facilitated by the use of a panel of confirmatory immunohistochemical markers, including cytokeratins, neural, and muscular antigens, revealing the myoepithelial nature of the tumor cells.

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Oral myoepithelioma of soft tissue origin: report of a new case and literature review

Cited by 17 publications

References 14 publications

Ectomesenchymal chondromyxoid tumor: histopathologic and immunohistochemical study of two cases without a chondroid component

Ectomesenchymal chondromyxoid tumor: histopathologic and immunohistochemical study of two cases without a chondroid component

The diversity of soft tissue tumours with EWSR1 gene rearrangements: a review

ANSWER TO THE QUIZ Subcutaneous myoepithelioma of soft tissue: a

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