Oral myeloid sarcoma: two case reports

Abstract

Myeloid sarcoma, also commonly termed granulocytic sarcoma or chloroma, is a rare condition involving infiltration of immature myeloid cells in an extramedullary site. Myeloid sarcoma is often related to leukaemia; however, the condition can also occur in association with various myeloproliferative disorders. Although myeloid sarcoma can occur in any body part, involvement of the neoplastic condition in the oral cavity is infrequent with only 37 cases reported in the literature. We will describe two cases of oral myeloid sarcoma observed at The Alfred Hospital's Dental Unit and discuss their presenting features, diagnosis and subsequent management.

Myeloid sarcoma in the tongue

“…Although the infiltration of malignant cells into the oral tissues is not an uncommon feature in leukemic patients, especially in patients with acute leukemia, infiltration of the tongue is rare 19 . On the other hand, while myeloid sarcomas can occur in any part of the body, the involvement of the oral cavity is uncommon, with only 37 cases reported according to the Yap et al 20 report.…”

Sarcoma mieloide intraoral: forma poco común de debut de la leucemia aguda mieloide

“…También son frecuentes las úlceras orales y las infecciones intraorales por hongos, bacterias o virus (gingivoestomatitis herpética) debido a la inmunosupresión 2 . El SM es una forma muy rara de manifestación de la leucemia a nivel intraoral, habiéndose reportado muy pocos casos hasta la fecha 5 .…”

Intraoral Myeloid sarcoma with bilateral involvement: Case report

“…Myeloid sarcoma (MS) is a solid malignant tumour associated with infiltration of immature myeloid precursor cells in an extramedullary site 1 . The term MS has replaced the term granulocytic sarcoma and chloroma, which were used in the past 2 .…”

“…MS in the oral cavity is very uncommon with less of 40 cases reported between 1883 and 2014 1 . MS can occur during the course of acute or chronic myeloid leukaemia, and myelodysplastic syndromes.…”