Oral mycobiome in community‐dwelling elderly and its relation to oral and general health conditions

Zakaria, Myrna Nurlatifah; Furuta, Michiko; Takeshita, Toru; Shibata, Yukie; Sundari, Rini; Eshima, Nobuoki; Ninomiya, Toshiharu; Yamashita, Yoshihisa

doi:10.1111/odi.12682

Cited by 35 publications

(42 citation statements)

References 43 publications

(70 reference statements)

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“…In another recent study, Zakaria et al. () noted that the oral cavities of those with lower BMI (body mass index) were more frequently colonized with Candida dubliniensis and Candida glabrata while those with lower salivary flow rates were colonized by C. albicans . Nonetheless, new studies using novel, culture‐independent analyses, such as NGS technology, are needed to re‐evaluate the fungal diversity in human mouth under changing physiological and chronological conditions as historical data are likely to be biased towards the yeasts that flourished in conventional laboratory culture.…”

Section: Oral Mycobiome and Oral Physiologymentioning

confidence: 98%

“…In comparison with the elderly, the carriage of Candida in the oral cavities of infants at birth is lower and colonization rates rise with age reaching adult carriage rates in the first year of life (Kleinegger, Lockhart, Vargas, & Soll, 1996;Russell & Lay, 1973;Ward, Knights, & Gale, 2017). In another recent study, Zakaria et al (2017) noted that the oral cavities of those with lower BMI (body mass index) were more frequently colonized with Candida dubliniensis and Candida glabrata while those with lower salivary flow rates were colonized by C. albicans. Nonetheless, new studies using novel, culture-independent analyses, such as NGS technology, are needed to re-evaluate the fungal diversity in human mouth under changing physiological and chronological conditions as historical data are likely to be biased towards the yeasts that flourished in conventional laboratory culture.…”

Section: Or Al Mycob Iome and Or Al Phys Iologymentioning

confidence: 99%

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Biodiversity of the human oral mycobiome in health and disease

2018

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The organisms that colonize the human body over a lifetime are diverse, extensive and gargantuan. A fair proportion of the microbiota that constitutes this human microbiome live within our oral cavities mostly as harmonious associates causing only sporadic disease. An important core constituent of the microbiome is the mycobiome, representing various fungal genera. Up until recently, only a few species of fungi, mainly Candida species, were thought to constitute the human oral mycobiome. The reasons for this are manifold, although the uncultivable nature of many fungi in conventional laboratory media, and their complex genetic composition seem to be the major factors which eluded their detection over the years. Nevertheless, recent advances in computing and high-throughput sequencing such as next-generation sequencing (NGS) platforms have provided us a panoramic view of a totally new world of fungi that are human oral cohabitués. Their diversity is perplexing, and functionality yet to be deciphered. Here, we provide a glimpse of what is currently known of the oral mycobiome, in health and disease, with some future perspectives.

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Section: Oral Mycobiome and Oral Physiologymentioning

confidence: 98%

Section: Or Al Mycob Iome and Or Al Phys Iologymentioning

confidence: 99%

Biodiversity of the human oral mycobiome in health and disease

2018

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“…The high prevalence of Candida in the oral cavity is consistent with previous culture-based studies, and subsequent molecular studies confirmed the high prevalence of Candida spp. within the oral cavity, reporting Candida albicans , Candida parapsilosis and Candida dubliniensis as the most abundant oral Candida species [ 26 , 29 , 30 ].…”

Section: The Mycobiomementioning

confidence: 99%

The Human Mucosal Mycobiome and Fungal Community Interactions

Witherden

Shoaie

Hall

et al. 2017

JoF

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With the advent of high-throughput sequencing techniques, the astonishing extent and complexity of the microbial communities that reside within and upon us has begun to become clear. Moreover, with advances in computing and modelling methods, we are now beginning to grasp just how dynamic our interactions with these communities are. The diversity of both these communities and their interactions—both within the community and with us—are dependent on a multitude of factors, both microbial- and host-mediated. Importantly, it is becoming clear that shifts in the makeup of these communities, or their responses, are linked to different disease states. Although much of the work to define these interactions and links has been investigating bacterial communities, recently there has been significant growth in the body of knowledge, indicating that shifts in the host fungal communities (mycobiome) are also intimately linked to disease status. In this review, we will explore these associations, along with the interactions between fungal communities and their human and microbial habitat, and discuss the future applications of systems biology in determining their role in disease status.

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“…Over the last ten years, some studies have found an increase in the Non-Albicans Candida (NAC) recovery frequency in oral mucosa: from 10 % in 1996 [15] to 15.0% [16] in 2010, 15.4 % in 2011 [17], and 20.0% in 2017 [35] in the case of C. parapsilosis at the level of healthy subjects. Among the local and/or systemic factors associated with the higher distribution of NAC species in the oral cavity, we could mention the use of prosthetic devices; [64] being elderly [65], elderly with low body mass index [66]; being an oncological patient undergoing chemotherapy or radiotherapy…”

Section: Oral Mucosa As a Potential Source Of Candidemia By Candida Pmentioning

confidence: 99%

Oral mucosa as a potential source of candidemia by Candida parapsilosis sensu stricto, under pathological conditions

Ml¹,

Ac²,

Jg³

et al. 2018

SOJMID

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Over the past 10 years, there have been increasingly frequent reports of colonization of niches in the oral cavity by Non-Candida Albicans Candida (NCAC) species. Among these species, Candida parapsilosis sensu stricto plays a major part both locally and systemically. Evidence shows that it may be the second most frequent yeast isolate, after Candida albicans, as commensal in the oral cavity and as pathogen in blood cultures of patients diagnosed with fungemia. Recent reports suggest that both its distribution and its virulence may be affected by environmental conditions and may increase in situations of oral dysbiosis. Based on this background, we hypothesize that oral mucosa in pathological condition may be a source of candidemia by Candida parapsilosis sensu stricto, when promoted by the conditions in the host. We reviewed the scientific databases in search of evidence which may support such hypothesis.

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Oral mycobiome in community‐dwelling elderly and its relation to oral and general health conditions

Abstract: Candida albicans, C. glabrata, and C. dubliniensis dominated the oral mycobiome in Japanese community-dwelling elderly. Lower BMI might signify compromised health status and thus could result in susceptibility to specific candidiasis by C. glabrata and C. dubliniensis.

Cited by 35 publications

References 43 publications

Biodiversity of the human oral mycobiome in health and disease

Biodiversity of the human oral mycobiome in health and disease

The Human Mucosal Mycobiome and Fungal Community Interactions

Oral mucosa as a potential source of candidemia by Candida parapsilosis sensu stricto, under pathological conditions

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