Oral Mucositis: Melatonin Gel an Effective New Treatment

Moneim, Ahmed E. Abdel; Guerra‐Librero, Ana; Florido, Javier; Shen, Yingqiang; Fernández-Gil, Beatriz; Acuña-Castroviejo, Darı́o; Escames, Germaine

doi:10.3390/ijms18051003

Cited by 35 publications

(10 citation statements)

References 145 publications

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“…Locally, MT may also be used in the prevention of the side effects of chemo/radiotherapy, such as oral mucositis and dermatitis. In the case of mucositis, MT is given as an oral gel, applied by rinsing the mouth without swallowing it [ 353 ]. Moreover, an MT gel can be applied in the zone to be irradiated 15 min before each session to avoid the damaging effects of radiation on the skin [ 353 , 354 ].…”

Section: Towards a H + -Related Concerted Utilimentioning

confidence: 99%

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Harguindey¹,

Alfarouk

Orozco³

et al. 2020

IJMS

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A brand new approach to the understanding of breast cancer (BC) is urgently needed. In this contribution, the etiology, pathogenesis, and treatment of this disease is approached from the new pH-centric anticancer paradigm. Only this unitarian perspective, based upon the hydrogen ion (H+) dynamics of cancer, allows for the understanding and integration of the many dualisms, confusions, and paradoxes of the disease. The new H+-related, wide-ranging model can embrace, from a unique perspective, the many aspects of the disease and, at the same time, therapeutically interfere with most, if not all, of the hallmarks of cancer known to date. The pH-related armamentarium available for the treatment of BC reviewed here may be beneficial for all types and stages of the disease. In this vein, we have attempted a megasynthesis of traditional and new knowledge in the different areas of breast cancer research and treatment based upon the wide-ranging approach afforded by the hydrogen ion dynamics of cancer. The concerted utilization of the pH-related drugs that are available nowadays for the treatment of breast cancer is advanced.

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Section: Towards a H + -Related Concerted Utilimentioning

confidence: 99%

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Harguindey¹,

Alfarouk

Orozco³

et al. 2020

IJMS

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“…However, oral inflammation such as stomatitis are considered to be triggered or aggravated by various factors including bacterial and viral infections, nutritional deficiencies, declined immune functions, allergic reactions, radiotherapy, stress, cigarettes, diseases and genetic backgrounds [1,2]. Applications of topical steroids, transdermal patches, vitamins, throat lozenges, mouth washes and cryotherapy are sometimes not effective for the treatment of stomatitis and therefore exploration of new-type of treatment are necessary [3]. In this sense, natural products having broader spectrum of biological activities are potential candidates as alternative medicine for oral diseases.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress of Basic Studies of Natural Products and Their Dental Application

et al. 2018

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The present article reviews the research progress of three major polyphenols (tannins, flavonoids and lignin carbohydrate complexes), chromone (backbone structure of flavonoids) and herbal extracts. Chemical modified chromone derivatives showed highly specific toxicity against human oral squamous cell carcinoma cell lines, with much lower toxicity against human oral keratinocytes, as compared with various anticancer drugs. QSAR analysis suggests the possible correlation between their tumor-specificity and three-dimensional molecular shape. Condensed tannins in the tea extracts inactivated the glucosyltransferase enzymes, involved in the biofilm formation. Lignin-carbohydrate complexes (prepared by alkaline extraction and acid-precipitation) and crude alkaline extract of the leaves of Sasa species (SE, available as an over-the-counter drug) showed much higher anti-HIV activity, than tannins, flavonoids and Japanese traditional medicine (Kampo). Long-term treatment with SE and several Kampo medicines showed an anti-inflammatory and anti-oxidant effects in small size of clinical trials. Although the anti-periodontitis activity of synthetic angiotensin II blockers has been suggested in many papers, natural angiotensin II blockers has not yet been tested for their possible anti-periodontitis activity. There should be still many unknown substances that are useful for treating the oral diseases in the natural kingdom.

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“…This assumption has recently been questioned, since several organs and glands were claimed to produce melatonin (Hevia et al, ; Venegas et al, ; Acuña‐Castroviejo et al, ) and mitochondria are believed to be the preferentially sites of melatonin production in peripheral tissues (Tan D‐X et al, , Reiter et al, ; Suofu et al, ). Moreover, the oral mucosa and the salivary glands themselves have been considered extrapineal sources of this indoleamine, because the enzymes involved in melatonin synthesis were found in both the oral mucosa and the glandular parenchyma (Shimozuma et al, ; Abdel Moneim et al, ). Moreover, besides passive diffusion, new evidence supports the existence of an as yet not fully defined mechanism that may regulate the diffusion and storage of melatonin inside the cells (Venegas et al, ; Hevia et al, ).…”

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confidence: 99%

Diabetic Status Influences the Storage of Melatonin in Human Salivary Glands

Isola

Lilliu

Loy

et al. 2017

The Anatomical Record

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Recently we reported on the detailed localization of melatonin (and its receptors) in human salivary glands, revealing that serous cells are able to store and secrete melatonin into saliva. Since we found that type 2 diabetic patients display reduced melatonin content in saliva, our next step was to examine the presence of melatonin in salivary glands removed from type 2 diabetic subjects. The resulting data were compared with those previously obtained by identical procedures in non-diabetics, to establish if the diabetic status may affect melatonin distribution. Bioptic samples of diabetic parotid and submandibular glands were fixed, dehydrated, embedded in Epon Resin and processed to demonstrate melatonin reactivity by the immunogold staining method. The labeling density (expressed as the number of gold particles per μm /granule) and the percentage of melatonin-positive granules were assessed in diabetic samples. These values were compared with those in non-diabetic samples and differences were evaluated. In parotid and submandibular diabetic glands the reactivity for melatonin was specifically associated with secretory granules and small vesicles in serous cells. Melatonin reactivity was higher in parotid than in submandibular glands. Our data were in line with those obtained in our previous study on non-diabetic glands. Diabetic salivary glands showed a higher labeling density and a lower number of melatonin-positive granules compared to non-diabetic glands. Taken together, these data might explain the decreased salivary melatonin content and the associated oral problems observed in diabetics. Anat Rec, 301:711-716, 2018. © 2017 Wiley Periodicals, Inc.

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Oral Mucositis: Melatonin Gel an Effective New Treatment

Cited by 35 publications

References 145 publications

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Recent Progress of Basic Studies of Natural Products and Their Dental Application

Diabetic Status Influences the Storage of Melatonin in Human Salivary Glands

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