Oral Mucositis in Patients with Hematologic Malignancies Undergoing Chemotherapy

Sarmento, Viviane Almeida; Curi, Davi Silva Carvalho; Santos, Thaiane Dantas Dias dos; Rezende, Renata Portela de; Lins-Kusterer, Liliane; Ribeiro, Patrícia Miranda Leite

doi:10.1007/s42399-021-01000-4

Cited by 3 publications

(2 citation statements)

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“…Curra et al demonstrated that children exposed to high-dose MTX alone or in combination with cyclophosphamide and doxorubicin experienced a higher incidence and severity of OM. A similar observation was made by Saramento et al where the use of MTX and melphalan as a part of HSCT conditioning was associated with a higher incidence of OM [ 14 , 27 ]. Different CT protocols used for the treatment of childhood malignancies consist of drugs with different stomatotoxic potential, then this is something that needs to be taken into consideration while designing new clinical trials regarding OM prophylaxis.…”

Section: Discussionsupporting

confidence: 77%

“…Furthermore, some drugs used in different chemotherapy (CT) protocols display a higher cytotoxic potential than others, one example being methotrexate (MTX) alone or in combination with other agents. They are first used in the treatment of acute lymphoblastic leukemia (ALL)—the most common childhood malignancy—and conditioning regiments prior to HSCT [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Photobiomodulation for Chemotherapy-Induced Oral Mucositis in Pediatric Patients

et al. 2023

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Oral mucositis (OM) is a common side effect in patients undergoing chemotherapy (CT), especially in children due to their rapid epithelial mitotic rate. It has been associated with a significant reduction in life quality since it leads to pain, an inadequate intake of nutrients, an increased risk of opportunistic infections, and interruptions of CT. Photobiomodulation (PMB) with low-level laser therapy (LLLT) has shown faster healing, reduction in pain, and the reduced use of analgesic compared to placebo groups. The purpose of this review is to analyze and compare the existing clinical trials and identify their shortcomings in hope to make future research easier. Using MeSH terms and keywords, the Embase, Medline, and PubMed databases we searched for the period of the last 5 years. We identified a total of 15 clinical trials, with a total of 929 pediatric patients analyzed in this review. We compared different light sources and other laser technique characteristics used in clinical trials such as wavelength, energy and power density, spot size, irradiation time, PBM protocol, and OM evaluation. The main findings show inconsistent laser parameter quotations, differences in the PBM protocol along with a laser application technique, and a lack of clinical trials. Based on that, more studies with a high methodological quality should be conducted in order to provide a unified PBM protocol suitable for the pediatric population.

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Section: Discussionsupporting

confidence: 77%