Oral mucositis in children associated with hematopoietic stem cells transplant

Mubaraki, Sarah

doi:10.4103/sjos.sjoralsci_31_19

Cited by 3 publications

(6 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hematopoietic stem cell transplant (HSCT) is defined as the infusion of multipotent stem cells derived from bone marrow, cord blood or peripheral blood to reconstitute the hematopoietic system 1 . HSCT is used to treat several hematological disorders 2 .…”

Section: Introductionmentioning

confidence: 99%

“…HSCT is used to treat several hematological disorders 2 . Oral mucositis (OM) is one of the side‐effects developed post‐HSCT 1 . It is defined as an inflammation of oropharynx resulting from cancer therapy typically manifesting as atrophy, swelling, erythema and ulceration 1 .…”

Section: Introductionmentioning

confidence: 99%

“…Oral mucositis (OM) is one of the side‐effects developed post‐HSCT 1 . It is defined as an inflammation of oropharynx resulting from cancer therapy typically manifesting as atrophy, swelling, erythema and ulceration 1 . It affects 80% of children undergoing HSCT, 3 and usually occurs between two and 18 days following the initiation of the chemotherapy 2 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The efficacy of two different oral hygiene regimens on the incidence and severity of oral mucositis in pediatric patients receiving hematopoietic stem cell transplantation: A prospective interventional study

Mubaraki

Pani

Al-Seraihy

et al. 2020

Special Care in Dentistry

View full text Add to dashboard Cite

Aims This prospective interventional study aimed to assess the efficacy of supersaturated calcium phosphate rinse and the use of an extra‐soft toothbrush twice a day when added to the existing oral hygiene protocol regimen (0.12% chlorhexidine gluconate + 3% sodium bicarbonate + nystatin 5000 U/mL) in reducing the severity of oral mucositis among pediatric patients receiving chemotherapy for the hematopoietic stem cell transplant. Methods Forty‐five patients that received chemotherapy for the hematopoietic stem cell transplant were randomly allocated to three groups of 15 patients each. Group A was advised to follow the existing oral hygiene protocol regimen (Control), group B was advised to brush their teeth twice daily using an extra‐soft toothbrush and to follow the control regimen, and lastly group C was advised to use supersaturated calcium phosphate rinse and to follow the control regimen. Oral mucositis was recorded according to World Health Organization criteria from the day of admission (day 1) to the day of discharge (day 28). The incidence of oral mucositis between the three groups was compared using the Kruskall‐Wallis test while the severity of oral mucositis between the three groups was compared using a one‐way ANOVA test. Results The results of the study showed no significant difference in the incidence of oral mucositis between the three groups; however, there was a lower severity of oral mucositis in the supersaturated calcium phosphate rinse group when compared to the control group or the group who used an extra‐soft toothbrush with the control regimen. Conclusion Although marginally fewer cases and lower severity of oral mucositis was observed in the group using supersaturated calcium phosphate rinse, the lack of statistical significance suggests that the evidence for their use is not conclusive. The results of this study also showed that the introduction of an extra‐soft toothbrush into the oral hygiene regimen did not significantly reduce the incidence of oral mucositis and may actually be responsible for an increase in the severity of oral mucositis.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The efficacy of two different oral hygiene regimens on the incidence and severity of oral mucositis in pediatric patients receiving hematopoietic stem cell transplantation: A prospective interventional study

Mubaraki

Pani

Al-Seraihy

et al. 2020

Special Care in Dentistry

View full text Add to dashboard Cite

show abstract

“…The numbers were categorized into two categories, namely no mucositis at an OAG score <10 and mucositis at an OAG score ≥10. 11 The OAG was applied because this instrument is commonly used to measure levels of mucositis and is easy to aplly or assess.…”

Section: Methodsmentioning

confidence: 99%

Influences of oral cryotherapy on mucositis prevention in cancer patients with chemotherapy

Silaban

Nasution

Siregar

2020

JKKI

View full text Add to dashboard Cite

Background: A mucositis is the most common problem in a chemotherapy treatment and becomes a severe problem for patients who receive several cycles of chemotherapy. Effects of an oral mucositis that is not treated immediately or is less effective can affect quality of life of the patients. Pain experienced by them can cause problems in the mouth, for example inability to tolerate food or fluids (dysphagia) and decreases of nutritional status.Objective: This study is to identify effectiveness of oral cryotherapy on prevention of the mucositis in cancer patients with chemotherapy. Methods: This study used a quasi-experimental method with a pre and post-test for a control group. Its samples were 32 patients for an intervention group and a control group, taken by using a consecutive sampling technique. The mucositis was measured by using questionnaires of Oral Assessment Guide (OAG), and the obtained data was analysed by the Wilcoxon and Mann Whitney test. Results: This study found that 24 respondents were not affected by the mucositis at p-value=0.008 (p<0.05) in the post intervention in the intervention group, and there was a difference in values of the mucositis measured by the OAG at p-value=0.003 (p<0.05) in the post intervention in the both groups. Conclusion:The oral cryotherapy could prevent the mucositis in cancer patients with chemotherapy. Latar Belakang: Mukositis merupakan masalah yang paling umum dalam pengobatan kemoterapi dan menjadi masalah yang sangat serius bagi pasien yang menerima beberapa siklus pengobatan kemoterapi.Efek penanganan mukositis oral yang tidak segera ditangani atau kurang efektf akan mempengaruhi kualitas hidup pasien. Rasa sakit yang dialami pasien menyebabkan ketidaknyamanan pada mulut, ketidakmampuan untuk mentoleransi makanan dan cairan (disfagia) dan sampai akhirnya mengalami penurunan status gizi. Tujuan: Untuk mengidentifikasi efektivitas cryotherapy oral pada pencegahan dari mucositis pada pasien kanker yang sedang menjalani kemoterapi. Metode: Penelitian ini menggunakan metode eksperimen semu dengan pre-post test dengan kelompok kontrol. Sampel adalah 32 pasien untuk kelompok intervensi dan kelompok kontrol, diambil dengan menggunakan teknik consecutive sampling. Mucositis diukur dengan menggunakan kuesioner pada Oral Assessment Guide (OAG) sedangkan data dianalisis dengan uji Wilcoxon dan uji Mann Whitney. Hasil: Hasil menunjukkan, dalam post intervensi pada kelompok intervensi, 24 responden tidak terpengaruh oleh mucositis pada p-value = 0.008 (p <0.05); dalam pasca intervensi pada kedua kelompok, ada perbedaan

show abstract

“…OM is a predisposing factor for the development of further adverse implications, including an increased risk for local and systemic infections, poor nutrition and prolonged hospitalisation, as well as periodontal diseases, dental caries, dry mouth, trismus, dysphagia and dysgeusia (Mubaraki, 2019 ). Consequently, OM has a marked impact on the quality of life and cost of treatment (Mubaraki, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors of oral mucositis in paediatric patients undergoing haematopoietic stem cell transplantation

Alhussain¹,

Alkhayal

Ayas

et al. 2021

Oral Diseases

View full text Add to dashboard Cite

Background A complete understanding of oral mucositis (OM) is crucial to develop appropriate interventions to aid in the successful overall health outcome of paediatric patients undergoing haematopoietic stem cell transplantation (HSCT). Aims This study aimed at determining the prevalence and severity of OM and at identifying the predictive factors that might aggravate OM at one‐week, two‐week and three‐week post‐HSCT. Methods This retrospective, hospital‐based study reviewed the medical records of 170 paediatric patients, summarising the patients’ characteristics using descriptive statistics. Binary logistic regression was used to identify factors associated with the development of OM. Results At one‐week post‐HSCT, 41% of 140 patients (n = 49) had developed OM, this was reduced at two‐week (n = 36, 33%) and three‐week (n = 13, 19%) post‐HSCT. Univariate logistic regression revealed that patients with cancer (OR = 0.16, 95% CI = 0.05–0.54; p‐value = .003) had a significantly lower prevalence of OM. Younger patients with an average age of 7.9 years old (OR = 0.85, 95% CI = 0.75–0.97; p‐value = 0.013) and the presence of GvHD (OR = 2.37, 95% CI = 1.03–5.45, p‐value = 0.042) were significantly related to a higher prevalence of OM. Multivariable logistic regression confirmed that the risk of OM is lower in patients with cancer compared to those with immunodeficiency syndromes or hereditary blood diseases (OR = 0.18, 95% CI = 0.04–0.77; p‐value = .021). Conclusions This study identified a significantly lower prevalence of OM in patients with cancer compared to other conditions and that young recipients and those who developed GvHD were more likely to have OM.

show abstract

Oral mucositis in children associated with hematopoietic stem cells transplant

Cited by 3 publications

References 68 publications

The efficacy of two different oral hygiene regimens on the incidence and severity of oral mucositis in pediatric patients receiving hematopoietic stem cell transplantation: A prospective interventional study

The efficacy of two different oral hygiene regimens on the incidence and severity of oral mucositis in pediatric patients receiving hematopoietic stem cell transplantation: A prospective interventional study

Influences of oral cryotherapy on mucositis prevention in cancer patients with chemotherapy

Prevalence and risk factors of oral mucositis in paediatric patients undergoing haematopoietic stem cell transplantation

Contact Info

Product

Resources

About