Oral mucositis and microbial colonization in oral cancer patients undergoing radiotherapy and chemotherapy: A prospective analysis in a tertiary care dental hospital

Subramaniam, Nandhini; Muthukrishnan, Arvind

doi:10.1111/jicd.12454

Cited by 75 publications

(53 citation statements)

References 24 publications

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“…In general, microbial changes before and after RCHT may be explained by therapy-associated effects on highly proliferative (tumor), but also healthy proliferative tissue, including the mucosa of the upper respiratory tract. Endotoxins are released, penetrate the submucosa, and induce chemotactic activity on polymorphonuclear neutrophils and macrophages, leading to the activation of pro-inflammatory cytokines and progressive tissue destruction 7,16 . Thus, microbial changes can be explained by the application of RCHT in our cohort.…”

Section: Discussionmentioning

confidence: 99%

Preliminary insights into the impact of primary radiochemotherapy on the salivary microbiome in head and neck squamous cell carcinoma

Kumpitsch

Moissl-Eichinger

Pock

et al. 2020

Sci Rep

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Squamous cell carcinoma is the most common type of throat cancer. Treatment options comprise surgery, radiotherapy, and/or chemo(immuno)therapy. The salivary microbiome is shaped by the disease, and likely by the treatment, resulting in side effects caused by chemoradiation that severely impair patients’ well-being. High-throughput amplicon sequencing of the 16S rRNA gene provides an opportunity to investigate changes in the salivary microbiome in health and disease. In this preliminary study, we investigated alterations in the bacterial, fungal, and archaeal components of the salivary microbiome between healthy subjects and patients with head and neck squamous cell carcinoma before and close to the end point of chemoradiation (“after”). We enrolled 31 patients and 11 healthy controls, with 11 patients providing samples both before and after chemoradiation. Analysis revealed an effect on the bacterial and fungal microbiome, with a partial antagonistic reaction but no effects on the archaeal microbial community. Specifically, we observed an individual increase in Candida signatures following chemoradiation, whereas the overall diversity of the microbial and fungal signatures decreased significantly after therapy. Thus, our study indicates that the patient microbiome reacts individually to chemoradiation but has potential for future optimization of disease diagnostics and personalized treatments.

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Section: Discussionmentioning

confidence: 99%

Preliminary insights into the impact of primary radiochemotherapy on the salivary microbiome in head and neck squamous cell carcinoma

Kumpitsch

Moissl-Eichinger

Pock

et al. 2020

Sci Rep

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“…(Ariyawardana and Vithanaarachchi 2005). Our recent research have features as numerous articles in reputed journals (Subramaniam and Muthukrishnan 2019;Vadivel et al 2019;Santosh rayagouda Patil et al 2020;Santosh r. Patil et al 2018;S. r. Patil et al 2018).…”

Section: Inclusion Criteriamentioning

confidence: 96%

Awareness of Oral Cancer Among Dental Students - A Survey

Chandrasekar¹

2020

Biosci. Biotech. Res. Comm

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Oral cancer represents one of the most common malignancies. The objective of this survey was to assess the awareness and determine the understanding of oral cancer among dental students This study was conducted based on a questionnaire which consist of 10 questions through a web-linked application called Survey Monkey. A puposive random sample size of 100 dental students from Chennai participated in the study. The overall awareness of oral cancer was good with the vast majority being aware of the family history, role of Human Papilloma Virus(HPV), screening aids for oral cancer. A statistical analysis was done with SPSS to look for gender based differences and it was found there was a statistically significant difference in between the genders for the common site of oral cancer and the role played by HPV. As a conclusion, the majority of the dental students within the study were aware of the term oral cancer. However, this study was limited to one particular institute. Further, study should be conducted in a larger scale area and sample size to get a proper overview regarding this topic within the general public concerning the new advent technologies.

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“…The study on the combination of both antioxidant and cytotoxic effects of Selenium nanoparticles as a subject is the uniqueness of our study. Our recent research portfolio slides numerous articles in reputed journals [22][23][24][25][26][27][28][29][30]. Based on this experience we planned to pursue the cytotoxicity and antioxidant property of Selenium nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidant and Cytotoxic Effect of Selenium Nanoparticles Synthesised Using Capparis decidua

Lakshme

Preetha

Jeevitha

et al. 2020

JPRI

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Background: Among the nanoparticles, selenium nanoparticles (SeNP) are one of the most extensively studied as Selenium has zero oxidation state, non toxic and biologically inert material. This is the reason why Selenium is considered as a major nanoparticulate. In this study SeNPs were extracted from the fruit of Capparis decidua which is a xerophytic small herb. Aim: The aim of the present study is to evaluate the cytotoxic effect and antioxidant capacity of selenium nanoparticles. Materials and Methods: In this study SeNPs were extracted from the fruit of Capparis decidua which is a xerophytic small herb. The cytotoxic effect of SeNPs was evaluated using Brine Shrimp assay and the antioxidant activity was determined using DPPH assay considering ascorbic acid as the standard. Results: From the study of this assay the shrimps introduced into the well were almost alive in different concentrations and this indicates that there is no cytotoxicity in selenium nanoparticles. The percentage inhibition of Selenium nanoparticles in 10 µl was 15.4 0.1, 20 µl was 38.36 0.15, 30 µl was 45.3 0.1, 40 µl was 59.6 0.15 and 50 µl was 65.6 0.1. It can be inferred that percentage inhibition increases with increase in concentration but it was less when compared to the percentage inhibition of the standard. Conclusion: The selenium nanoparticles extracted from Capparis decidua do not have any cytotoxic effect on shrimps. The SeNPs possessed significant antioxidant activity in increasing concentrations compared to the standard used. Thus SeNPs are biologically useful and can be used as eco-friendly, cost effective and efficient biomedical agents and therapeutics.

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Oral mucositis and microbial colonization in oral cancer patients undergoing radiotherapy and chemotherapy: A prospective analysis in a tertiary care dental hospital

Cited by 75 publications

References 24 publications

Preliminary insights into the impact of primary radiochemotherapy on the salivary microbiome in head and neck squamous cell carcinoma

Preliminary insights into the impact of primary radiochemotherapy on the salivary microbiome in head and neck squamous cell carcinoma

Awareness of Oral Cancer Among Dental Students - A Survey

Evaluation of Antioxidant and Cytotoxic Effect of Selenium Nanoparticles Synthesised Using Capparis decidua

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