Oral Mucosa Tissue Response to Titanium Cover Screws

Olmedo, Daniel Gustavo; Paparella, María Luisa; Spielberg, M; Brandizzi, Daniel; Guglielmotti, M.B.; Cabrini, R. L.

doi:10.1902/jop.2011.110392

Cited by 73 publications

(91 citation statements)

References 42 publications

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“…Under normal conditions, the gingival tissue is composed of healthy oral epithelium and connective tissue along with varying percentages of inflammatory cells. Based on the results of the present study at all evaluated tissue levels, the presence of small (<10 mm) and large (>30 mm) metallic particles was confirmed, consistent with the results of the studies by Flatebo et al [10] and Olmedo et al, [8] indicating signs of release of metals from implants into the gingival tissues overlying the implants in a large number of patients. One of the concerns in relation to dental implants is the local corrosion of the cover screw components into its overlying soft tissues and the possible complications, such as induction of allergic and inflammatory reactions, or the premature exposure of the implant into the oral cavity.…”

Section: Resultssupporting

confidence: 92%

“…In the studies carried out by Flatebo et al [10] and Olmedo et al, [8] the connective tissue adjacent to the cover screw exhibited a maximum number of metallic particles. In this study, the presence of metallic particles with different sizes in the most superficial layer of the soft tissue overlying the cover screw indicated that the corrosion of the components of the cover screw was not confined to the contact area of the overlying connective tissue.…”

Section: Resultsmentioning

confidence: 95%

“…Based on a study by Olmedo et al, [8] the sample size was calculated at minimum 81 biopsy samples at a D 0.05, b D 0.2 and mean standard deviation (SD) D 3.3, in order to determine a mean difference of 2.5. However, 96 biopsy samples were included in the present study.…”

Section: Sample Sizementioning

confidence: 99%

“…All the samples were over 0.3 cm in size. [8] The gingival tissue sample was placed in 10% formalin for 48 h, followed by rinsing with water, trimming, dehydrating in ethyl alcohol and immersing in paraffin. The samples underwent a staining procedure with hematoxylin and eosin (H&E) to evaluate the presence of metallic particles.…”

Section: Procedural Stepsmentioning

confidence: 99%

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Histopathological evaluation of gingival tissue overlying two-stage implants after placement of cover screws

Paknejad

Bayani

Yaghobee

et al. 2015

Biotechnology & Biotechnological Equipment

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Corrosion of implant components, including that of cover screws, has been reported as a possible etiological factor for implant failure. This study evaluated the presence of metallic particles in the soft tissues overlying two-stage implants after placing cover screws, by using a histological technique and energy-dispersive X-ray spectroscopy. The results showed large and small titanium particles in different layers of the soft tissue overlying the implant and cover screws in the majority of samples, with more particles near the cover screws. These particles might have contributed to the various degrees of inflammatory reactions detected in the different layers of the overlying soft tissues. Further studies on the corrosion of implants' metallic components are recommended, so that the implant failure rates could be minimized.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 95%

Section: Sample Sizementioning

confidence: 99%

Section: Procedural Stepsmentioning

confidence: 99%

See 2 more Smart Citations

Histopathological evaluation of gingival tissue overlying two-stage implants after placement of cover screws

Paknejad

Bayani

Yaghobee

et al. 2015

Biotechnology & Biotechnological Equipment

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“…In this context, 153 patients rehabilitated with single implants underwent biopsy of the mucosa adjacent to the implant cover screws during the period of osseointegration (4–6 months). In total, 41% of these patients showed Ti particles released from the implant surface, sometimes free or surrounded by macrophages, denoting foreign body reaction with probable metal corrosion [30].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dextrose and Lipopolysaccharide on the Corrosion Behavior of a Ti-6Al-4V Alloy with a Smooth Surface or Treated with Double-Acid-Etching

et al. 2014

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Diabetes and infections are associated with a high risk of implant failure. However, the effects of such conditions on the electrochemical stability of titanium materials remain unclear. This study evaluated the corrosion behavior of a Ti-6Al-4V alloy, with a smooth surface or conditioned by double-acid-etching, in simulated body fluid with different concentrations of dextrose and lipopolysaccharide. For the electrochemical assay, the open-circuit-potential, electrochemical impedance spectroscopy, and potentiodynamic test were used. The disc surfaces were characterized by scanning electron microscopy and atomic force microscopy. Their surface roughness and Vickers microhardness were also tested. The quantitative data were analyzed by Pearson's correlation and independent t-tests (α = 0.05). In the corrosion parameters, there was a strong lipopolysaccharide correlation with the Ipass (passivation current density), Cdl (double-layer capacitance), and Rp (polarization resistance) values (p<0.05) for the Ti-6Al-4V alloy with surface treatment by double-acid-etching. The combination of dextrose and lipopolysaccharide was correlated with the Icorr (corrosion current density) and Ipass (p<0.05). The acid-treated groups showed a significant increase in Cdl values and reduced Rp values (p<0.05, t-test). According to the topography, there was an increase in surface roughness (R2 = 0.726, p<0.0001 for the smooth surface; R2 = 0.405, p = 0.036 for the double-acid-etching-treated surface). The microhardness of the smooth Ti-6Al-4V alloy decreased (p<0.05) and that of the treated Ti-6Al-4V alloy increased (p<0.0001). Atomic force microscopy showed changes in the microstructure of the Ti-6Al-4V alloy by increasing the surface thickness mainly in the group associated with dextrose and lipopolysaccharide. The combination of dextrose and lipopolysaccharide affected the corrosion behavior of the Ti-6Al-4V alloy surface treated with double-acid-etching. However, no dose-response corrosion behavior could be observed. These results suggest a greater susceptibility to corrosion of titanium implants in diabetic patients with associated infections.

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Reversible, non‐plaque‐induced marginal bone loss around an osseointegrated implant: A case report

Lind

Ulvik

Berg

et al. 2022

Clinical Case Reports

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Oral Mucosa Tissue Response to Titanium Cover Screws

Cited by 73 publications

References 42 publications

Histopathological evaluation of gingival tissue overlying two-stage implants after placement of cover screws

Histopathological evaluation of gingival tissue overlying two-stage implants after placement of cover screws

Effects of Dextrose and Lipopolysaccharide on the Corrosion Behavior of a Ti-6Al-4V Alloy with a Smooth Surface or Treated with Double-Acid-Etching

Reversible, non‐plaque‐induced marginal bone loss around an osseointegrated implant: A case report

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