Oral Mucosa Tissue Equivalents for the Treatment of Limbal Stem Cell Deficiency

O’Callaghan, Anna R.; Dziasko, Marc; Sheth‐Shah, Radhika; Lewis, Mark P.; Daniels, Julie T.

doi:10.1002/adbi.201900265

Cited by 5 publications

(2 citation statements)

References 48 publications

(47 reference statements)

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“…Oral mucosa is an alternate cell source 118–120 . Alternative scaffolds to amniotic membrane have been suggested including collagen I biomaterials 121,122 . A fibrin matrix with cultured autologous LSC was the first stem cell treatment approved in the European Union 123 .…”

Section: Methods To Increase Supply or Limit Need For Corneal Donor Tissuementioning

confidence: 99%

Corneal supply and the use of technology to reduce its demand: A review

Baird

Machin

Brown

2021

Clinical Exper Ophthalmology

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Recovery and access to end‐of‐life corneal tissue for corneal transplantation, training and research is globally maldistributed. The reasons for the maldistribution are complex and multifaceted, and not well defined or understood. Currently there are few solutions available to effectively address these issues. This review provides an overview of the system, key issues impacting recovery and allocation and emphasises how end‐user ophthalmologists and researchers, with support from administrators and the wider sector, can assist in increasing access long‐term through sustaining eye banks nationally and globally. We posit that prevention measures and improved surgical techniques, together with the development of novel therapies will play a significant role in reducing demand and enhance the equitable allocation of corneas.

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Section: Methods To Increase Supply or Limit Need For Corneal Donor Tissuementioning

confidence: 99%

Corneal supply and the use of technology to reduce its demand: A review

Baird

Machin

Brown

2021

Clinical Exper Ophthalmology

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“…Alternative cell populations: Compared with traditional transplants, the application of alternative cell populations avoids corneal donor shortages and the risk of disease transmission, graft rejection and tumours (due to immunosuppressant application) associated with allografts, which makes it possible to replace traditional transplants. Currently, the alternative cell populations include oral mucosal epithelial cells[ 135 , 136 ], human embryonic stem cells (HESCs)[ 137 ], induced pluripotent stem cells (iPSCs)[ 138 , 139 ], mesenchymal stem cells (MSCs)[ 140 , 141 ], human immature dental pulp stem cells[ 142 , 143 ], etc. Among these alternatives, MSCs and iPSCs are of vital importance and will be described in detail.…”

Section: Corneal Epithelial Stem Cellsmentioning

confidence: 99%

Profile of biological characterizations and clinical application of corneal stem/progenitor cells

Ying¹,

Fu²,

Huang³

et al. 2022

World J Stem Cells

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Corneal stem/progenitor cells are typical adult stem/progenitor cells. The human cornea covers the front of the eyeball, which protects the eye from the outside environment while allowing vision. The location and function demand the cornea to maintain its transparency and to continuously renew its epithelial surface by replacing injured or aged cells through a rapid turnover process in which corneal stem/progenitor cells play an important role. Corneal stem/progenitor cells include mainly corneal epithelial stem cells, corneal endothelial cell progenitors and corneal stromal stem cells. Since the discovery of corneal epithelial stem cells (also known as limbal stem cells) in 1971, an increasing number of markers for corneal stem/progenitor cells have been proposed, but there is no consensus regarding the definitive markers for them. Therefore, the identification, isolation and cultivation of these cells remain challenging without a unified approach. In this review, we systematically introduce the profile of biological characterizations, such as anatomy, characteristics, isolation, cultivation and molecular markers, and clinical applications of the three categories of corneal stem/progenitor cells.

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