Oral Mucosa as a Reservoir of Human Papillomavirus: Point Prevalence, Genotype Distribution, and Incident Infections Among Males in a 7-year Prospective Study

Kero, Katja; Rautava, Jaana; Syrjänen, Kari; Grénman, Seija; Syrjänen, Stina

doi:10.1016/j.eururo.2012.06.045

Cited by 61 publications

(51 citation statements)

References 27 publications

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“…Oral-genital contact: Several studies have shown that individuals with a higher number of oral sex partners are more likely to have: Prevalent oral HPV infection 38, 39 Incident oral HPV infection 43 HPV-associated head and neck cancer 44, 45 This suggests that HPV is likely transmitted by oral sex. However, it is important to understand that many sexual behaviors are collinear (i.e.…”

Section: Reaction To Hpv-positive Testmentioning

confidence: 99%

Discussing the diagnosis of HPV-OSCC: Common questions and answers

Fakhry

D’Souza

2013

Oral Oncology

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Human papillomavirus (HPV) is responsible for a rising proportion of oropharyngeal squamous cell cancers (OSCC). HPV-positive OSCCs (HPV-OSCC) are associated with oral HPV infection and sexual behavior. Patient questions regarding risk factors, prognosis and implications for past, present and future relationships often arise. This manuscript addresses frequently asked questions by patients with HPV-OSCC and their families. A framework for clinicians to address these conversations and the limitations of our present knowledge base is also presented. HPV and its role in OSCCHuman papillomavirus (HPV), a sexually transmitted infection, is now responsible for the overwhelming majority of oropharyngeal squamous cell cancers (OSCC) in the United States (U.S.). Historically, tobacco and alcohol use accounted for the majority of head and neck cancers. However, with the decline of tobacco use in the U.S., the incidence of smoking-related (HPV-negative) oropharyngeal malignancies has decreased. 1 The proportion of oropharyngeal cancers attributable to HPV (HPV-positive OSCC; HPV-OSCC) has risen substantially in the U.S. Indeed, while only 16% of OSCCs in the 1980s were HPV-positive, approximately 73% of tumors in the 2000s were HPV-positive. Not only is the proportion of OSCCs that are HPV-positive rising, but the incidence of OSCC is also rising. From 1988 to 2004, there was a 28% increase in incidence of OSCC in the U.S., which was primarily among younger men, ages 50-59. 1 Currently, the incidence of OSCC in the U.S. is 6.2 per 100,000, and 1.4 per 100,000 among men and women, respectively. 2 There is also data emerging that HPV is etiologically associated with a smaller subset of oral cavity tumors. 3 HPV-OSCC has been recognized in the past 10 years as a distinct disease entity. These cancers are associated with oral HPV infection and sexual behavior (a surrogate for oral HPV exposure), although HPV-OSCC is diagnosed in many people who have a modest number of lifetime sexual partners. Individuals with HPV-OSCC, when compared to those with HPV-negative tumors, tend to be white, male, non-smokers and non-drinkers. 4 Patients with HPV-OSCC have significantly better prognosis than those with HPV-negative Corresponding Authors. Carole Fakhry and Gypsyamber D'Souza, 615 N Wolfe St. E6132, Baltimore, MD

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Section: Reaction To Hpv-positive Testmentioning

confidence: 99%

Discussing the diagnosis of HPV-OSCC: Common questions and answers

Fakhry

D’Souza

2013

Oral Oncology

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“…[23][24][25][26][27][28] Notably, the prevalence of HPV seems to be significantly higher in men than in women. [25][26][27]29 Furthermore, high-risk sexual behavior including oral-genital sex has been found to be associated with transmission of HPV infections between oral and genital sites. 26,30,31 Immunodeficiency (e.g.…”

Section: Hpv Infection Of the Oral Cavitymentioning

confidence: 99%

HPV and cancer of the oral cavity

2015

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“…Initial studies indicate that oral HPV infection is associated with sexual behaviour and immunosuppression, and the incidence of OSCC related to HPV has significantly increased in the male population [3]. In patients infected with human immunodeficiency virus (HIV), oral HPV infections seem to persist for longer than in the healthy population [4], increasing the risk of developing oropharyngeal cancer [5].Most of the information available about oral HPV infection is based on women and men who have sex with men (MSM) with or without HIV infection [6,7] and on healthy young men [8,9]. However, data reported on heterosexual HIV-infected men are scarce [10,11].…”

mentioning

confidence: 99%

Oral human papillomavirus type-specific infection in HIV-infected men: a prospective cohort study among men who have sex with men and heterosexual men

Darwich

Cañadas

Videla

et al. 2014

Clinical Microbiology and Infection

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The natural history of type-specific oral infection of human papillomavirus (HPV) was assessed in a cohort of HIV-infected men (538 men who have sex with men (MSM); 195 heterosexuals). Risk factors associated with oral HPV infections were examined. The overall prevalence of HPV was 16%: HPV-16 was the most prevalent type (3.7% MSM; 7.8% heterosexuals). The prevalence of HPV-16 in heterosexuals was associated with CD4 nadir counts <200 cells/μL (ORadjusted = 3.0, 95% CI, 1.4-6.3). The overall incidence of HPV was similar between groups (11%), but the incidence of HPV-16 was higher in heterosexuals (ORadjusted = 3.2, 95% CI, 1.1-9.5). Not only MSM but also HIV-infected heterosexual men are at risk of HPV infection. Regular and careful oral inspection is needed.

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Oral Mucosa as a Reservoir of Human Papillomavirus: Point Prevalence, Genotype Distribution, and Incident Infections Among Males in a 7-year Prospective Study

Cited by 61 publications

References 27 publications

Discussing the diagnosis of HPV-OSCC: Common questions and answers

Discussing the diagnosis of HPV-OSCC: Common questions and answers

HPV and cancer of the oral cavity

Oral human papillomavirus type-specific infection in HIV-infected men: a prospective cohort study among men who have sex with men and heterosexual men

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