Oral mucormycosis in post‐COVID‐19 patients: A case series

Ahmed, Enji; Abou‐Bakr, Asmaa; Hussein, Radwa R; El‐Gawish, Ayman A.; Ras, Abou‐bakr E.; Ghalwash, Dalia

doi:10.1111/odi.13973

Cited by 14 publications

(16 citation statements)

References 10 publications

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“…They observed that in COVID-19 individuals, oral signs of mucormycosis are often evident in the palate and may include varied degrees of mucosal staining, swelling, ulcerations, superficial necrotic regions in the palate, bone exposure, and necrosis with black eschar development. As a result, palatal ulcerations may be the first presenting symptom, prompting the patient to seek treatment from a dentist, who may be the first clinician to identify an infection, leading to the diagnosis of mucormycosis [115].…”

Section: Oral and Dental Manifestationsmentioning

confidence: 99%

Dental and Oral Manifestations of COVID-19 Related Mucormycosis: Diagnoses, Management Strategies and Outcomes

Janjua

Shaikh

Fareed

et al. 2021

JoF

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It has been nearly two years since the pandemic caused by the novel coronavirus disease (COVID-19) has affected the world. Several innovations and discoveries related to COVID-19 are surfacing every day and new problems associated with the COVID-19 virus are also coming to light. A similar situation is with the emergence of deep invasive fungal infections associated with severe acute respiratory syndrome 2 (SARS-CoV-2). Recent literature reported the cases of pulmonary and rhino-cerebral fungal infections appearing in patients previously infected by COVID-19. Histopathological analysis of these cases has shown that most of such infections are diagnosed as mucormycosis or aspergillosis. Rhino-orbital-cerebral mucormycosis usually affects the maxillary sinus with involvement of maxillary teeth, orbits, and ethmoidal sinuses. Diabetes mellitus is an independent risk factor for both COVID-19 as well as mucormycosis. At this point, there is scanty data on the subject and most of the published literature comprises of either case reports or case series with no long-term data available. The aim of this review paper is to present the characteristics of COVID-19 related mucormycosis and associated clinical features, outcome, diagnostic and management strategies. A prompt diagnosis and aggressive treatment planning can surely benefit these patients.

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Section: Oral and Dental Manifestationsmentioning

confidence: 99%

Dental and Oral Manifestations of COVID-19 Related Mucormycosis: Diagnoses, Management Strategies and Outcomes

Janjua

Shaikh

Fareed

et al. 2021

JoF

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“…Among ulcerative lesions ( n=57 ), most of them there were no specific cause ( 44/57; 77.2 %), others were correlated with herps simplex virus (HSV) co-infection ( 5/57; 8.7% ), [11] , [12] , [13] or Enterococcus faecalis and/or Pseudomonas aeruginosa bacteria ( 2/57; 3.5 %) [14] or associated with fungi as candidiasis ( 6/57; 10.5 %) [15] , [16] , [17] , [18] and mucormycosis ( 23/116; 19.5 %). [19] , [20] , [21] …”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, fewer cases occurred during post-acute COVID-19 infection. [ 21 , 30 , 31 ] There still little evidence about the real cause of these oral lesions related to post-acute COVID-19. Ulceration[ 21 , 30 ], erosion and a verrucous leucoplakia [31] were described, and authors suggested as a probable hypothesis the SARS-CoV-2 capacity in leading to reactivation of viruses like the herpes virus ' family.…”

Section: Discussionmentioning

confidence: 99%

“…[ 21 , 30 , 31 ] There still little evidence about the real cause of these oral lesions related to post-acute COVID-19. Ulceration[ 21 , 30 ], erosion and a verrucous leucoplakia [31] were described, and authors suggested as a probable hypothesis the SARS-CoV-2 capacity in leading to reactivation of viruses like the herpes virus ' family. [ 30 , 31 ] Despite evidence about the presence of SARS-CoV-2 in oral tissue [29] , more studies are still needed to understand the pathogenesis of oral lesions related to COVID-19 and secondary causes cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

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Oral mucosa lesions in confirmed and non-vaccinated cases for COVID-19: A systematic review

Santana

Vieira²,

Gonçalo³

et al. 2022

Journal of Stomatology, Oral and Maxillofacial Surgery

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“…7 The oral manifestations of rhinocerebral mucormycosis are described as blackish discolouration of palatal mucosa, pressure ulcers in the palate or oor of the mouth, presence of necrotizing plaque, gingival abscess, and development of sudden mobility of teeth. 8,9 Aggressive surgical debridement and resection of involved areas create defects that compromise function and aesthetics. This article describes the diagnosis and management with emphasis on oral rehabilitation of a case of post-COVID-19 rhino-cerebral mucormycosis.…”

Section: Introductionmentioning

confidence: 99%

Management of Post COVID-19 Rhino cerebral Mucormycosis: A case report

Kumar¹,

Sharma²,

Chawla³

et al. 2022

Preprint

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Mucormycosis is a life-threatening, opportunistic, deep fungal infection frequently evident in patients with moderate to severe forms of COVID-19. It is usually detected within 2-8 weeks after the onset of symptoms and is categorized into six types depending on its location. The rhinocerebral form is most prevalent and involves orofacial structures. The fulminant nature of Mucormycosis necessitates rapid diagnosis and aggressive multidisciplinary treatment planning. This report presents a case of post-COVID-19 rhinocerebral Mucormycosis, where the failure to identify the disease by the dentist led to treatment delay. The patient was successfully managed by a combined approach of surgical debridement and systemic antifungal drug administration. The function and esthetics were restored by prosthetic rehabilitation. Etiopathogenesis of post-COVID-19 Mucromycosis and the dentist’s role in the diagnosis and treatment of mucormycosis following COVID-19 infection is discussed.

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Oral mucormycosis in post‐COVID‐19 patients: A case series

Abstract: We would like to acknowledge the contributions of the oral maxillo-facial and ENT specialties for helping us to reach the final diagnosis.

Cited by 14 publications

References 10 publications

Dental and Oral Manifestations of COVID-19 Related Mucormycosis: Diagnoses, Management Strategies and Outcomes

Dental and Oral Manifestations of COVID-19 Related Mucormycosis: Diagnoses, Management Strategies and Outcomes

Oral mucosa lesions in confirmed and non-vaccinated cases for COVID-19: A systematic review

Management of Post COVID-19 Rhino cerebral Mucormycosis: A case report

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