Oral Montelukast Compared with Inhaled Salmeterol To Prevent Exercise-Induced Bronchoconstriction

Edelman, Jonathan M.; Turpin, Jennifer; Bronsky, Edwin A.; Grossman, Jay; Kemp, James P.; Ghannam, Asma F.; DeLucca, Paul; Gormley, Glenn J.; Pearlman, David S.

doi:10.7326/0003-4819-132-2-200001180-00002

Cited by 186 publications

(90 citation statements)

References 26 publications

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“…For those subjects, leukotriene receptor antagonists may be more suitable since they are as effective as long-acting β 2 agonists in this setting (49,65) and do not loose their protective effect when used on a regular basis (63)(64)(65). In addition, the response to rescue short-acting β 2 agonists after exercise is fully maintained during regular treatment with leukotriene receptor antagonists, which may not be true during treatment with regular β 2 agonists (65,66).…”

Section: Cold Air-provoked Short-term Responsesmentioning

confidence: 99%

“…As inhaled long-acting β 2 agonists rapidly loose their protective effect on exercise-provoked asthma when used on a regular basis (62)(63)(64), their use may not be advocated in subjects who exercise regularly in cold weather. For those subjects, leukotriene receptor antagonists may be more suitable since they are as effective as long-acting β 2 agonists in this setting (49,65) and do not loose their protective effect when used on a regular basis (63)(64)(65).…”

Section: Cold Air-provoked Short-term Responsesmentioning

confidence: 99%

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Cold air-provoked respiratory symptoms: the mechanisms and management

Koskela

2007

International Journal of Circumpolar Health

185

137

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Objectives. To describe the mechanisms and management of cold air-provoked respiratory symptoms. Study design. A literature review. Methods. The review includes human epidemiological studies, human and animal experimental studies, as well as human studies about management of the cold air-provoked respiratory symptoms. Results. Cold air is unlikely to be a causal factor initiating respiratory diseases but a symptom trigger. In the present review, the airway responses beyond these symptoms were divided into three types. The short-term responses are those that develop within minutes in response to sudden cooling of the airways. Subjects with asthma or rhinitis are especially prone to these responses. The long-term responses are those that develop in response to repeated and longstanding cooling and drying of the airways, usually in endurance athletes. Finally, there are the physiological, reflex-mediated lower-airway responses to cooling of the skin or upper airways. Conclusions. The mechanisms beyond cold air-provoked respiratory symptoms vary considerably and mainly depend on the individual's susceptibility and the ventilation level during the cold exposure. An understanding of these mechanisms is essential for successful management of the symptoms. (Int J Circumpolar Health 2007; 66(2) [91][92][93][94][95][96][97][98][99][100]

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Section: Cold Air-provoked Short-term Responsesmentioning

confidence: 99%

Section: Cold Air-provoked Short-term Responsesmentioning

confidence: 99%

Cold air-provoked respiratory symptoms: the mechanisms and management

Koskela

2007

International Journal of Circumpolar Health

185

137

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“…Montelukast reduces the % fall in FEV 1 by 40-60% and reduces the time of recovery of FEV 1 to pre-exercise levels. Furthermore, no tolerance develops to this drug when it is used daily [11]. However, not all subjects have their EIB significantly inhibited by montelukast.…”

Section: Editorialmentioning

confidence: 99%

The prevention of exercise-induced bronchoconstriction: what are the options?

Anderson

2012

Expert Review of Respiratory Medicine

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“…Repeated administration with β2-agonists results in tachyphylaxis, whereas that of LTRA does not. Montelukast persistently prevents EIB even after four and eight weeks of administration, whereas the preventive effects of salmeterol, a LABA, were attenuated [38]. aspirin-intolerant, than tolerant asthma [39].…”

Section: Exercise Induced Bronchoconstriction (Eib)mentioning

confidence: 99%

Leukotriene receptor antagonists pranlukast and montelukast for treating asthma

Matsuse

Kohno

2013

Expert Opinion on Pharmacotherapy

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IntroductionThe prevalence of bronchial asthma, which is a chronic inflammatory disorder of the airway, is increasing worldwide. Although inhaled corticosteroids (ICS) play a central role in the treatment of asthma, they cannot achieve good control for all asthmatics and medications such as leukotriene receptor antagonists (LTRAs) with bronchodilatory and anti-inflammatory effects often serve as alternatives or add-on drugs. Several issues such as predicted responses, effects of peripheral airway and airway remodeling and alternative administration routes remain to be clarified before LTRAs PAGE 3 could serve a more effective role in the treatment of asthma. Areas covered

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Oral Montelukast Compared with Inhaled Salmeterol To Prevent Exercise-Induced Bronchoconstriction

Cited by 186 publications

References 26 publications

Cold air-provoked respiratory symptoms: the mechanisms and management

Cold air-provoked respiratory symptoms: the mechanisms and management

The prevention of exercise-induced bronchoconstriction: what are the options?

Leukotriene receptor antagonists pranlukast and montelukast for treating asthma

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