“…A number of theories have been advanced to explain the relationship between antibiotic therapy and moniliasis, among them that of Paine (1952), who introduced the idea that intestinal infections with C. albicans might result from the removal of a normal inhibition of this organism by Escherichia coli. Lighterman (1951), also emphasizing the destruction of the intestinal flora by the antibiotic, suggested that the resulting B-vitamin deficiency might predispose to oral moniliasis.…”