Oral minoxidil use in androgenetic alopecia and telogen effluvium

Feaster, Brittany; Onamusi, Toluwalashe; Cooley, Jerry E.; McMichael, Amy J.

doi:10.1007/s00403-022-02331-5

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…Similarly, minoxidil, a pharmacologic agent that relaxes blood vessels and increases blood flow, has been widely utilized for the management of AnA. While topical minoxidil has been FDA approved for MPAnA and FMPAnA, oral minoxidil, especially in a low dose, is used off-label for AA and TE [93][94][95].…”

Section: Minoxidilmentioning

confidence: 99%

Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

Natarelli

Gahoonia

Sivamani

2023

JCM

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The hair cycle is composed of four primary phases: anagen, catagen, telogen, and exogen. Anagen is a highly mitotic phase characterized by the production of a hair shaft from the hair follicle, whereas catagen and telogen describe regression and the resting phase of the follicle, respectively, ultimately resulting in hair shedding. While 9% of hair follicles reside in telogen at any time, a variety of factors promote anagen to telogen transition, including inflammation, hormones, stress, nutritional deficiency, poor sleep quality, and cellular division inhibiting medication. Conversely, increased blood flow, direct stimulation of the hair follicle, and growth factors promote telogen to anagen transition and subsequent hair growth. This review seeks to comprehensively describe the hair cycle, anagen and telogen balance, factors that promote anagen to telogen transition and vice versa, and the clinical utility of a variety of lab testing and evaluations. Ultimately, a variety of factors impact the hair cycle, necessitating a holistic approach to hair loss.

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Section: Minoxidilmentioning

confidence: 99%

Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

Natarelli

Gahoonia

Sivamani

2023

JCM

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“…Common barriers for the use of topical minoxidil in male and female-patterned hair loss (FPHL) include the development of pruritus, contact dermatitis, change in hair texture, and localized hypertrichosis. [ 2 3 ]…”

Section: Advantages Of Oral Minoxidil Over Topical Minoxidilmentioning

confidence: 99%

“…Patterned hair loss is the most common cause of alopecia, typically presenting with progressive thinning, miniaturization, and loss of hair at classical topography depending on the sex of the patient. [ 1 2 3 ] Male-patterned hair loss (MPHL) and female-patterned hair loss (FPHL) affects up to 50% of males over 50 and postmenopausal women, respectively. [ 2 ] Since described, little has changed regarding its treatment.…”

Section: Introductionmentioning

confidence: 99%

Role of oral minoxidil in patterned hair loss

Ramírez-Marín

Tosti

2022

Indian Dermatol Online J

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Recent studies have shown that low-dose oral minoxidil (OM) can be a safe and effective treatment of numerous hair disorders including male-patterned hair loss (MPHL) and female-patterned hair loss (FPHL). There are several practical advantages of OM over its topical formulation: enhanced cosmesis, cost-savings, and the possibility of co-therapy with other topical formulations or topicals used for camouflage. This treatment may be particularly helpful for patients who are unable to tolerate topical minoxidil or other systemic treatments. Doses ranging from 0.25 to 1.25 mg daily are usually used for FPHL and doses ranging from 2.5 to 5 mg/day for MPHL. The low side-effect profile of low-dose OM allows for long-term adherence to the medication and favorable clinical response, resulting in stabilization and improvement of hair loss. More studies are needed to test the efficacy of OM in other types of alopecia as well as additional comparative studies assessing OM to other commonly used medications.

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“…Facial hypertrichosis and dizziness due to postural hypotension were noted in five patients (out of 36). A multicenter retrospective analysis done by Feaster et al 18 studied 0.625–2.5 mg oral minoxidil for 1 year period in 105 patients of telogen effluvium and male androgenic alopecia patients with marked improvement and stabilization of the disease process. Similar findings were noted by Sinclair et al, 19 albeit hypertrichosis and cardiac side effects contributed to the discontinuation of the drug in few patients.…”

Section: Chronic Telogen Effluviummentioning

confidence: 99%

Comprehensive review of oral minoxidil in alopecia

Modha

Pathania

2022

J of Cosmetic Dermatology

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Background: There have been various treatment modalities available for alopecia in the form of topical and systemic with a variable response. The compliance of the patients is important in reaping results in alopecia. Minoxidil has come a long-way finding its use from topical formulations to systemic at lower dose in different alopecia.Objective: The objective of this article is to discuss various conditions in alopecia where oral minoxidil has found its role.Methods: A comprehensive literature search was performed relating to oral minoxidil role in various alopecia. Various clinical trials, case series, and case reports were searched on PubMed and Google Scholar. The references of available studies were also reviewed to collect the additional resources. Available data from various studies and case reports were collected and consolidated to provide a concise overview of oral minoxidil indications in various alopecia. Results:Oral minoxidil has been used in various non-scarring and scarring alopecia at a lower dosage with less side effects and with promising results. Androgenetic alopecia and female pattern hair loss were the two conditions where it has been used more commonly than other alopecia, providing a ray of hope along with overcoming the issues related to topical formulations and compliance.

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Oral minoxidil use in androgenetic alopecia and telogen effluvium

Cited by 6 publications

References 13 publications

Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

Role of oral minoxidil in patterned hair loss

Comprehensive review of oral minoxidil in alopecia

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