Oral Minoxidil: A Possible New Therapy for Androgenetic Alopecia

Gomolin, Arieh; Litvinov, Ivan V.; Netchiporouk, Elena

doi:10.1177/1203475419879887

Cited by 12 publications

(19 citation statements)

References 5 publications

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“…The adverse events most frequently reported are hypertrichosis, tachycardia and fluid retention, in most cases not severe enough for patients to suspend treatment 5 . Contraindications are limited, including drug hypersensitivity and history of pheochromocytoma 26 . Since minoxidil is renally cleared, patients with renal failure or dialysis may require smaller doses, but those with severe hepatic impairment should be monitored closely as well 3 .…”

Section: Discussionmentioning

confidence: 99%

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Villani

Fabbrocini

Candiani³

et al. 2021

Acad Dermatol Venereol

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Topical minoxidil has been used for many years as treatment for different hair disorders. Even though it is an effective therapy, many patients show poor compliance due to the cosmesis, cost and side‐effects. During the last few years, low‐dose oral minoxidil has proven to be an alternative for patients with alopecia. We performed a literature search including all the articles that used oral minoxidil as a primary treatment in various hair diseases in order to evaluate the efficacy and safety of low‐dose oral minoxidil as an alternative to topical minoxidil. Androgenetic alopecia was the most common studied condition, but others included telogen effluvium, tractional alopecia, postchemotherapy‐induced alopecia, monilethrix, loose anagen hair syndrome, alopecia areata and scarring alopecias (frontal fibrosing alopecia and lichen planopilaris). Larger randomized comparative studies including standardized objective measurements should be done in order to clarify the best treatment protocol, including dosage and treatment duration. Oral minoxidil has proven to be a successful and well‐tolerated alternative for patients with hair loss, including those with poor adherence to other therapies. Different dosing regimens have been utilized in scarring and non‐scarring alopecia, varying from 0.25 to 5 mg daily. Higher doses have not been studied in men or women. Available literature suggests women require lower doses, from 0.25 to 2.5 mg daily, while men require higher doses for maximal efficacy, from 1.25 to 5 mg a day.

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Section: Discussionmentioning

confidence: 99%

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Villani

Fabbrocini

Candiani³

et al. 2021

Acad Dermatol Venereol

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“…[5,15] Nevertheless, several studies have been conducted all over the world with various doses for treatment of alopecia and an increasing number of data show that OM can be considered as a possible therapeutic option for AGA. [2,[16][17][18][19][20] Due to its side effect profile, recently many authors have propounded a low dose OM regimen for treating AGA. In patients not responding to or are resistant to conventional therapy the search for other treatment avenues has been discouraging.…”

Section: Efficacymentioning

confidence: 99%

“…[25,[27][28][29][38][39][40][41]45,47] Contraindications to OM include pheochromocytoma or previous hypersensitivity reactions to ingredients, hypotension, cardiac comorbidities, and pregnancy or breast feeding. [20] Considered as Pregnancy Category-C drug, rare reports of fetal malformations have been reported. [36] Use of OM has also been studied in pediatric patients in a review article by Lemes et al where they concluded that data for use in hair growth was insufficient and that adverse effects were a cause of concern in this age group.…”

Section: A=47 B=48mentioning

confidence: 99%

Role of low dose oral minoxidil in the treatment of hair loss: A review

Alexander

Mysore²,

Hirevenkangoudar

2021

CSDM

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Low-dose oral minoxidil (OM) has increasingly been used by many doctors around the world as a treatment option for hair loss. Sufficient data regarding its effect and side effect profile are lacking. An online search was done on PUBMED and GOOGLE SCHOLAR for articles that used OM as a treatment option for hair loss. Doses ranging from 0.25 to 5 mg have been used for treatment in various studies. Good compliance and tolerability have been noticed with low-dose OM therapy. Adverse effects are few and are mild with hypertrichosis being the most common adverse effect in a majority of the studies, the risk of which increases with an increase in dosage of the drug.

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“…Oral minoxidil (OM) has been reported to be effective for FPHL alone or in combination with other therapies and in doses ranging from 0.25 to 2.5 mg/d 3 . Some of the reported adverse effects of such doses of OM include lower limb edema, generalized hypertrichosis, hair loss, urticaria and other allergic reactions 1‐4 . In this retrospective study, we share our experience of using OM for >6 months in 12 patients with female androgenetic alopecia (AGA) (Ludwig scale I‐3‐III).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of oral minoxidil in female androgenetic alopecia

Vastarella

Cantelli

Patrì

et al. 2020

Dermatologic Therapy

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Oral minoxidil (OM) has been reported to be effective for androgenetic alopecia (AGA). In this retrospective study, we share our experience of using OM for >24 weeks in 12 patients with female AGA (Ludwig scale I-3-III). Twelve women (aged 18-66 years; mean age 36.66 ± 18.79 years) with AGA (Ludwig scale I-3-III) were recruited. The starting dose of minoxidil was 0.50 mg daily; at 3 months, the dose was increased to 1.50 to 2 mg daily. Efficacy outcome measures were evaluated at baseline and after 24 weeks and included global clinical photography, quantitative digital videotrichoscopic assessment and quality-of-life evaluation. An overall improvement of 38% and 23% in hair density in the frontal and vertex area, respectively, was observed after 24 weeks. The quantitative digital videotrichoscopic evaluation highlighted a statistically significant improvement in the frontal area of the total average hair density and of the total number of hairs per unit area at 24 weeks

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Oral Minoxidil: A Possible New Therapy for Androgenetic Alopecia

Cited by 12 publications

References 5 publications

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Role of low dose oral minoxidil in the treatment of hair loss: A review

Efficacy and safety of oral minoxidil in female androgenetic alopecia

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