Oral Microbiome in Patients with Oesophageal Squamous Cell Carcinoma

Wang, Qian; Rao, Yuting; Guo, Xia; Liu, Na; Liu, Shuxiu; Wen, Peipei; Li, Shuang; Li, Yuan

doi:10.1038/s41598-019-55667-w

Cited by 50 publications

(49 citation statements)

References 29 publications

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“…In about 23% of patients, who underwent surgical resection of esophageal cancer, F. nucleatum was detected in cancer tissues. The presence of these bacteria in cancer tissue was also associated with a significantly shorter survival time [414].…”

Section: Cancers Of Digestive Systemmentioning

confidence: 97%

Human Gut Microbiota: Friend or Foe?

Pliszka¹,

Szablewski²

2020

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The human gut is a house to approximately 1,000 different species of bacteria. The bacterial composition of gut microbiota is influenced by several factors, including age, sex, mode of delivery, geographical location, ethnicity, diet, drugs, and administration of prebiotics and/or probiotics. Similarly, human health depends on the composition of gut microbiome, with gut bacteria playing a crucial role in human physiology. For instance, gut microbiota synthesizes vitamins and amino acids, and affects the biotransformation of bile acid. Intestinal microbiota produces short-chain fatty acids (SCFAs) that stimulate intestinal gluconeogenesis, protect the host from diet-induced obesity, and may play a role as an energy substrate. Changes in the composition of gut microbiota, termed dysbiosis, due to, for example, change in the diet or uptake of certain drugs, may result in metabolic diseases, autoimmune and allergic diseases, cancers, and many others. Conversely, dysbiosis can be a consequence of a disease in several cases. This review outlines the current knowledge of the associations between human gut microbiota and human health and diseases.

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Section: Cancers Of Digestive Systemmentioning

confidence: 97%

Human Gut Microbiota: Friend or Foe?

Pliszka¹,

Szablewski²

2020

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“…Other risk factors, such as poor oral health, have been linked to esophageal squamous dysplasia, a precursor for ESCC[ 117 ]. Exposure to various environmental triggers may directly stimulate epithelial expression of inflammatory markers, or may indirectly lead to proinflammatory state through changes in the microbiome[ 118 ].…”

Section: Dysbiosis In Disease Statesmentioning

confidence: 99%

“…[ 118 ]. Generally, there is also a decrease in bacterial diversity, and increase in interpersonal compositional variation, suggestive that the dysbiotic state is not stable[ 118 , 119 ]. As with EAC, there is a close association with oral cavity disease/dysbiosis and ESCC.…”

Section: Dysbiosis In Disease Statesmentioning

confidence: 99%

Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease: A paradigm shift from acid to bacteria?

D’Souza¹,

Houston²,

Keenan³

et al. 2021

WJG

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Genomic sequencing, bioinformatics, and initial speciation ( e.g. , relative abundance) of the commensal microbiome have revolutionized the way we think about the “human” body in health and disease. The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases, including those impacting the esophagus. Although relatively stable, there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome (EM) and the host. These changes are thought to be a product of age, diet, antibiotic and other medication use, oral hygiene, smoking, and/or expression of antibiotic products (bacteriocins) by other flora. These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation, systemic inflammation, and ultimately disease progression. Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is, therefore, not merely the result of esophageal mucosal exposure to corrosives ( i.e. , acid). Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade. Here, we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief ( i.e. , acid suppression).

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“…As part of the tumor microenvironment, microorganisms may participate in tumor development by inducing chronic or persistent inflammation [6]. However, the microecological composition of each part is not uniform, and different parts of the gastrointestinal tract may have specific microecological communities [7].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on the Esophageal Microflora of Different Tissue Types in Patients With Esophageal Squamous Cell Carcinoma

Liu¹,

Gao²,

Xu³

et al. 2021

Preprint

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Objective: This study aimed to compare the differences in microbiota between the postoperative tissues and esophageal mucosa tissues of patients with esophageal squamous cell carcinoma (ESCC). Methods: Seventy-two patients who had ESCC and diagnosed in Taihe Hospital were selected from July 2018 to July 2019 to participate in this work. Then, 27 postoperative tissues and 45 mucosa samples of ESCC were collected. The sequence V4 hypervariable region was amplified, and Illumina MiSeq sequencing was performed to analyze the differences between the two groups. Results: Results revealed that the Shannon and Chao1 indices of the postoperative esophageal cancer tissue group (Group A) were significantly higher (P<0.05) than those of the esophageal mucosa group (Group B). The Simpson index of Group A was higher than that of Group B, but the difference was not significant (P>0.05). The beta diversity of the two groups was also not significantly different (P>0.05). LEfSe analysis showed that the abundance of Megasphaera, Actinobacteria, Enterobacteriaceae, and Enterobacteriales in Group A was significantly higher than that in Group B, but the abundance of Mogibacteriaceae in Group B was significantly higher than that in Group A (P<0.05). At the phylum level, Actinobacteria and Verrucomicrobiae were more abundant in the postoperative tissue group than in the esophageal mucosa group. The abundance of Fusobacteriia, SR1, and Spirochaetes in the postoperative tissue group was significantly lower than that of the esophageal mucosa group(P<0.05). Conclusion: The source of the sample should be considered in studies on the esophageal flora. More relevant findings were obtained from postoperative tissues than from the normal mucosa.

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Oral Microbiome in Patients with Oesophageal Squamous Cell Carcinoma

Cited by 50 publications

References 29 publications

Human Gut Microbiota: Friend or Foe?

Human Gut Microbiota: Friend or Foe?

Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease: A paradigm shift from acid to bacteria?

Comparative Study on the Esophageal Microflora of Different Tissue Types in Patients With Esophageal Squamous Cell Carcinoma

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