Oral Metronomic Vinorelbine in Advanced Non-small Cell Lung Cancer Patients Unfit for Chemotherapy

Abstract

These data support the activity and safety of metronomic vinorelbine in a relevant proportion of patients usually excluded from any specific treatment.

Deep LSTM with Dynamic Time Warping Processing Framework: A Novel Advanced Algorithm with Biosensor System for an Efficient Car-Driver Recognition

“…Both heart pulse and respiratory rate of a subject can be monitored by means of ad hoc analysis of such PPG signal features [11]. Through the PPG signal, a non-invasive measurement of the blood volume dynamic can be done for several medical assessments [13,14]. A standard PPG waveform includes a pulsatile ("AC") physiological waveform which is correlated to cardiac-synchronous changes in the blood volume superimposed with a slowly varying ("DC") component containing lower frequency information correlated to respiration, thermoregulation, and skin tissues (in which the PPG sensor is adapted) [11].…”

“…In this setup, in the driving range 0-3 V, the device had a maximum photon detection efficiency (PDE) of approximately 29.4% The implemented sensing device was comprised of the following two main components: a silicon photomultipliers (SiPMs) detector and two LED photon emitters. The SiPM detector used in our system was produced by STMicroelectronics (Catania, Italy) [11][12][13][14][15] and featured a total area of 4.0 × 4.5 mm 2 and 4871 square microcells with 60 µm of pitch. It had a geometrical fill factor of 67.4% and was packaged in a surface mount housing (SMD) of 5.1 × 5.1 mm 2 total area [15][16][17].…”

“…Furthermore, a dichroic filter for reducing the absorption of environmental light by more than 60% in the linear operation range was included. As emitter, we proposed the use of two LT M673 LEDs (OSRAM, Milan, Italy) based on InGaN technology (in SMD package) emitting at 873 nm and used as optical light sources [11][12][13][14][15][16][17]. The LEDs had an area of 2.3 × 1.5 mm 2 , a viewing angle of 120 • , and typical power emission of a few mW in the standard operation range [15][16][17].…”

“…There are more details provided in [11][12][13][14][15][16][17][18]. at 565 nm and approximately 27.4% at 540 nm (central wavelength in the filter pass band).…”

“…The LEDs had an area of 2.3 × 1.5 mm 2 , a viewing angle of 120°, and typical power emission of a few mW in the standard operation range [15][16][17]. There are more details provided in [11][12][13][14][15][16][17][18]. Figure 3 depicts some electrical features of the proposed SiPM detector.…”