Oral metronidazole treatment of lichen planus

Büyük, Arzu; Kavala, Mukaddes

doi:10.1067/mjd.2000.104683

Cited by 46 publications

(17 citation statements)

References 12 publications

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“…12 Narrowband UVB therapy has also been reported to be effective, showing complete clearance in all five patients in one open-labelled study. 16 Other therapies that have been found to be useful include cyclosporin, griseofulvin, azathioprine, mycophenolate, levamisole and dapsone. 13,14 A retrospective study, comparing PUVA and narrowband UVB therapy, showed comparable results, although PUVA produced better initial clinical response rate.…”

Section: Discussionmentioning

confidence: 99%

Pulsed itraconazole therapy in eruptive lichen planus

Khandpur

Sugandhan

Sharma

2008

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 99%

Pulsed itraconazole therapy in eruptive lichen planus

Khandpur

Sugandhan

Sharma

2008

Acad Dermatol Venereol

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“…In einer türkischen Untersuchung aus dem Jahre 2000 [55] mit 19 Patienten wurde Metronidazol in einer Dosis von 2-mal 500 mg/Tag über 20-60 Tage verordnet. In der Nachbeobachtungszeit, die bei den meisten Patienten mehr als 20 Monate betrug, zeigte sich eine komplette Remission in 13 Fällen und eine Teilremission in 2 Fällen.…”

Section: Idiopathischer Lichen Ruber Planusunclassified

“…Andererseits werden jedoch neben den Tetracyclinen gerade die Makrolide als Prototypen für immunmodulatorisch wirksame Antibiotika angesehen [6,7,8].Von manchen Autoren, wie z. B. in der Studie zur Metronidazol-Therapie bei Lichen planus [55], wird deshalb ein weitestgehender Fokusausschluss betont, wodurch für den primären Wirkmechanismus des Antibiotikums nichtmikrobizide Effekte wahrscheinlicher werden. Diese These wird auch durch die Krankheitsverläufe zahlreicher Patienten unterstützt, bei denen Rezidive nach Absetzen des Antibiotikums auftraten und wiederholte Behandlungserfolge durch erneute Einnahme erzielt werden konnten.…”

Section: Studien Zu Oralen Antibiotika Mit Möglicher Immunmodulatorisunclassified

Orale Antibiotika mit antiinflammatorischer/immunmodulatorischer Wirkung für die Therapie verschiedener Dermatosen

Brinkmeier

Frosch

2002

Hautarzt

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A range of antibiotics has been shown to modify host functions apart from the antimicrobial potency. They may directly influence phagocyte and lymphocyte function, as well as chemotaxis. Effects on the generation and release of various cytokines involved in the inflammatory process have been studied both in vivo and in vitro. However, the molecular mechanisms have not been elucidated in detail. It is suggested that antibiotics can exert immunopharmacological effects on the basis of structure-activity relationships independent of their antibacterial activity. We present a collection of clinical studies and case reports dealing with the potential benefits of systemic antibiotics in the treatment of selected dermatoses which have primarily been classified as non-infectious. Generally accepted treatments such as dapsone in dermatitis herpetiformis and leukocytoclastic vasculitis or chloroquine in lupus erythematosus have not been considered. Based on existing clinical trials with a higher number of cases the following antibiotics have been shown to be effective: erythromycin in bullous pemphigoid and pityriasis rosea as well as tetracyclines in pemphigus vulgaris, bullous pemphigoid and pustulosis palmaris et plantaris. However, most reports have to be viewed critically due to the uncontrolled study design, particularly in dermatoses with a tendency to spontaneous resolution. Despite this lack of evidence-based data, it is important for the clinician to know about the potential use of antibiotics for various skin disorders as a primary treatment option or steroid-sparing therapeutic adjunct. In clinical practice the use of antibiotics depends on various factors including the severity of the disease, the patient's age, contraindications to conventional therapeutic regiments and economic considerations.

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“…The metronidazole has a good safety profile, low cost, and has been recommended (level C of recommendation) for LP therapy (in VVGS-LP, no studies or case reports have been cited in the medical literature) [21]. It is probable that metronidazole acts as an immunomodulator, decreasing the activity of inflammatory diseases [12].…”

Section: Treatmentmentioning

confidence: 99%

“…There are some diseases which can contribute to the maintenance of LP, such as: HCV, diabetes, anxiety and stress management, and hypertension. Treating oral lesions, also, is often difficult because of tongue movements and salivary flow which easily clear drugs [21]. Conventional treatment of OLP is based on the application of corticosteroids as a basic A Review of Vulvovaginal-Gingival Syndrome.…”

Section: Treatmentmentioning

confidence: 99%

A Review of Vulvovaginal-Gingival Syndrome. Case Report

Grau¹,

Roig²,

Juncadella³

et al. 2017

UCMS

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Abstract:Vulvovaginal-gingival syndrome (VVGS) is a chronic mucocutaneous disease of unknown etiology, which consists of a triad of symptoms: vulvar, vaginal and gingival of lichen planus (LP) lesions. The evidence suggests an autoimmune response, a genetic and probably hormonal component. Associated factors observed in LP include stress/anxiety, hepatitis C virus (HCV) and autoimmune diseases, among others. The most serious complication of oral and possibly also vulvar Lichen Planus is the development of squamous cell carcinoma. Corticosteroids are the mainstay treatment for LP in order to control inflammatory activity. In case of failure, immunosuppressive agents can be used (Tacrolimus and Cyclosporine). We present an illustrated case of VVGS who over the years developed tongue cancer and, 10 years later, a vulvar cancer. Oral Lichen Planus (OLP) should be referred to the appropriate specialists to rule out involvement of other mucous membranes and track it early to diagnose a possible malignant transformation. The efficient management of VVGS involves a multidisciplinary approach involving gynecologists, dermatologists and stomatologists.

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Oral metronidazole treatment of lichen planus

Cited by 46 publications

References 12 publications

Pulsed itraconazole therapy in eruptive lichen planus

Pulsed itraconazole therapy in eruptive lichen planus

Orale Antibiotika mit antiinflammatorischer/immunmodulatorischer Wirkung für die Therapie verschiedener Dermatosen

A Review of Vulvovaginal-Gingival Syndrome. Case Report

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