Oral manifestations of vitamin D deficiency in children

Fulton, Andrew; Amlani, Maya; Parekh, Susan

doi:10.1038/s41415-020-1424-y

Cited by 6 publications

(12 citation statements)

References 30 publications

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“…Although the underlying mechanisms are not clear, disturbances in calcium homeostasis and vitamin D deficiencies that can occur in NS 2 , in particular during dental development, have been associated with the development of EH 6 . A correlation between an early age of onset of the NS and the prevalence of CEH has been reported 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Chronological enamel hypoplasia (CEH) is a developmental defect that presents with distinct characteristic banding around the crowns of teeth. The location of the defective enamel is a permanent chronological record of past disturbances, corresponding with the age of disease onset 6 . Enamel hypoplasia (EH) is a well-known phenomenon in children with chronic renal failure (CRF) 7 .…”

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confidence: 99%

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Congenital nephrotic syndrome: Oral manifestations and dental implications

Wan

Widmer

Prabhu

2022

Journal of Clinical Pediatric Dentistry

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Children with congenital nephrotic syndrome (CNS) can present with oro-dental complications secondary to the disease or from the treatment of the condition. This case report describes the multidisciplinary management of a 12-year-old male patient with CNS. It highlights the importance for pediatricians and nephrologists to be aware of the dentists’ role in the general health and well-being of children with chronic renal disease.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Congenital nephrotic syndrome: Oral manifestations and dental implications

Wan

Widmer

Prabhu

2022

Journal of Clinical Pediatric Dentistry

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“…This allows a mapping chronological timeframe (Figure 2) and a classification by putative biological mechanisms (Figure 3). Some factors are well-reported and have been the subject of review papers (not analyzed in this SC): severe respiratory distress syndromes (146), preterm birth (147), vitamin D deficiencies during childhood (148), cleft palate (149), syphilis (150), excess fluoride (151), renal disorders (133), diabetes type 1 (152), cancer therapy (153), organic pollutants (154), dioxin exposure (155), dietary components (156), drugs during pregnancy and the first year of life (157), and drugs during infancy (158); these do not always relay clear evidence between DDE and risk factors supporting our hypothesis of accumulation and synergy effects. Generalist reviews were found, but either did not identify as many factors in a systematic way (159), or focused on one type of DDE (160), dentition (161) or treatment (162).…”

Section: Highlight the Current Literature And Better Understand The N...mentioning

confidence: 99%

Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review

et al. 2022

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BackgroundDevelopmental Defects of Enamel (DDE) is a pathology of the teeth that can greatly alter the quality of life of patients (hypersensitivity, esthetic issues, loss of function, etc.). The acquired DDE may occur as a result of a wide range of acquired etiological factors and his prevalence of this pathology may reach up to 89.9%. The main objective of this research was to identify and analyze, in current literature, the factors related to acquired DDE, in order to propose a general theory about the mechanisms involved.MethodsThe search of the primary literature was conducted until [December 31, 2021]. Our search strategy uses the Pubmed/MEDLINE database and was structured around 3 terms [“Development,” “Defect,” and “Enamel”]. To be included, references had to be primary studies, written in English. Exclusion criteria were reviews, in vitro, animal, genetic or archeology studies, and studies focused on clinical management of DDE. One hundred and twenty three articles were included in this scoping review: 4 Randomized clinical trials, 1 letter, 5 cases reports, 2 fundamentals studies, and 111 observational studies (33 Cross-sectional studies, 68 Cohort study and 10 Case-control study). The quality of evidence was assessed using the PEDro scale for clinical trials, the Newcastle-Ottawa scale for observational studies, and a published tool to assess the quality of case reports and case series.ResultsA scoping review of the literature identified 114 factors potentially involved in acquired DDE. The most frequently encountered pathologies are those causing a disorder of calcium homeostasis or a perturbation of the ARNT pathway in mother or child. The link between the ARNT pathway and metabolism deficiency in uncertain and needs to be defined. Also, the implication of this mechanism in tissue impairment is still unclear and needs to be explored.ConclusionsBy identifying and grouping the risk factors cited in the literature, this taxonomy and the hypotheses related to the mechanism allow health practitioners to adopt behaviors that limit the risk of developing aDDE and to set up a prevention of dental pathology. In addition, by reviewing the current literature, this work provides guidance for basic research, clinical studies, and literature searches.

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“…Including the process of tooth development known as odontogenesis [3] . Adequate levels are considered above 50 nmol/L, with deficiency defined as below 25 nmol/L [4] .…”

Section: Introductionmentioning

confidence: 99%

“…In children, the deficiency can lead to rickets, a condition marked by poor bone mineralization, while adults may experience osteomalacia. Additionally, maternal Vitamin D levels are crucial for prenatal health, influencing the risk of several conditions including gestational diabetes and low birth weight [4] .…”

Section: Introductionmentioning

confidence: 99%

The effect of Vitamin D deficiency on the occurrence of enamel hypoplasia in babies: A review article

Salma Putri Widyanti,

Emmanuel Andrew,

Tantiana

2024

World J. Adv. Res. Rev.

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Background: Vitamin D is a steroid prohormone that can be obtained primarily from exposure to sunlight and can also be obtained from food or supplements. Vitamin D has an important role in various metabolisms and developments in the human body, including in the process of odontogenesis or tooth development. Vitamin D deficiency can be associated with various problems in the oral cavity, in this case it has the potential to trigger enamel hypoplasia. Enamel hypoplasia is a quantitative defect in enamel, which appears as pits, grooves, missing enamel or smaller teeth. This literature study will discuss the relationship between Vitamin D concentration and dental development in early childhood. Method: The method used is an article review that was conducted by analyzing various articles on related themes on virtual platforms such as PubMed, Google Scholar, ProQuest, and Science Direct. Results: Vitamin D significantly affects the development of teeth in fetuses to babies. Conclusion: Vitamin D plays an important role in various metabolisms and development of the human body. Vitamin D deficiency can cause developmental disorders and various diseases of the oral cavity such as enamel hypoplasia.

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Oral manifestations of vitamin D deficiency in children

Cited by 6 publications

References 30 publications

Congenital nephrotic syndrome: Oral manifestations and dental implications

Congenital nephrotic syndrome: Oral manifestations and dental implications

Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review

The effect of Vitamin D deficiency on the occurrence of enamel hypoplasia in babies: A review article

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