Oral manifestations of systemic disease

Porter, Stephen; Mercadente, V.; Fedele, Stefano

doi:10.1038/bdjteam.2018.12

Cited by 8 publications

(6 citation statements)

References 64 publications

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“…A number of hematological malignancies including acute leukemia have manifestations in the oral cavity (Porter, Mercadente, & Fedele, 2018). In a previous retrospective study, the most common oral manifestations of leukemia reported included gingival bleeding (43.2% in AML; 28.6% in ALL), followed by oral ulceration and gingival enlargement (Hou, Huang, & Tsai, 1997).…”

Section: Discussionmentioning

confidence: 99%

Prospective evaluation of clinical symptoms of chemotherapy‐induced oral mucositis in adult patients with acute leukemia: A preliminary study

Lee

Hong

Kim

et al. 2019

Clinical & Exp Dental Res

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Objective The objective of this study was to prospectively evaluate the clinical features of chemotherapy‐induced oral mucositis (CIOM) in adult patients with acute leukemia and the aggravating factors for such symptoms. Subjects Thirty‐seven prospective patients aged ≥19 years with acute leukemia undergoing chemotherapy were enrolled. Oral and clinical investigations were performed at baseline and on Day 14 after starting chemotherapy. The presence and severity of cancer‐induced oral mucositis were demonstrated using the World Health Organization (WHO) scoring system. Results On Day 14, we found that oral mucositis had developed in eight patients (21.6%). Hematopoietic stem cell transplantation (HSCT) in patients was a predictor of increased WHO scores (β = 1.937, p < .001). Regarding oral sites, ventral tongue (β = 1.670), soft palate (β = 1.242), and buccal mucosa (β = 0.593) were predictors for increased scores. In addition, the increase in WHO scores was positively correlated with the number of oral lesions (r = .521), the difficulty in eating (r = .250), and the overall oral health (r = .534; all p < .05). Conclusion The main factors affecting the severity of CIOM symptoms were the treatment with HSCT and the location of oral lesions. The incidence of CIOM and WHO scores were not significantly different between the subgroups of disease. Our findings will help clinicians investigate the oral findings after chemotherapy in adult patients with acute leukemia.

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Section: Discussionmentioning

confidence: 99%

Prospective evaluation of clinical symptoms of chemotherapy‐induced oral mucositis in adult patients with acute leukemia: A preliminary study

Lee

Hong

Kim

et al. 2019

Clinical & Exp Dental Res

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“…Interest in the link between oral and general health manifests not only in epidemiological studies, but also in the potential of the oral mucosa and saliva for diagnosis of systemic diseases [ 152 , 153 ]. A wide variety of systemic diseases have a direct effect in the oral mucosa, including viral infections, dermatoses, hematologic disorders, endocrine diseases, gastrointestinal disorders, malignancy, and autoimmune diseases, among others [ 123 , 131 , 136 , 154 , 155 , 156 ]. Ulceration, white patches, swellings, pigmentation changes, or periodontal inflammation are the main lesions found in the oral mucosa of systemic disease patients [ 135 , 139 , 143 , 154 ].…”

Section: Oral Mucosa In Other Allergies and Inflammatory Pathologiesmentioning

confidence: 99%

“…A wide variety of systemic diseases have a direct effect in the oral mucosa, including viral infections, dermatoses, hematologic disorders, endocrine diseases, gastrointestinal disorders, malignancy, and autoimmune diseases, among others [ 123 , 131 , 136 , 154 , 155 , 156 ]. Ulceration, white patches, swellings, pigmentation changes, or periodontal inflammation are the main lesions found in the oral mucosa of systemic disease patients [ 135 , 139 , 143 , 154 ]. Although an association is obvious, whether alterations in the oral mucosa are solely a clinical manifestation of the systemic disease or whether they actively contribute to their development has not been clearly established for many diseases [ 144 , 147 , 156 , 157 ].…”

Section: Oral Mucosa In Other Allergies and Inflammatory Pathologiesmentioning

confidence: 99%

Oral Mucosa as a Potential Site for Diagnosis and Treatment of Allergic and Autoimmune Diseases

Gómez‐Casado

Sánchez-Solares

Izquierdo

et al. 2021

Foods

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Most prevalent food allergies during early childhood are caused by foods with a high allergenic protein content, such as milk, egg, nuts, or fish. In older subjects, some respiratory allergies progressively lead to food-induced allergic reactions, which can be severe, such as urticaria or asthma. Oral mucosa remodeling has been recently proven to be a feature of severe allergic phenotypes and autoimmune diseases. This remodeling process includes epithelial barrier disruption and the release of inflammatory signals. Although little is known about the immune processes taking place in the oral mucosa, there are a few reports describing the oral mucosa-associated immune system. In this review, we will provide an overview of the recent knowledge about the role of the oral mucosa in food-induced allergic reactions, as well as in severe respiratory allergies or food-induced autoimmune diseases, such as celiac disease.

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“…There are variations in the presentation and frequency of oral manifestation of systemic diseases. The number of people with oral manifestations of systemic diseases has been estimated to increase (4). Elderly are likely to have various manifestations associated with systemic diseases, that could affect the oral health care (5).…”

Section: Introductionmentioning

confidence: 99%

The Prevalence and Correlates of Fissured Tongue Among Outpatients in A Regional Area of Afghanistan

Hamrah¹,

Baghalian²,

Ghadimi³

et al. 2021

Preprint

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Background: Fissured tongue is a common manifestation of the tongue, marked by the presence of multiple prominent grooves or fissures on the dorsal surface of the tongue. However, there is a lack of studies focusing on the prevalence and factors associated with fissured tongue among patients attending an outpatient clinic living in regional areas of Afghanistan. Aims: The purpose of the current study was to determine the prevalence and factors associated with fissured tongue among adult outpatients in Afghanistan in regional areas of Afghanistan. Methods: The cross-sectional survey was conducted among outpatient populations in Andkhoy, Afghanistan, between September 2019 and December 2019. Socio-economic status, smoking, nass use (smokeless tobacco use) and medical data were also assessed. We used the logistic regression models to identify factors associated with fissured tongue. Results: The studied population consisted of 1182 participants, of whom 573 (48.5%) were male and 609 (51.5%) female. The prevalence of fissured tongue was 27.2% (95% CI: 24.7-29.9%) with male having significantly higher prevalence than female (47.5%, 95% CI: 43.3-51.6% versus 8.2%, 95% CI: 6.2-10.7%, p<0.001). Male participants (OR=7.1, 95% CI: 4.8-10.3), Diabetes mellitus (OR 1.6, 95% CI: 1.1-2.3) and smokeless tobacco use (OR, 12.0 95% CI: 8.1-17.6) were the only variables independently associated with fissured tongue. Conclusions: This study suggested that there was a high rate of fissured tongue among an outpatient clinic in Andkhoy, Afghanistan. Male gender, diabetes mellitus, and nass consumption were associated with fissured tongue. Therefore, these factors might usefully be targeted in local health promotion, prevention and early intervention programs.

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Oral manifestations of systemic disease

Cited by 8 publications

References 64 publications

Prospective evaluation of clinical symptoms of chemotherapy‐induced oral mucositis in adult patients with acute leukemia: A preliminary study

Prospective evaluation of clinical symptoms of chemotherapy‐induced oral mucositis in adult patients with acute leukemia: A preliminary study

Oral Mucosa as a Potential Site for Diagnosis and Treatment of Allergic and Autoimmune Diseases

The Prevalence and Correlates of Fissured Tongue Among Outpatients in A Regional Area of Afghanistan

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