Oral manifestations of Langerhans cell histiocytosis with unusual histomorphologic features

AbdullGaffar, Badr; Awadhi, Farzad

doi:10.1016/j.anndiagpath.2020.151536

Cited by 7 publications

(8 citation statements)

References 13 publications

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“…The differential diagnosis depends on the site of involvement. Oral involvement may histologically be confused with granulomas, allergic-like inflammation, stomatitis, cysts, foreign-body giant cell reaction, lymphoma, and metastasis [ 4 ]. Cyclin D1 is an efficient marker to differentiate neoplastic from reactive LC proliferation [ 5 ].…”

Section: To the Editormentioning

confidence: 99%

A Rare Case of Langerhans Cell Histiocytosis in the Hard Palate

Atay¹,

Gün²

2022

Tjh

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Section: To the Editormentioning

confidence: 99%

A Rare Case of Langerhans Cell Histiocytosis in the Hard Palate

Atay¹,

Gün²

2022

Tjh

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“…However, the tip for a correct diagnosis is the coffee bean or kidney-shaped indentations in the nucleus of the histiocytes. 31 A histologic aspect resembling epithelioid granulomas may be found in some atypical cases, possibly simulating early juvenile xanthogranulomas. 10 Some microscopic aspects of LCH are shown in Figure 3.…”

Section: Microscopy Findingsmentioning

confidence: 99%

“…The presence of necrosis can mimic other infectious and neoplastic conditions such as tuberculosis and Hodgkin's lymphoma. However, the tip for a correct diagnosis is the coffee bean or kidney‐shaped indentations in the nucleus of the histiocytes 31 . A histologic aspect resembling epithelioid granulomas may be found in some atypical cases, possibly simulating early juvenile xanthogranulomas 10 .…”

Section: Overviewmentioning

confidence: 99%

Langerhans cell histiocytosis in the oral and maxillofacial region: An update

Faustino

Fernandes

Pontes

et al. 2021

J Oral Pathology Medicine

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Langerhans cells (LC) are a group of antigen-presenting, migratory and non-proliferative cells belonging to a group of leukocytes called dendritic cells (DC). In normal scenarios, LC is found in the suprabasal layer of the epidermis and in bronchial, urogenital, and oropharyngeal mucosas. 1 Langerhans cell histiocytosis (LCH) is a condition characterized by abnormal proliferation and infiltration of marrow-derived LC that may be diagnosed in oral and maxillofacial tissues. 2,3 Therefore, the aim of the present report was to describe the main characteristics of this uncommon disease, with emphasis on its clinical manifestations, microscopic features, and the therapeutic approaches currently available. This study forms part of a special issue published by the Journal of Oral Pathology and Medicine covering the most important aspects of hematolymphoid lesions and neoplasms affecting the oral cavity and neighboring structures. | OVERVIE WThe first case of LCH was described by Hand in 1893. 4 More than hundred years later, LCH still challenges physicians from the diagnosis to treatment due to reasons such as the rare occurrence of this condition and its broad clinical manifestations. 5 Following the first description, LCH was called as monocyte-macrophage system disease because of the identification of histiocyte-like cells in affected tissues. In this respect, Hand-Schuller-Christian syndrome, Letterer-Siwe disease,

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“…Langerhans cell histiocytosis (LCH) is thought to be a proliferative disorder of bone marrowderived immature cells, presenting with diverse clinical manifestations, that commonly affect skeletal bones, skin, lymph nodes, and lungs. [1] Serum soluble interleukin-2 receptor (sIL-2r) level has been proposed as a prognostic factor or indicator of disease activity. [14,15] However, the mechanism underlying LCH development is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Calvarial Langerhans cell histiocytosis in an adult presenting rapid growth

Sugiyama

Tsutsumi

Hashizume

et al. 2022

Surgical Neurology International

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Background: Langerhans cell histiocytosis (LCH) arising in the skull is rare in adulthood. Case Description: A 58-year-old woman experienced a durable headache. Cerebral magnetic resonance imaging (MRI) at presentation showed no abnormalities; however, MRI and computed tomography (CT) performed 6 weeks later revealed the emergence of a well-demarcated, heterogeneously enhancing calvarial tumor accompanied by irregular-shaped bone erosion. On MRI, the temporalis muscle and subcutaneous tissue adjacent to the tumor were extensively swollen and enhanced. The patient underwent en bloc resection. The microscopic appearance of the tumor was consistent with that of LCH. Postoperative systemic 18F-fluorodeoxyglucose positron emission tomography/CT did not detect any abnormal accumulation. Conclusion: LCH may develop within a short period. It should be considered as a differential diagnosis when a rapidly growing calvarial tumor is encountered, even when the patient is an adult. Prompt histological verification is recommended in such cases.

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Oral manifestations of Langerhans cell histiocytosis with unusual histomorphologic features

Cited by 7 publications

References 13 publications

A Rare Case of Langerhans Cell Histiocytosis in the Hard Palate

A Rare Case of Langerhans Cell Histiocytosis in the Hard Palate

Langerhans cell histiocytosis in the oral and maxillofacial region: An update

Calvarial Langerhans cell histiocytosis in an adult presenting rapid growth

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