Oral manifestations of Crohn's disease.

Asquith, P.; Thompson, Rachel; Cooke, W. T.

doi:10.1136/gut.16.4.249

Cited by 111 publications

(26 citation statements)

References 27 publications

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“…Iron deficiency leads to angular stomatitis and painful depapillation of the tongue. 11,23 In patient 2, who was diagnosed with CD, the constant vitamin and nutritional deficiencies, especially in iron and zinc, may have a strong correlation with angular cheilitis and erosive and crusty lesions on the lip commissures and perioral region.…”

Section: Discussionmentioning

confidence: 99%

Oral Manifestations of Inflammatory Bowel Diseases: Two Case Reports

Pereira

Munerato

2016

Clinical Medicine & Research

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Inflammatory bowel diseases (IBD) are known as chronic inflammatory disorders of the digestive tract, represented mainly by Crohn's disease (CD) and ulcerative colitis (UC). Among the main oral manifestations of IBD are cobblestoning of the oral mucosa, labial swellings with vertical fissures, pyostomatitis vegetans, angular cheilitis, perioral erythema, and glossitis. In this sense, understanding these nosological entities by dentists would help reach early and differential diagnosis. Thus, two case reports are presented and discussed based on theoretical references obtained by a literature review. The first case report refers to an adult patient whose IBD diagnosis was established after stomatological assessment. The second case was a patient with CD diagnosed in childhood with characteristic oral lesions.

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Section: Discussionmentioning

confidence: 99%

Oral Manifestations of Inflammatory Bowel Diseases: Two Case Reports

Pereira

Munerato

2016

Clinical Medicine & Research

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“…Finally, the most common lesions encountered are nonspecific lesions that may occur in association with IBD, but also in its absence (Figure ). Of note, in CD, the macroscopic and histological appearances of oral lesions often resemble the gastrointestinal tract lesions while in patients with UC oral lesions are histologically unrelated to lesions found in the colon …”

Section: Spectrum Of Oral Manifestations In Ibdmentioning

confidence: 99%

“…Of note, in CD, the macroscopic and histological appearances of oral lesions often resemble the gastrointestinal tract lesions while in patients with UC oral lesions are histologically unrelated to lesions found in the colon. 50 Highly specific oral lesions Highly specific oral lesions are almost pathognomonic for IBD diagnosis as they show typical morphology or/ and histology. These lesions are orofacial and granulomatous cheilitis (Figure 2a,b) in patients with CD and pyostomatitis vegetans in patients with UC and CD ( Figure 6).…”

Section: Spectrum Of Oral Manifestations In Ibdmentioning

confidence: 99%

Review article: non‐malignant oral manifestations in inflammatory bowel diseases

Κατσάνος

Torres

Roda

et al. 2015

Aliment Pharmacol Ther

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Summary Background Patients with inflammatory bowel diseases (IBD) may present with lesions in their oral cavity. Lesions may be associated with the disease itself representing an extraintestinal manifestation, with nutritional deficiencies or with complications from therapy. Aim To review and describe the spectrum of oral nonmalignant manifestations in patients with inflammatory bowel diseases [ulcerative colitis (UC), Crohn's disease (CD)] and to critically review all relevant data. Methods A literature search using the terms and variants of all nonmalignant oral manifestations of inflammatory bowel diseases (UC, CD) was performed in November 2014 within Pubmed, Embase and Scopus and restricted to human studies. Results Oral lesions in IBD can be divided into three categories: (i) lesions highly specific for IBD, (ii) lesions highly suspicious of IBD and (iii) nonspecific lesions. Oral lesions are more common in CD compared to UC, and more prevalent in children. In adult CD patients, the prevalence rate of oral lesions is higher in CD patients with proximal gastrointestinal tract and/or perianal involvement, and estimated to range between 20% and 50%. Oral lesions can also occur in UC, with aphthous ulcers being the most frequent type. Oral manifestations in paediatric UC may be present in up to one‐third of patients and are usually nonspecific. Conclusions Oral manifestations in IBD can be a diagnostic challenge. Treatment generally involves managing the underlying intestinal disease. In cases presenting with local disabling symptoms and impaired quality of life, local and systemic medical therapy must be considered and/or oral surgery may be required.

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“…Other types of oral ulceration have been described in patients with inflammatory bowel disease; pyostomatitis gangrenosum is rare but manifests as deep, foul‐smelling ulceration (Figure 5) with an irregular outline and rolled margins 71 ,. 72 …”

Section: Pyostomatitis and Inflammatory Bowel Diseasementioning

confidence: 99%

Oral ulceration – aetiopathogenesis, clinical diagnosis and management in the gastrointestinal clinic

Field

Allan

2003

Aliment Pharmacol Ther

150

124

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Summary Oral ulceration is a common complaint of patients attending out‐patient clinics. The aim of this review is to provide the gastroenterologist with a differential diagnosis of oral ulceration, and a practical guide for the management of recurrent aphthous stomatitis, including topical and systemic therapy. The association of recurrent aphthous stomatitis with Behçet's disease and other systemic disorders, including coeliac disease, is discussed. Recent evidence concerning the immunopathogenesis of Behçet's disease is reviewed, including renewed interest in the role of Streptococcus sanguis and possible infectious triggering of an inappropriate immunoinflammatory response, resulting in tissue damage. The efficacy and limitations of conventional treatment for this mutisystem disorder are outlined together with the potential role of novel biological agents, such as anti‐tumour necrosis factor‐α therapy. Oral ulceration, as a manifestation of inflammatory bowel disease and a complication of drug therapy, is described. Guidance is given concerning indications for referral of patients with oral ulceration to an oral physician/surgeon for further investigations, including biopsy if appropriate.

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Oral manifestations of Crohn's disease.

Cited by 111 publications

References 27 publications

Oral Manifestations of Inflammatory Bowel Diseases: Two Case Reports

Oral Manifestations of Inflammatory Bowel Diseases: Two Case Reports

Review article: non‐malignant oral manifestations in inflammatory bowel diseases

Oral ulceration – aetiopathogenesis, clinical diagnosis and management in the gastrointestinal clinic

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