Oral manifestations of celiac disease in French children

Moreau, L; Dicky, Odile; Mas, Emmanuel; Noirrit, Emmanuelle; Marty, Mathieu; Vaysse, Frédéric; Olives, J. P.

doi:10.1016/j.arcped.2020.11.002

Cited by 11 publications

(12 citation statements)

References 20 publications

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“…Only one case–control study, using a smaller sample size, failed to show an association [ 7 ]. We found also that DEDs are more prevalent in children with CD than healthy controls, where children with CD had a greater prevalence of DEDs, supporting some previously reported studies [ 7 , 11 , 12 , 15 , 24 , 25 ]. Conversely, one study reported no difference in the prevalence of DEDs in CD children and controls [ 23 ].…”

Section: Discussionsupporting

confidence: 91%

“…In the present study, CD increased the likelihood of having RAS by about 4.03 times healthy controls, in agreement with one previous study, which reported a similar odds ratio (OR = 4.12) [ 23 ]. Several studies also reported a greater occurrence of RAS in children with CD than healthy controls [ 11 , 12 , 15 , 24 , 25 ]. Only one case–control study, using a smaller sample size, failed to show an association [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Oral manifestations of CD have been the focus of numerous studies. Generally, studies report on a single manifestation or multiple oral manifestations [ 3 , 4 , 7 – 9 , 15 , 22 ]. In the present study, CD increased the likelihood of having RAS by about 4.03 times healthy controls, in agreement with one previous study, which reported a similar odds ratio (OR = 4.12) [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…In general, understanding of CD among many health care professionals, especially dentists, is minimal, so delayed diagnosis of CD is not unusual [ 15 ]. To the best of the authors’ knowledge, there is currently no detailed and comprehensive study that examines oral features in children with CD, including soft and hard tissues, dental caries, and orthodontic needs.…”

Section: Introductionmentioning

confidence: 99%

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Oral and dental manifestations of celiac disease in children: a case–control study

Alsadat¹,

Alamoudi

El‐Housseiny

et al. 2021

BMC Oral Health

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Background Celiac disease (CD) is an immune-mediated enteropathy. CD may also involve complications with the oral cavity, which can result in various dental and oral pathologies. There are currently a limited number of studies on the oral manifestation of CD. This study aims to compare the oral manifestations of children with CD against healthy controls in Saudi Arabia. Materials and methods This study includes 208 children aged 6–14 years, distributed equally into CD patients and healthy controls. A parent completed and validated the interview questionnaire, which included the child's personal information and medical history. A dental examination was undertaken to measure possible recurrent aphthous stomatitis (RAS), dental enamel defects (DEDs), dental caries experience, and dental malocclusion. Data were analyzed using descriptive statistics and bivariate and multivariate analysis. Results Two hundred and eight participants were included (104 CD patients and 104 controls). The mean age for CD patients was 10.67 ± 2.39 years and 10.69 ± 2.36 for the healthy controls. CD children had more RAS than controls (42.3% vs. 15.4%, P < 0.001) (OR = 4.03, 95% CI = 2.09–7.81) and more DEDs than healthy controls (70.2% vs. 34.6%, P < 0.001) (OR = 4.45, 95% CI = 2.48–7.97). No significant difference was found in the frequency of malocclusion between cases and controls. Conclusion Saudi Arabian children with CD had a greater number of clinical findings of RAS and DEDs than healthy controls. Pediatric dentists should consider the possibility of CD in child patients presenting with RAS or DEDs.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Oral and dental manifestations of celiac disease in children: a case–control study

Alsadat¹,

Alamoudi

El‐Housseiny

et al. 2021

BMC Oral Health

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“…Among these, some are quite common and well-known as they are directly correlated to absorption alterations and consequent deficiency status (e.g., osteoporosis due to calcium/vitamin D deficit or iron-deficiency anemia). Nevertheless, other possible extra-intestinal manifestations are less frequent and they really constitute the “atypical or non-classic” form of CD [ 1 , 4 , 5 ]. These include cutaneous disorders, neuropsychiatric features, abnormal liver functions, reproductive abnormalities, and endocrinological manifestations ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?

Durazzo

Ferro

Brascugli

et al. 2022

JCM

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Celiac disease (CD) is a chronic, small-intestinal, immune-mediated enteropathy due to gluten exposition in genetically predisposed individuals. It occurs in about 1% of the population and often remains an underdiagnosed condition. This could be due to the fact that the adult population often lacks the classical signs and symptoms of CD, manifesting only atypical symptoms. In this review we analyzed the main extra-intestinal manifestations of CD which include cutaneous and endocrinological disorders, abnormal liver function tests, and neuropsychiatric features. When CD is not diagnosed and therefore is not treated with a gluten-free diet (GFD), it can predispose to severe complications, not only gastrointestinal. Thus, it is important for clinicians to quickly recognize the atypical manifestations of CD, considering that an early diagnosis can significantly impact on a patient’s prognosis.

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Oral Health-Related Quality of Life in Celiac Portuguese Children: a cross-sectional study

Coelho,

Bernardo,

Mendes

2023

Eur Arch Paediatr Dent

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Purpose Celiac Disease (CD) presents a wide variety of clinical signs and symptoms, including oral manifestations. This study pretended to characterize Oral Health-Related Quality of Life (OHRQoL) and reported oral manifestations in children with CD. Methods Target-population were children with CD. An online questionnaire, applied to children’s parents, collected information about OHRQoL (using the Early Childhood Oral Health Impact Scale—ECOHIS), oral health behaviours, and history of oral manifestations. Data analysis included descriptive statistics, Mann–Whitney, Kruskall-Wallis, and Spearman correlation tests (α = 0.05). Results The sample included 146 celiac patients, with a mean age of 10.5 years (sd = 4.1). Mean ECOHIS score was 5.2 (sd = 6.8). The most frequently reported oral manifestations were recurrent aphthous stomatitis (46.6%), dental caries (45.2%) and dental opacity (39%). About one third of the participants mentioned improvements in oral health when a gluten-free diet was introduced. Most of the reported oral manifestations had a significant association with the ECOHIS score (p < 0.05). Conclusions The OHRQoL of children was good, however oral manifestations had a negative impact on OHRQoL. The most reported oral manifestations were recurrent aphthous stomatitis, dental caries, and dental opacities. Oral health professionals must be aware about the heterogeneity of the disease, to recognize oral manifestations associated and their importance in the early diagnosis to reduce complications and to an improvement in the OHRQoL of these patients.

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Oral manifestations of celiac disease in French children

Cited by 11 publications

References 20 publications

Oral and dental manifestations of celiac disease in children: a case–control study

Oral and dental manifestations of celiac disease in children: a case–control study

Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?

Oral Health-Related Quality of Life in Celiac Portuguese Children: a cross-sectional study

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