Oral manifestations in patients with gastro‐oesophageal reflux disease: a single‐center case–control study

Fede, Olga Di; Liberto, Chiara Di; Occhipinti, Giuseppe; Vigneri, Sergio; Russo, Lucio Lo; Fedele, Stefano; Muzio, Lorenzo Lo; Campisi, Giuseppina

doi:10.1111/j.1600-0714.2008.00646.x

Cited by 81 publications

(89 citation statements)

References 62 publications

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“…this erythema and mucosal atrophy may be present as a result of chronic exposure of tissues to acid (5). Oral complaints GERD patients often mention other oral complaints such as sensitation of burning or heat in the mouth, halitosis, xerostomia, dysgeusia -foul taste, and dental sensitivity related to hot or cold drinks or foods due to the erosions (5,9,18,20).…”

Section: Oral Mucosa Lesionsmentioning

confidence: 99%

Oral Cavity and Systemic Diseases—Gastroesophageal Reflux Disease

Krasteva

Panov

Kisselova

et al. 2012

Biotechnology & Biotechnological Equipment

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Section: Oral Mucosa Lesionsmentioning

confidence: 99%

Oral Cavity and Systemic Diseases—Gastroesophageal Reflux Disease

Krasteva

Panov

Kisselova

et al. 2012

Biotechnology & Biotechnological Equipment

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“…5,14 However, other studies have proposed a significant relationship between halitosis and GERD (Table 4). [16][17][18][19]29 16,29 In these studies, the erosive reflux disease group had higher VSC values than the NERD group. However, these studies lacked a true control group, such as healthy subjects.…”

Section: Discussionmentioning

confidence: 72%

“…5 Recently, gastroesophageal reflux disease (GERD) has been reported to be one of the causes of halitosis. [15][16][17][18][19] Moreover a study has reported that GERD-related symptoms were associated with halitosis, regardless of the oral conditions. 17 In contrast, some studies have reported that halitosis is not associated with erosive GERD.…”

Section: Introductionmentioning

confidence: 99%

“…[17][18][19] A Halimeter (RH-17K; Interscan Co., Chatsworth, CA, USA) has been introduced for diagnosis of halitosis by detecting VSCs, and is considered as an objective test for halitosis. The aim of this study was to investigate an association between GERD and halitosis diagnosed by self-reported questionnaires and VSCs measurements by the Halimeter.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Halitosis Diagnosed by a Questionnaire and Halimeter and Symptoms of Gastroesophageal Reflux Disease

Lee¹,

Kim²,

Kim³

et al. 2014

J Neurogastroenterol Motil

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Background/Aims The relationship between halitosis and gastroesophageal reflux disease (GERD) remains controversial. The aim of this study was to investigate an association between subjective and objective halitosis and GERD. Methods The subjects were enrolled from participants who visited a health promotion center at Seoul National University Bundang Hospital. For diagnosis of halitosis, a questionnaire was requested, and volatile sulfur compounds (VSCs) were measured by Halimeter. Self-conscious halitosis was defined as halitosis perceived by himself or herself. Informed halitosis was defined as halitosis perceived by others. Objective halitosis was defined when mean VSCs values were > 100 parts per billion. GERD was defined based on a questionnaire and endoscopy, including erosive esophagitis and non-erosive reflux disease (NERD). Results A total of 54 subjects (male:female = 33:21) with mean age of 46.0 ± 11.4 years were analyzed. The mean VSCs values were not significantly different between presence and absence of self-conscious halitosis ( P = 0.322), but significantly different between presence and absence of informed halitosis ( P = 0.021). Informed halitosis was associated with objective halitosis ( P = 0.039). GERD, erosive esophagitis and NERD did not correlate with objective halitosis ( P = 0.556, 0.206 and 0.902, respectively). In multivariable analysis, the relationship between objective halitosis and GERD symptoms including chest pain, heart burn, acid regurgitation, epigastric pain, hoarseness, globus sensation and coughing was not significant. Besides, GERD was not associated with self-conscious halitosis, informed halitosis and objective halitosis, respectively. Conclusions GERD might not be associated with self-conscious, informed halitosis and objective halitosis indicated by Halimeter results. Informed halitosis could be correlated with objective halitosis determined by the Halimeter.

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“…3,4 This condition may worsen if bad oral hygiene is associated. 5,6 The detection of these oral lesions in GERD patients is a top priority; considering the link between lesion severity and acid reflux disease, an effective management of oral pH is needed.…”

Section: Discussionmentioning

confidence: 99%

Original Research. Evaluation of Dental Erosion in a Group of Romanian Children Diagnosed with Gastroesophageal Reflux Disease

Martha

Ogodescu

Eșian

et al. 2017

Journal of Interdisciplinary Medicine

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Gastroesophageal reflux disease (GERD) is a very common digestive disorder, which occurs when the acidic contents of the stomach returns into the esophagus to some extent, reaching the mouth, thereby increasing the frequency of dental erosion and caries. Since saliva plays a huge role in oral homeostasis, it is important to examine the role of this parameter in the appearance of the above mentioned oral lesions. The aim of our study was evaluate the oral condition of children suffering from reflux disease and to assess the relationship between salivary pH and the incidence of dental erosion and caries. In this prospective study we examined 25 children diagnosed with GERD, referred for hospitalization. Bedside intra-oral examination (DMFT index, gingival index) and strip method pH value determination was performed. We observed that patients with low pH values had increased caries frequency, and dental erosion was also noticeable. Statistical significance was determined comparing the DMFT index in groups with different pH values. We concluded that the high number of erosions is closely related to gastroesophageal reflux disease, as a consequence of the low pH value, which represents the main cause of oral manifestations in GERD.

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Oral manifestations in patients with gastro‐oesophageal reflux disease: a single‐center case–control study

Abstract: This study failed to find any significant association between GERD and dental erosions, whereas some symptoms and other objective oral mucosal changes were found to be significantly associated with GERD.

Cited by 81 publications

References 62 publications

Oral Cavity and Systemic Diseases—Gastroesophageal Reflux Disease

Oral Cavity and Systemic Diseases—Gastroesophageal Reflux Disease

Association Between Halitosis Diagnosed by a Questionnaire and Halimeter and Symptoms of Gastroesophageal Reflux Disease

Original Research. Evaluation of Dental Erosion in a Group of Romanian Children Diagnosed with Gastroesophageal Reflux Disease

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