Oral manifestations in 101 Cambodian patients with HIV infection and AIDS

Bendick, Christoph; Scheifele, Christian; Reichart, Peter A.

doi:10.1034/j.1600-0714.2002.310101.x

Cited by 54 publications

(20 citation statements)

References 10 publications

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“…However, other Asian studies from Thailand 24.8 %(8), Cambodia 22.8% (10) and Singapore 35%(14) showed similar prevalence. Of the oral candidiasis, erythematous candidiasis (13 cases; 16%) was the most common followed by pseudomembranous candidiasis (4 cases; 4.9%) and least by angular cheilitis (1 case; 1.2%).…”

Section: Discussionmentioning

confidence: 66%

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Oral lesions and immune status of HIV infected adults from eastern Nepal

Naidu¹,

Thakur²,

Singh³

et al. 2013

J Clin Exp Dent

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Objective: To document the prevalence, age and gender distribution of oral lesions in HIV infected adults and the influence of highly active antiretroviral therapy and correlate them to the immune status of the patients. Materials and Methods: Oral lesions were diagnosed by a detailed physical examination by trained and calibrated examiners according to the case definitions established by the Oral HIV/AIDS research alliance. Demographic details, risk behavior patterns and oral symptoms and habits were collected by a questionnaire. Results: 81 patients; 54 men and 27 women aged between 20 – 55 years participated in the study. A total of 49 patients; 60.5% had some oral lesion when examined. Oral candidiasis (21 %) and oral melanosis (21%) were the most common lesions, followed by linear gingival erythema, oral hairy leukoplakia, necrotizing ulcerative periodontitis/gingivitis, herpes labialis, parotid gland enlargement and reccurent apthous ulcers. Oral hairy leukoplakia was exclusively seen in men (p=0.018). All six cases of herpes simplex lesion were seen in non - anti retro viral group (p=0.073) while oral candidiasis was commonly noted in the anti retro viral group (p=0.073). Lowering CD4 counts had the strongest association with the prevalence of oral candidasis (p=0.012), pseudomembranous candidiasis (p=0.014) and oral hairy leukoplakia (p= 0.065). Conclusion: This study shows a high prevalence of oral candidiasis, melanosis, linear gingival erythema and oral hairy leukoplakia in the patients. Key words:HIV, AIDS, oral lesions, prevalence.

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Section: Discussionmentioning

confidence: 66%

“…However, previous studies in Thailand (82 %) (8), India (86%) (9) and Cambodia (90%)(10)have reported a higher prevalence. The lesions ranged from a single to a maximum of 4 lesions per subject.…”

Section: Discussionmentioning

confidence: 78%

Oral lesions and immune status of HIV infected adults from eastern Nepal

Naidu¹,

Thakur²,

Singh³

et al. 2013

J Clin Exp Dent

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“…In Cambodia, the HIV/AIDS epidemic has become a major issue in recent years (Bendick et al , 2002). In one study, a total of 381 cases of HIV-infected patients admitted to a public hospital in Phnom Penh between 1999 and 2000 were reviewed, and chronic diarrhea was the most frequent (41.2%) HIV-related problem, whereas PcP was identified in only 8.4% of the patients (Senya et al , 2003).…”

Section: Introductionmentioning

confidence: 99%

Pneumocystis jiroveciipneumonia in developing countries

et al. 2011

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Pneumocystis pneumonia (PcP) is a serious fungal infection among immunocompromised patients. In developed countries, the epidemiology and clinical spectrum of PcP have been clearly defined and well documented. However, in most developing countries, relatively little is known about the prevalence of pneumocystosis. Several articles covering African, Asian and American countries were reviewed in the present study. PcP was identified as a frequent opportunistic infection in AIDS patients from different geographic regions. A trend to an increasing rate of PcP was apparent in developing countries from 2002 to 2010.

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“…They have also been considered of value as indicators of success or failure of antiretroviral therapy. It has been reported that HAART has a marked effect on the prevalence and clinical appearance on HIV- related oral lesions [6]. These effects vary from review of the literatures.…”

Section: Introductionmentioning

confidence: 99%

The impact of Highly Active Antiretroviral Therapy (HAART) on the clinical features of HIV - related oral lesions in Nigeria

Taiwo¹,

Hassan

2010

AIDS Res Ther

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BackgroundThis study aimed to determine the therapeutic effects of highly active anti-retroviral therapy (HAART) on the clinical presentations of HIV related oral lesions (HIV-ROLs) in an adult Nigerian population.MethodsA 5 month prospective study on HAART naïve HIV positive adults recruited into the HAART program of an AIDS referral centre. HIV-ROLs were diagnosed clinically by the EEC Clearinghouse on oral problems related to HIV infection. Baseline clinical features of HIV-ROLs was documented by clinical photographs using SONY® 5.2 M Cybershot digital camera. Post HAART monthly review was conducted using clinical photographs.ResultsA total of 142 patients were seen. Age range was 19 - 75 years. Mean age was 35.6 ± 10.5 (SD). Eighty (56.3%) were females. Prevalence of HIV-ROLs was 43.7%. Oral candidiasis (22.4%) was the most prevalent HIV-ROL. 114 (83.2%) patients had clinical AIDS at presentation (CDC 1993). 89.4% were placed on Tenofovir/Emtricitabine +`Nevirapine, 9.9% on Tenofovir/Emtricitabine + Efavirenz. There was strong decline in the clinical features of oral candidiasis from a month of commencing HAART. Oral hairy leukoplakia was slow in responding to HAART. Parotid gland enlargement, melanotic hyperpigmentation and Kaposi's sarcoma were more persistent and had slower response to HAART. There was no clinical change noticed in linear gingival erythema.ConclusionHAART has different clinical effects on HIV related oral lesions depending on the size, duration of treatment and etiology of the lesions. HIV-ROLs of fungal origin have the fastest response to HAART. These lesions alongside immunologic parameters can be used as indicators of success or failure of antiretroviral therapy.

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Oral manifestations in 101 Cambodian patients with HIV infection and AIDS

Cited by 54 publications

References 10 publications

Oral lesions and immune status of HIV infected adults from eastern Nepal

Oral lesions and immune status of HIV infected adults from eastern Nepal

Pneumocystis jiroveciipneumonia in developing countries

The impact of Highly Active Antiretroviral Therapy (HAART) on the clinical features of HIV - related oral lesions in Nigeria

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