Oral management with polaprezinc solution reduces adverse events in haematopoietic stem cell transplantation patients

Tsubura-Okubo, Maki; Komiyama, Yuske; Kamimura, Ryouta; Sawatani, Yuta; Arai, Honoka; Mitani, Kinuko; Haruyama, Yasuo; Kobashi, Gén; Ishihama, Hiromi; Uchida, Daisuke; Kawamata, Hitoshi

doi:10.1016/j.ijom.2020.10.004

Cited by 4 publications

(5 citation statements)

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“…[ 28 ] Moreover, oral management significantly decreased the incidence of oral adverse events (oral mucositis) during treatment, before and after HSCT in inpatients with hematopoietic neoplasms. [ 29 , 30 ] Systemic antibiotic prophylaxis, such as the preoperative administration of metronidazole and amoxicillin combination, is reportedly effective in improving the treatment outcomes and prognosis of patients with severe periodontitis [ 31 , 32 ] and HSCT. [ 33 ] Despite strong evidence of the role of oral health in the prevention of life-threatening infections in hematology inpatients, to our knowledge, an association between oral health assessments and the detection of GNB in hematology inpatients has not been reported so far.…”

Section: Introductionmentioning

confidence: 99%

“…Yamada et al indicated that myelosuppressed/immunosuppressed conditions in cancer treatment require intervention during the perioperative oral management [28] . Moreover, oral management significantly decreased the incidence of oral adverse events (oral mucositis) during treatment, before and after HSCT in inpatients with hematopoietic neoplasms [29,30] . Systemic antibiotic prophylaxis, such as the preoperative administration of metronidazole and amoxicillin combination, is reportedly effective in improving the treatment outcomes and prognosis of patients with severe periodontitis [31,32] and HSCT [33] .…”

Section: Introductionmentioning

confidence: 99%

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Association between the point-rating system used for oral health and the prevalence of Gram-negative bacilli in hematological inpatients

et al. 2021

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Gram-negative bacteremia is a major cause of death among hematology inpatients who require heavy-dose chemotherapy and hematopoietic stem cell transplantation. Gram-negative bacillus (GNB) is more likely to be detected when the oral health is poor. However, there is a dearth of studies on the relationship between oral assessment and prevalence of GNB in hematology inpatients. This retrospective study aimed to evaluate the relationship between the original point-rating system for oral health examinations (point-oral exam) and the prevalence of GNB in hematology inpatients at the hematology ward of the Yamanashi University Hospital. GNB was detected by cultivating samples from the sputum and blood of each patient. A total of 129 subjects underwent a medical checkup and point-oral exam. The sputum and blood culture results of 55 patients were included in this study. The total points of patients positive for GNB (n = 25, 45.5%) were significantly higher than those who were negative for GNB (total score: median, 25th, 75th, percentile; 6 [4, 7] vs 2 [1, 4]; P = .00016). Based on the receiver operating characteristic analysis, a cutoff score of 5 proved to be most useful to detect GNB. An oral evaluation with a cutoff value of 5 or higher in the point-oral exam might indicate the need for a more thorough oral management to prevent the development of systemic infections from GNB.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between the point-rating system used for oral health and the prevalence of Gram-negative bacilli in hematological inpatients

et al. 2021

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“…In addition, all controls needed opioids against the 30% of children who received P-AG [20]. Eventually, Tsubura-Okubo et al observed the reduction in pain, taste disorders, and incidence of oral mucositis by rinsing and swallowing ZnC in polyacrylic acid solution (PPAA) in patients that received chemotherapy and HSCT [22]. In addition, the severity of acute graft-versus-host disease (GVHD) was significantly lower in patients that received PPAA than in controls [22].…”

Section: Discussionmentioning

confidence: 99%

“…Eventually, Tsubura-Okubo et al observed the reduction in pain, taste disorders, and incidence of oral mucositis by rinsing and swallowing ZnC in polyacrylic acid solution (PPAA) in patients that received chemotherapy and HSCT [22]. In addition, the severity of acute graft-versus-host disease (GVHD) was significantly lower in patients that received PPAA than in controls [22]. Taste disorders are another intraoral clinical application of ZnC because zinc is a cofactor of taste buds' enzymes [6].…”

Section: Discussionmentioning

confidence: 99%

The Effect of a Zinc-L-Carnosine Mouthwash in the Management of Oral Surgical Wounds: Preliminary Results of a Prospective Cohort Study

et al. 2023

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Background: Zinc L-carnosine promotes the transition from the inflammatory to the proliferative phase of wound healing by reducing the expression of pro-inflammatory signals and enhancing the expression of anti-inflammatory signals. This prospective cohort study aims to test the effect of a zinc–L-carnosine mouthwash in promoting oral surgical wound healing. Methods: From October 2022 to February 2023, the authors enrolled healthy adult volunteers who needed the extraction of bilateral molars at the Unit of Dentistry of the University of Bari. The authors studied the baseline wound healing of each patient after the first extraction. Three months later, the patients underwent the second extraction and rinsed their mouths with zinc–L-carnosine mouthwash twice per day for the following 28 postoperative days. For a month after each extraction, the patients received weekly follow-up visits by an oral surgeon blinded about the study to record the modified healing index score of the wounds (range 0–6 points). For statistical analysis, we used the one-tailed t-test for paired samples with a significance level set at p < 0.05 to compare the baseline scores with those recorded during the exposure to the zinc–L-carnosine mouthwash. Results: The authors enrolled four women and six men (mean age = 44.60 ± 19.22 years). On the seventh and fourteenth postoperative days, the mean difference between the modified healing index scores obtained by using the zinc–L-carnosine mouthwash and the baseline was not significant. On the twenty-first postoperative day, the mean score obtained by using the mouthwash was 5.2 ± 1.3 points and was significantly higher than the 4.7 ± 1.8 points of the baseline (p = 0.026). On the twenty-eighth postoperative day, the mean difference was significant as well (5.9 ± 0.3 points and 5.4 ± 1.1 points, respectively). Conclusion: The preliminary results of this study showed that the zinc–L-carnosine mouthwash improved the quality of oral surgical wound healing.

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“…On the other hand, Yamagata et al reported that dental treatment to control infected areas and sources of infection with proper cleaning procedures prior to HSCT treatment resulted in the absence of any dental infections in the patients after transplantation [21]. Moreover, oral management signi cantly decreased the incidence of oral adverse events (oral mucositis) during treatment before and after HSCT in inpatients with hematopoietic neoplasms [22,23].…”

Section: Introductionmentioning

confidence: 99%

Association Between The Point-Rating System Used for Oral Health and The Prevalence of Gram-Negative Bacilli in Hematological Inpatients: A Prospective Observational Study

Yoshizawa

Moroi

Iguchi

et al. 2021

Preprint

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Background: Gram-negative bacteremia is a major cause of death among hematology inpatients who require heavy-dose chemotherapy and hematopoietic stem cell transplantation. Gram-negative bacillus (GNB) is more likely to be detected when the oral health is poor. However, there is a dearth of studies on the relationship between oral assessment and prevalence of GNB in hematology inpatients.Methods: This prospective study aimed to evaluate the relationship between the original point-rating system for oral health examinations (point-oral exam) and the prevalence of GNB in hematology inpatients at the hematology ward of the Yamanashi University Hospital. GNB was detected by cultivating samples from the sputum and blood of each patient.Results: A total of 129 subjects underwent a medical checkup and point-oral exam. The sputum and blood culture results of 55 patients were included in this study. The total points of patients positive for GNB (n = 25, 45.5%) were significantly higher than those who were negative for GNB (total score: median, 25th, 75th, percentile; 6 (4, 7) vs 2 (1, 4); p = 0.00016). Based on the receiver operating characteristic analysis, a cutoff score of 5 proved to be most useful to detect GNB.Conclusion: An oral evaluation with a cutoff value of 5 or higher in the point-oral exam might indicate the need for a more thorough oral management to prevent the development of systemic infections from GNB.

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Oral management with polaprezinc solution reduces adverse events in haematopoietic stem cell transplantation patients

Abstract: Oral management with polaprezinc solution reduces adverse events in haematopoietic stem cell transplantation patients.

Cited by 4 publications

References 26 publications

Association between the point-rating system used for oral health and the prevalence of Gram-negative bacilli in hematological inpatients

Association between the point-rating system used for oral health and the prevalence of Gram-negative bacilli in hematological inpatients

The Effect of a Zinc-L-Carnosine Mouthwash in the Management of Oral Surgical Wounds: Preliminary Results of a Prospective Cohort Study

Association Between The Point-Rating System Used for Oral Health and The Prevalence of Gram-Negative Bacilli in Hematological Inpatients: A Prospective Observational Study

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