Oral malignant melanoma

Malignant mucosal melanoma of the head and neck — a review

“…3,7,50 Mucosal melanomas are characterized by multiplicity, satellite formation, local and angiolymphatic invasion, consecutive pronounced local, regional and distant dissemination and a high rate of cause-specific death. 5,32,45 The standard primary treatment is surgical , in spite of the frequent local recurrences and regional or distant spread. In a majority of the cases, radiotherapy and systemic therapy have been used as palliative modalities, though there is evidence of their occasional beneficial effect.…”

“…41,45,51 Local recurrences are also related to satellite formation, angiolymphatic invasion and a submucosal spread. 32,45,51 Neither local control nor survival is affected by negative surgical margins, but wide surgical resection is recommended, with preservation of vital structures whenever possible. 27 Guzzo reported on 48 cases with mucosal melanomas in the head and neck region, most of whom were treated by surgery alone.…”

Malignant melanoma in childhood and adolescence: Report of 13 cases

“…53 The prognosis of oral mucosal melanoma is poor, with 5-year survival rates reported between 13% and 20%. 54,55 To date, only 5 cases have been reported in patients younger than 20 years. 54,[56][57][58] There are no follow-up data for 3 of these patients.…”

Clinical features of the head and neck mucosal melanoma. А review

“…Так, у японцев частота встречаемости МСО на-много выше (8 % всех меланом) по сравнению с пока-зателями у пациентов европеоидной расы (1 %) [21][22][23][24]. Более того, 7,5 % всех меланом у японцев развиваются в полости рта (1 % у пациентов европеоидной расы) [25,26].…”