Oral Magnesium Load Test in Patients With Migraine

Trauninger, Anita; Pfund, Zoltán; Kőszegi, Tamás; Czopf, J

doi:10.1046/j.1526-4610.2002.02026.x

Cited by 40 publications

(32 citation statements)

References 39 publications

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“…A lowered magnesium level in cellular concentrations could be an indicator of low cerebral levels, which could add to a lowered threshold for migraine headaches. A magnesium load test study (Trauninger et al 2002) revealed that greater retention of magnesium occurred in patients suffering from migraines compared to healthy controls, suggesting a systemic deficiency. A 2-week trial revealed that when migraine patients drank water with magnesium, their total magnesium significantly increased in erythrocytes.…”

Section: Pathophysiologymentioning

confidence: 99%

Why all migraine patients should be treated with magnesium

Mauskop¹,

Varughese

2012

J Neural Transm

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Section: Pathophysiologymentioning

confidence: 99%

Why all migraine patients should be treated with magnesium

Mauskop¹,

Varughese

2012

J Neural Transm

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“…However, subjects in the Mg 2+ group showed slight rises in urinary Mg 2+ (+9 to 11%) while those in placebo group showed a substantial decrease in urinary Mg 2+ (-32%). Possibly the decreased urinary Mg 2+ excretion in the placebo cream group represents more active physiological Mg 2+ retention processes that are not apparent in the Mg cream group ([15,16]. It has been suggested that 24-hour urine excretion of Mg 2+ may be a better indicator of tissue status than the serum Mg 2+ concentration, but it is highly variable and it is questionable whether it can be used to reliably assess a given individual’s Mg 2+ status.…”

Section: Discussionmentioning

confidence: 99%

“…Since less than 1% of magnesium is contained in the blood, assessment by serum status may be problematic [3]. It is often considered that 24-hr urine excretion of Mg 2+ may be a better indicator of intestinal absorption than serum concentration; however, urinary Mg 2+ excretion is also highly variable and it is questionable whether it can be used reliably to assess an individual’s Mg 2+ status [15]. However, serum Mg 2+ can reflect a longer term dietary Mg 2+ status over weeks or months whilst urinary Mg 2+ can be a better marker of one’s recent dietary intake [16].…”

Section: Introductionmentioning

confidence: 99%

Effect of transdermal magnesium cream on serum and urinary magnesium levels in humans: A pilot study

Kass

Rosanoff²,

Tanner

et al. 2017

PLoS ONE

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BackgroundOral magnesium supplementation is commonly used to support a low magnesium diet. This investigation set out to determine whether magnesium in a cream could be absorbed transdermally in humans to improve magnesium status.Methods and findingsIn this single blind, parallel designed pilot study, n = 25 participants (aged 34.3+/-14.8y, height 171.5+/-11cm, weight 75.9 +/-14 Kg) were randomly assigned to either a 56mg/day magnesium cream or placebo cream group for two weeks. Magnesium serum and 24hour urinary excretion were measured at baseline and at 14 days intervention. Food diaries were recorded for 8 days during this period. Mg test and placebo groups’ serum and urinary Mg did not differ at baseline. After the Mg2+ cream intervention there was a clinically relevant increase in serum magnesium (0.82 to 0.89 mmol/l,p = 0.29) that was not seen in the placebo group (0.77 to 0.79 mmol/L), but was only statistically significant (p = 0.02)) in a subgroup of non-athletes. Magnesium urinary excretion increased from baseline slightly in the Mg2+ group but with no statistical significance (p = 0.48). The Mg2+ group showed an 8.54% increase in serum Mg2+ and a 9.1% increase in urinary Mg2+ while these figures for the placebo group were smaller, i.e. +2.6% for serum Mg2+ and -32% for urinary Mg2+. In the placebo group, both serum and urine concentrations showed no statistically significant change after the application of the placebo cream.ConclusionNo previous studies have looked at transdermal absorbency of Mg2+ in human subjects. In this pilot study, transdermal delivery of 56 mg Mg/day (a low dose compared with commercial transdermal Mg2+ products available) showed a larger percentage rise in both serum and urinary markers from pre to post intervention compared with subjects using the placebo cream, but statistical significance was achieved only for serum Mg2+ in a subgroup of non-athletes. Future studies should look at higher dosage of magnesium cream for longer durations.Trial registrationISRCTN registry ID No. ISRTN15136969

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“…62 Studies have shown that migraineurs have low brain magnesium during migraine attacks 63 and may also have a systemic magnesium deficiency. 64,65 Furthermore, a deficiency of magnesium may play a particularly important role in menstrual migraine. 66 Two double-blind, placebocontrolled trials have shown that oral magnesium supplementation is effective in headache prevention.…”

Section: Vitamins and Other Supplements In The Prevention Of Migrainementioning

confidence: 99%

Foods and Supplements in the Management of Migraine Headaches

Sun-Edelstein¹,

Mauskop²

2009

The Clinical Journal of Pain

113

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Objective: Although a wide range of acute and preventative medications are now available for the treatment of migraine headaches, many patients will not have a significant improvement in the frequency and severity of their headaches unless lifestyle modifications are made. Also, given the myriad side effects of traditional prescription medications, there is an increasing demand for ''natural'' treatment like vitamins and supplements for common ailments such as headaches. Here, we discuss the role of food triggers in the management of migraines, and review the evidence for supplements in migraine treatment.Methods: A review of the English language literature on preclinical and clinical studies of any type on food triggers, vitamins, supplements, and migraine headaches was conducted.Results: A detailed nutritional history is helpful in identifying food triggers. Although the data surrounding the role of certain foods and substances in triggering headaches is controversial, certain subsets of patients may be sensitive to phenylethylamine, tyramine, aspartame, monosodium glutamate, nitrates, nitrites, alcohol, and caffeine. The available evidence for the efficacy of certain vitamins and supplements in preventing migraines supports the use of these agents in the migraine treatment. Conclusions:The identification of food triggers, with the help of food diaries, is an inexpensive way to reduce migraine headaches. We also recommend the use of the following supplements in the preventative treatment of migraines, in decreasing order of preference: magnesium, Petasites hybridus, feverfew, coenzyme Q10, riboflavin, and alpha lipoic acid.

show abstract

Oral Magnesium Load Test in Patients With Migraine

Abstract: Magnesium retention occurs in patients with migraine after oral loading, suggesting a systemic magnesium deficiency.

Cited by 40 publications

References 39 publications

Why all migraine patients should be treated with magnesium

Why all migraine patients should be treated with magnesium

Effect of transdermal magnesium cream on serum and urinary magnesium levels in humans: A pilot study

Foods and Supplements in the Management of Migraine Headaches

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