Oral Loading of Tacrolimus and Sub-Therapeutic Levels on the Day of Transplant Do Not Predict the Incidence of Acute Graft Versus Disease or Survival After Allogeneic Stem Cell Transplant
Abstract:4543
Tacrolimus is proven to be effective in the prophylaxis of acute graft versus host disease (aGVHD) after allogeneic stem cell transplantation (ASCT). Published studies that initiate tacrolimus loading intravenously indicate that levels should be between 5 and 20ug/L on the day of transplant. Our institution often performs ASCT in the outpatient setting and therefore we developed a process for oral loading of tacrolimus. We retrospectively reviewed our experience in 94 consecutive patients (… Show more
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