Oral lichenplanus: Etiology, pathogenesis, diagnosis, and management

Gangeshetty, Naresh; Kumar, Bhumika

doi:10.5321/wjs.v4.i1.12

Cited by 14 publications

(33 citation statements)

References 55 publications

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Section: Resultsmentioning

confidence: 98%

“…Distribution of patients and control group according to age was listed in table (1), most patients (43.8%) were at age group (>50 years), however, there is no significant difference between this group and other age groups (p=0.102). There was female predominance among patients, as 20 (62.5%) of OLP patients were females, while only 12 (37.5%) of patients were males figure (1). While the distribution of patients according to clinical types the OLP patients were classified to three subgroups, (14 patients were reticular form and 11 of patients were with erosive form while 7 patients with plaque like form).…”

Section: Resultsmentioning

confidence: 98%

“…ral lichen planus (OLP) considered as a disease of stratified squamous epithelia (1) . The clinical estimate of the oral lesions is depended on the six clinical shapes: atrophic, bullous, erosive, papular, plaque and reticular (2) that usually cause bilateral white striations, papules, or plaques on the buccal mucosa, tongue, and gingiva.…”

Section: Introductionmentioning

confidence: 99%

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Detection of Hepatitis C Virus in Iraqi Patients With Oral Lichen Planus

2016

IJMS

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Background Oral Lichen planus (OLP) is chronic mucocutaneous disorder with or without involvement skin, of unknown etiology. Lichen planus (LP) is T-cell-mediated chronic inflammatory disease of the stratified squamous epithelium. It can affect oral mucosa, skin, esophagus, nasal mucosa, larynx, genitalia, urinary tract, hair follicles and the eyes. Latterly has been focused on presence association between OLP and hepatitis C virus (HCV) infection, but this relation is not stable, since the prevalence of this virus in patients varies depended on studies, ranging from 0% to 67.8%. ObjectiveThis study was established to investigate the relationship between the OLP and HCV infection in Iraq and to detect the virus by Real-time polymerase chain reaction (RT-PCR). MethodsBlood samples were collected from 62 patients with OLP and controls to detect the HCV in those patients by using one step anti-HCV test, ELISA test and RT-PCR. ResultsThe current study revealed that the early detection of HCV by one step Anti-HCV for all OLP patients was negative and by ELISA showed that four patients (12.5%) of OLP were positive for HCV. While using RT-PCR found that only one patient (3.1%) was positive for the presence of the virus. ConclusionThere was not relationship found between OLP and HCV infection in Iraqi patients.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 98%

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Detection of Hepatitis C Virus in Iraqi Patients With Oral Lichen Planus

2016

IJMS

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“…However, clinical diagnosis usually sufficesin classical lesions (Wickham's striae, erythematous area). 20 The characteristic clinical manifestations usually encompass bilaterally symmetrical reticular lesions. The essential histopathological features are liquefaction degeneration of the epithelial basal layer, hyperkeratosis with ortho and/or parakeratosis, band-like lymphocytic infiltrate in the connective tissue area, and sawtooth rete pegs.…”

Section: • Tuberculosismentioning

confidence: 99%

Desquamative Gingivitis as the Sole Manifestation in Oral Lichen Planus: Report of Case and Brief Literature Review

2020

IJFMT

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The Mouth is the mirror of the human body that reflects systemic disorders, and various systemic pathologies find expression in the oral region. Oral manifestations may be the initial feature or the only presenting sign in mucocutaneous diseases. Mucocutaneous disorders share two features in common: An immune-mediated pathogenesis and possibly common clinical appearance termed as 'Desquamative gingivitis'. Desquamative gingivitis is mostly a manifestation of a wide array of vesiculobullous disorders; however, it may also result due to endocrine disturbances, chronic infections, and allergic/chemical reactions. Hereby, presenting a case of oral lichen planus with Desquamative gingivitis as the sole manifestation in a 35-year-old female patient.

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“…The main purposes of OLP treatment are to relieve pain, cure erosion, and reduce the potential for carcinogenesis. Treatments for OLP include corticosteroids, calcineurin inhibitors, retinoids, azathioprine, lycopene, barbaloin, hyaluronic acid, bacillus Calmette-Guerin polysaccharide nucleic acid, and anthocyanins (Gangeshetty & Kumar, 2015).…”

mentioning

confidence: 99%

Efficacy and safety of Tripterygium wilfordii Hook. f. for oral lichen planus: Evidence from 18 randomized controlled trials

Luo

Kuai

Chen

et al. 2020

Phytotherapy Research

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Glycosides from the roots of Tripterygium wilfordii Hook. f. are used for the treatment of oral lichen planus (OLP), a chronic inflammatory disease affecting the oral mucosa. To investigate the effectiveness and safety of Tripterygium glycosides (TGs) for OLP treatment, we conducted a systematic review of 18 randomized controlled trials, comprising 1,339 participants, from international and Chinese databases. We evaluated outcomes of TGs alone or in combination with conventional treatments. In combination with topical glucocorticoids (TGCs), including triamcinolone acetonide and prednisone, the total effectiveness rate (risk ratio [RR], 1.17; 95% confidence interval [CI], 1.09–1.25; p < .00001), symptom score reducing index (mean difference [MD], −2.44; 95% CI, −3.12 to −1.77; p < .0001), and visual analog scale score (MD, −1.61; 95% CI, −2.22 to −1.00; p < .0001) were significantly improved. Patients treated with TGs combined with TGCs experienced lower recurrence rates (RR, 0.37; 95% CI, 0.18–0.76; p = 0.007). The occurrence of adverse events was not significantly different between the TGs groups and controls. The combination of TG and TGCs improved clinical efficacy and reduced recurrence without increasing the risk of adverse events. A high‐quality multicenter clinical study is needed to corroborate these findings.

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Oral lichenplanus: Etiology, pathogenesis, diagnosis, and management

Cited by 14 publications

References 55 publications

Detection of Hepatitis C Virus in Iraqi Patients With Oral Lichen Planus

Detection of Hepatitis C Virus in Iraqi Patients With Oral Lichen Planus

Desquamative Gingivitis as the Sole Manifestation in Oral Lichen Planus: Report of Case and Brief Literature Review

Efficacy and safety of Tripterygium wilfordii Hook. f. for oral lichen planus: Evidence from 18 randomized controlled trials

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