Oral lichen planus shows higher expressions of tumor suppressor gene products of p53 and p21 compared to oral mucositis. An immunohistochemical study

Safadi, Rima A.; Jaber, Sajida Zuhair Al; Hammad, Huda M.; Hamasha, Abed Al‐Hadi

doi:10.1016/j.archoralbio.2010.03.019

Cited by 35 publications

(44 citation statements)

References 30 publications

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“…Nevertheless, most of them found significantly higher expression in OLP than in normal oral mucosa [36]. As p53 expression has been identified as a response to DNA damage, [37] the identification of p53 in OLP tissue is interpreted as an indication of precancerous potential by some researchers [24, 38]. In support to this concept, Chaiyarit et al showed an i-NOS-dependent DNA damage and p53 elevated expression in OLP patients [39].…”

Section: The Role Of P53 In Olpmentioning

confidence: 99%

“…Another concept is that the high expression of p53 in OLP is a result of the higher cellular proliferation [22, 40]. To prove that p53 expression in OLP is not just a result of the inflammatory process, Safadi et al [38] compared the immunohistochemical expression of p53 and of its downstream effector p21 WAF1 between OLP and other inflammatory oral conditions and found significantly higher expression in OLP [38]. What is still unclear is the underlying mechanism that drives p53 expression in a significant percentage of OLP cases, but as p53 expression in OLP is comparable to that observed in dysplastic oral lesions, it is considered as a sign of malignant potential [36].…”

Section: The Role Of P53 In Olpmentioning

confidence: 99%

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Oral Lichen Planus as a Preneoplastic Inflammatory Model

Georgakopoulou

Achtari

Achtaris³

et al. 2012

Journal of Biomedicine and Biotechnology

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Oral lichen planus (OLP) is a chronic oral inflammatory disease of unknown etiology. According to reports, 1-2% of OLP patients develop oral squamous cell carcinoma (OSCC) in the long run. While World Health Organization (WHO) classifies OLP as “a potentially malignant disorder,” it is still a matter of debate which mechanisms drive OLP to such a condition. The current hypothesis connecting OLP and OSCC is that chronic inflammation results in crucial DNA damage which over time results in cancer development. Initial studies investigating the OLP and OSCC link were mainly retrospective clinical studies. Over the past years, several amount of information has accumulated, mainly from molecular studies on the OLP malignant potential. This article is a critical review of whether OLP has a malignant potential and, therefore, represents a model of preneoplastic inflammation.

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Section: The Role Of P53 In Olpmentioning

confidence: 99%

Section: The Role Of P53 In Olpmentioning

confidence: 99%

Oral Lichen Planus as a Preneoplastic Inflammatory Model

Georgakopoulou

Achtari

Achtaris³

et al. 2012

Journal of Biomedicine and Biotechnology

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“…According to Safadi et al (2010) some previous studies rate of developing cancer in OLP has been reported from 0.5-12.5% (Safadi et al, 2010). However, other studies failed to show potential malignization of OLP (Rödström et al, 2004;Brzak et al, 2012).…”

Section: Introductionmentioning

confidence: 98%

Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

Zargaran

Jamshidi²,

Eshghyar³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Oral lichen planus (OLP) is categorized as premalignant lesion although its malignant potential is a matter of controversy. The objective of this study was to investigate Ki67 expression in OLP, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC). Materials and Methods: Expression of Ki67 was evaluated through immunohistochemistry (IHC) in groups of A (17 cases of epithelial hyperplasia), B (16 cases of OLP), C1 (10 cases of mild epithelial dysplasia), C2 (10 cases of severe epithelial dysplasia), D1 (10 cases of well-differentiated OSCC), and D2 (10 cases of poorly-differentiated OSCC). Results: There was a significant difference in Ki67 expression based on quantitative analysis among the six studied groups as well as group B compared bilaterally with groups C2, D1 and D2 (p< 0.0001). However, there was no significant difference between groups B and C1 or between groups D1 and D2 (p> 0.05). Conclusions: Based on the results of the present study it may not be possible to definitely consider malignant transformation potential for OLP. However, expression of Ki67 was significantly higher in OLP than that of epithelial hyperplasia with no significant difference from that of mild epithelial dysplasia. This should be considered by clinicians to carefully and regularly follow up OLP lesions to detect potential subtle changes at an early stage.

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“…Due to the abnormal expression of certain oncogenes or anti-oncogenes in OLP, which serves as an indication of its risk of progression to cancer, the World Health Organization (WHO) has classified OLP as 'potentially malignant lesions' (1,4). It has been demonstrated that the carcinogenesis of OLP involves a combination of factors, which induce disorders of epithelial cell proliferation and apoptosis, and abnormalities of oncogenes, anti-oncogenes or certain signaling pathways, resulting in the malignant development of OLP (5)(6)(7). In recent years, the malignant potential of OLP has been controversial.…”

Section: Introductionmentioning

confidence: 99%

Expression of E-cadherin in oral lichen planus

2015

Experimental and Therapeutic Medicine

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Abstract. Oral lichen planus (OLP) is a common lesion of the oral mucosa that can progress to cancer. E-cadherin is involved in intercellular adherence and the pathogenesis, development and metastasis of tumors, and is considered to be an important indicator of tumor progression and prognosis. The aim of this study was to investigate the expression of E-cadherin in OLP in order to elucidate its role in the pathogenesis and malignant transformation of OLP and provide evidence to support the early diagnosis and treatment of OLP with malignant potential. OLP specimens (n=52) and samples of normal oral mucosa (n=41) as the control were collected. Immunohistochemical staining was conducted to reveal the expression of E-cadherin in the OLP samples and normal oral mucosa. It was observed that 25 of the 52 OLP specimens exhibited normal positive expression of E-cadherin and 27 exhibited abnormal positive expression, corresponding to an abnormal positive rate of 51.92%. In the normal oral mucosa group, 39 of the 41 cases exhibited normal positive expression and 2 exhibited abnormal positive expression. The abnormal positive rate in the normal oral mucosa was 4.88%, which was significantly lower than that in the OLP group. The significantly elevated rate of abnormal positive expression of E-cadherin in the OLP group indicates the involvement of E-cadherin in the malignant transformation of OLP and supports the malignant potential of OLP.

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Oral lichen planus shows higher expressions of tumor suppressor gene products of p53 and p21 compared to oral mucositis. An immunohistochemical study

Cited by 35 publications

References 30 publications

Oral Lichen Planus as a Preneoplastic Inflammatory Model

Oral Lichen Planus as a Preneoplastic Inflammatory Model

Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

Expression of E-cadherin in oral lichen planus

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