Oral lichen planus and chronic liver disease: A clinical and morphometric study of the oral lesions in relation to transaminase elevation

Jv, Bagan; Aguirre, J.Piñol; Olmo, Juan A. del; Milián, A; Peñarrocha, Miguel; Rodrigo, JoséM.; Cardona, Francisco

doi:10.1016/0030-4220(94)90065-5

Cited by 71 publications

(69 citation statements)

References 31 publications

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“…HCV viral sequences have been found in the serum in patients with LP (Jubert et al, 1994), and any of the three main HCV genotypes may be implicated (Pawlotsky et al, 1995a,b). HCV-RNA was found to be of high prevalence in a controlled study of 78 Spanish patients with erosive OLP (Sanchez-Perez et al, 1996), and several other reports have shown associations between HCV and LP (Bagan et al, 1994), on serological grounds. LP has been diagnosed in up to 5% of patients with HCV infection (Bagan et al, 1994), its onset can be related to HCV acquisition (Mokni et al, 1991), and a recent study indicated that up to 60% of OLP subjects with abnormal liver tests may be HCV-seropositive (Gandolfo et al, 1994).…”

Section: (3) Drugsmentioning

confidence: 80%

“…HCV-RNA was found to be of high prevalence in a controlled study of 78 Spanish patients with erosive OLP (Sanchez-Perez et al, 1996), and several other reports have shown associations between HCV and LP (Bagan et al, 1994), on serological grounds. LP has been diagnosed in up to 5% of patients with HCV infection (Bagan et al, 1994), its onset can be related to HCV acquisition (Mokni et al, 1991), and a recent study indicated that up to 60% of OLP subjects with abnormal liver tests may be HCV-seropositive (Gandolfo et al, 1994). There is also a higher prevalence of LP in patients with chronic HCV infection than in controls , and, at least in some countries, patients with OLP often have HCV infection (Nagao etal., 1995a).…”

Section: (3) Drugsmentioning

confidence: 80%

“…HCV may be associated with LP, at least in some countries of southern Europe (Bagan et al, 1994;Gandolfo et al, 1994) and in lapan (Nagao et al, 1995a). HCV viral sequences have been found in the serum in patients with LP (Jubert et al, 1994), and any of the three main HCV genotypes may be implicated (Pawlotsky et al, 1995a,b).…”

Section: (3) Drugsmentioning

confidence: 99%

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Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

471

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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Section: (3) Drugsmentioning

confidence: 80%

Section: (3) Drugsmentioning

confidence: 80%

See 1 more Smart Citation

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

471

461

View full text Add to dashboard Cite

show abstract

“…As they point out, OLP has been associated with a number of systemic disorders, generally of autoimmune origin (myasthenia gravis, Sjögren's syndrome, ulcerative colitis, psoriasis, celiac disease, some liver diseases, thymoma, and lupus erythematosus); however, only in a few conditions has this link been confirmed. [2][3][4][5][6] For example, the correlation between chronic hepatitis C virus (HCV) infection and OLP would be one of these, even if many contrasting results have been published, [7][8][9][10][11][12][13][14] and the partial dependency on geographic factors as well as genetic differences has been focused. 15,16 Furthermore, autoimmune conditions, such as systemic lupus erythematosus, rheumatoid arthritis, and celiac disease have also been simply found to be associated with autoimmune thyroid diseases, 17 but without great and definitive evidence.…”

Section: Association Of Oral Lichen Planus With Thyroid Disease In a mentioning

confidence: 99%

Association of oral lichen planus with thyroid disease in a Finnish population: A retrospective case-control study: “A different finding from a Mediterranean area”

Compilato¹,

Paderni²,

Fede³

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…However, the prevalence of anti-HCV antibodies in patients suffering from OLP ranged from 3.8 to 65%. 17 Although the relation has been detected all around the world but the geographical variations with strong positive associations is quite evident in the East, Southeast Asia, South America and Mediterranean countries. 18 Carrozzo et al reported association of HCV with OLP as distinct subset among LP and is particularly associated with HLA-DR6.…”

Section: Discussionmentioning

confidence: 98%

Oral lichen planus and hepatitis C virus infection; a symbiotic relationship or a mere co-incidence?

et al. 2018

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Background: Lichen planus (LP) is a common idiopathic chronic inflammatory immune mediated mucocutanous disease that effects stratified squamous epithelia and appendices. Hepatitis C virus (HCV) infection is quite common across the world. A couple of reports have suggested positive association of HCV infection and oral lichen planus (OLP) and most of the studies are usually confined to Mediterranean and south European countries. Due to high incidence and suspected alliance between these two diseases in Pakistan, the following study was conducted with the view that it may help clinicians to set guidelines for HCV testing of lichen planus patients.Methods: Approximately 11500 patients from general population coming to dental diagnostics department of Fatima Memorial Hospital, Lahore (from March 2015-February 2016) were screened clinically for OLP and by ELISA for HCV infection. Out of these 11500 patients 103 were selected one of them incidental and the other pre-diagnosed or both incidental and both pre-diagnosed. These patients were unaware but had either one or both OLP and HCV infection which was confirmed clinically and by ELISA respectively.Results: Majority of patients presenting for other dental complaints were unaware of these diseases process going on in them and was mostly an incidental finding by the clinician. Either one or both OLP and HCV infection were more conjoint in females comprising 77.7% of the total subjects. OLP alone was most common finding comprising 66.67% of the cases. HCV infection alone was present in 15.53% whereas 16.50% subjects showed presence of both OLP and HCV infection.Conclusions: The current study could not detect statistically significant relationship between OLP and HCV infection in Pakistani population which could be due to genetic variation or may be geographic relationship.

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Oral lichen planus and chronic liver disease: A clinical and morphometric study of the oral lesions in relation to transaminase elevation

Cited by 71 publications

References 31 publications

Update On Oral Lichen Planus: Etiopathogenesis and Management

Update On Oral Lichen Planus: Etiopathogenesis and Management

Association of oral lichen planus with thyroid disease in a Finnish population: A retrospective case-control study: “A different finding from a Mediterranean area”

Oral lichen planus and hepatitis C virus infection; a symbiotic relationship or a mere co-incidence?

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