Oral lichen planus: A retrospective study of 633 patients from Bucharest, Romania

Abstract

Objective: In this retrospective study, patients’ medical records were reviewed to investigate the profiles of 633 OLP cases in a group of Romania. Material and Methods: In this retrospective study, the following clinical data were obtained from the medical charts of patients: gender, age, clinical presentation of OLP, site affected, presence of symptoms, extraoral manifestations of lichen planus, presence of systemic diseases, and history of medications. Results: Most (78.67%) OLP patients were female and the mean age at presentation was 52 years. The white type of the disease (reticular/papular/plaque lesions) was the main form encountered in this sample (48.97%). Among patients with available hepatitis C virus test results, 9.6% were serum-positive. OLP was associated with gallbladder disease (i.e. cholecystitis, cholelithiasis) in 19% of patients. Six patients (0.95%) developed squamous cell carcinoma at a site with confirmed OLP lesions. Conclusions: To the best of our knowledge, no similar study has been conducted in a Romanian population. The present investigation revealed the predominance of OLP among middle-aged white women and the prevalence of bilateral involvement of the buccal mucosa with reticular white lesions. Anti-HCV circulating antibodies were more common in patients with OLP than in the general population and, notably, OLP was associated with gallbladder disease (cholecystitis, cholelithiasis) in 19% of patients. Key words:Oral lichen planus, oral mucosal diseases, retrospective study.

Clinicopathological profile and malignant transformation in oral lichen planus: A retrospective study

“…[34581516] Unilateral occurrence of lichen planus was observed in few of our cases, which clinically mimics another condition known as lichenoid reaction. Although they also show few similarities histopathologically, lichenoid reaction can be differentiated from lichen planus on the basis of subepithelial as well as diffuse infiltration of inflammatory infiltrate with substantial numbers of plasma cells, eosinophils, and neutrophils in contrast to only a subepithelial band of lymphocytes in the latter.…”

“…[34581617] However, Irani et al . reported erosive form to be the most common type in Iranian population.…”

Potentially malignant oral disorders and high‐risk habits in liver cirrhosis and lung cancer patients

“…Brzak et al () did a retrospective study on 12 508 patients with lichen and leukoplakia and during the period of 10 years did not find any malignant transformation in patients with lichen. On the other hand, Tovaru et al (), in an another retrospective study, of 633 patients with lichen, after 0.5–20 years after its diagnosis, found six cases of OSCC at the site of previously confirmed lichen. The percentage (0.95%) is not big, but has to be taken into account.…”

Oral Erosive Lichen Planus - A Case Report with a Highlight on Etiopathogeneses and Immunomodulatory Effect of Tacrolimus in Management of Oelp

“…As an adjunct to therapy, patients should also be advised of the need to maintain a high standard of oral hygiene and any causes of mucosal trauma such as ill fitting dentures, sharp cusps and poor dental restorations should be eliminated. Patients should be informed that there is a very small risk of malignancy associated with oral lichen planus and that long term monitoring is appropriate [10].…”