Oral lichen planus: a condition with more persistence and extra‐oral involvement than suspected?

Bidarra, M; Buchanan, John; Scully, Crispian; Moles, David R; Porter, Stephen

doi:10.1111/j.1600-0714.2008.00703.x

Cited by 21 publications

(3 citation statements)

References 28 publications

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“…This audit provides insight into current U.K. medical practice for the management and treatment response of a large cohort of patients with ELPV. Patient demographics were consistent with previous studies that have found that ELPV is most common in women of menopausal age 3,7,8 and follows a chronic course, 9 with half of our patient cohort experiencing disease lasting 5 years or longer.…”

Section: Discussionsupporting

confidence: 89%

Real-life experience of managing vulval erosive lichen planus: a case-based review and U.K. multicentre case note audit

Simpson

Littlewood

Cooper

et al. 2012

British Journal of Dermatology

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Section: Discussionsupporting

confidence: 89%

Real-life experience of managing vulval erosive lichen planus: a case-based review and U.K. multicentre case note audit

Simpson

Littlewood

Cooper

et al. 2012

British Journal of Dermatology

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“…The OLP lesions may coexist with cutaneous and genital lesions, or may be the only disease manifestations [2]. The epidemiology of OLP is not easy to calculate with reported incidence ranging between 1-2% of the general population.…”

Section: Introductionmentioning

confidence: 99%

Oral Lichen Planus as a Preneoplastic Inflammatory Model

Georgakopoulou

Achtari

Achtaris³

et al. 2012

Journal of Biomedicine and Biotechnology

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Oral lichen planus (OLP) is a chronic oral inflammatory disease of unknown etiology. According to reports, 1-2% of OLP patients develop oral squamous cell carcinoma (OSCC) in the long run. While World Health Organization (WHO) classifies OLP as “a potentially malignant disorder,” it is still a matter of debate which mechanisms drive OLP to such a condition. The current hypothesis connecting OLP and OSCC is that chronic inflammation results in crucial DNA damage which over time results in cancer development. Initial studies investigating the OLP and OSCC link were mainly retrospective clinical studies. Over the past years, several amount of information has accumulated, mainly from molecular studies on the OLP malignant potential. This article is a critical review of whether OLP has a malignant potential and, therefore, represents a model of preneoplastic inflammation.

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“…However, this association should be interpreted with caution. Since OLP is a chronic condition with periods of exacerbation and remission, it may cause discomfort or pain and difficulty in eating and drinking [20][21][22]. A study on dietary changes in 48 patients with oral vesiculoulcerative diseases, of whom most were diagnosed with OLP, showed that even patients with mild forms of the disease would change their eating habits for extended periods, which might negatively affect the patients' nutritional status [22].…”

Section: Discussionmentioning

confidence: 99%

The profile of hematinic deficiencies in patients with oral lichen planus: a case-control study

et al. 2020

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Background Oral lichen planus (OLP) is a relatively common mucocutaneous disorder, and its causative factors and pathogenesis are not fully understood. Existing studies on the association between hematinic deficiencies and OLP are limited and inconsistent. The aim of this study was to assess the hematinic deficiencies in a cohort of OLP patients and evaluate the correlation between hematinic deficiencies and OLP. Methods A total of 236 OLP patients and 226 age-and-gender-matched healthy controls were enrolled in this study. The levels of hemoglobin (Hb), serum folate, vitamin B12 and ferritin were measured and compared between OLP patients and healthy controls. An REU (reticular/hyperkeratotic, erosive/erythematous, ulcerative) scoring system was adopted and compared between the OLP patients with and without hematinic deficiencies. The correlation between hematinic deficiencies and OLP was analyzed. Results The frequencies of serum ferritin and vitamin B12 deficiency in OLP patients were both significantly higher than those of the healthy controls. According to gender and age, the profiles of hematinic deficiencies in OLP patients were significantly different. As for the REU score, no significant difference existed between OLP patients with and without hematinic deficiencies. Both serum ferritin deficiency and serum vitamin B12 deficiency were significantly correlated with OLP. Conclusions The present study suggested a significant association between hematinic deficiencies and OLP. Iron, folate, and vitamin B12 levels in OLP patients should be monitored routinely. Further studies are warranted to explore the interactions between OLP and hematinic deficiencies.

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Oral lichen planus: a condition with more persistence and extra‐oral involvement than suspected?

Abstract: The survey results suggest that in patients with oral lichen planus oral lesions persist for a prolonged period, and that extra-oral lesions may be more common than suspected. However, further studies involving specialists to examine extra-oral sites are required.

Cited by 21 publications

References 28 publications

Real-life experience of managing vulval erosive lichen planus: a case-based review and U.K. multicentre case note audit

Real-life experience of managing vulval erosive lichen planus: a case-based review and U.K. multicentre case note audit

Oral Lichen Planus as a Preneoplastic Inflammatory Model

The profile of hematinic deficiencies in patients with oral lichen planus: a case-control study

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