Oral Lesion as the first Clinical Presentation in Sarcoidosis: A Case Report

Abstract

Sarcoidosis is a common multi-system disease characterized histolopathologically by the formation of non-caseating granulomas in the affected tissues. The oral involvement of sarcoidosis is relatively rare with less than 70 reported cases in literature while an oral lesion as the initial presenting sign is even less common. Oral lesions of sarcoidosis may mimic the lesions of other serious systemic diseases including Crohn's disease and tuberculosis as well as lesions localized to the orofacial region such as orofacial granulomatosis. This report presents a case of non-progressive sarcoidosis where the initial presenting symptom was a lesion in the buccal vestibule attached to the gingivae. A brief review of the pathology and clinical features is also presented.

Oral sarcoidosis: a case report and review of the literature

“…The gingiva and oral mucosa are rarely affected by sarcoidosis . Only about 70 cases of oral sarcoidosis have been reported . The oral lesions may be solitary or multiple and are sometimes the first manifestation of sarcoidosis, though in most cases they develop only after sarcoidosis has already been diagnosed.…”

“…Only about 70 cases of oral sarcoidosis have been reported . The oral lesions may be solitary or multiple and are sometimes the first manifestation of sarcoidosis, though in most cases they develop only after sarcoidosis has already been diagnosed. Affected oral sites are the buccal mucosa, gingiva, lip, hard palate and tongue …”

“…Histopathologically, it is characterized by non‐caseating inflammatory granulomata . In fact, any region including the oral mucosa may be affected …”

Cutaneous Sarcoidosis

“…95 Mucosal disease Oral involvement of sarcoidosis is rare and morphologically can simulate cutaneous diseases with the presence of papules; nodules; erythema, including strawberry gums; and ulcerations. [100][101][102][103] Any portion of the oral cavity can be affected, and this can be the presenting sign of systemic disease. 102 Within the oral cavity, the buccal mucosa, gingiva, lips, tongue, and floor of mouth were most commonly affected, followed Cutaneous Sarcoidosis by the palate and submandibular glands.…”

“…[100][101][102][103] Any portion of the oral cavity can be affected, and this can be the presenting sign of systemic disease. 102 Within the oral cavity, the buccal mucosa, gingiva, lips, tongue, and floor of mouth were most commonly affected, followed Cutaneous Sarcoidosis by the palate and submandibular glands. 103 Genital involvement in sarcoidosis also is rare and can present as infiltrative plaques, nodules, masses, or swelling in these areas.…”