Oral ketamine and midazolam for pediatric burn patients: A prospective, randomized, double-blind study

Norambuena, Claudia; Yañez, Jaqueline; Flores, Viviana; Puentes, Pamela; Carrasco, Patricia Ribas; Villena, Rodolfo

doi:10.1016/j.jpedsurg.2012.08.018

Cited by 44 publications

(33 citation statements)

References 20 publications

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“…A meta-analysis demonstrated that ketamine reduced the amount of opioid used versus placebo after surgery (Laskowski et al, 2011), and an open-label study showed superior analgesia for out-of-hospital trauma pain when IV ketamine was added to IV morphine therapy compared with IV morphine therapy alone (Jennings et al, 2012). In addition, a double-blind study demonstrated a benefit of oral ketamine and midazolam versus oral acetaminophen, midazolam, plus codeine in pediatric burn patients (Norambuena et al, 2013). …”

Section: Resultsmentioning

confidence: 99%

Exploring Opioid-Sparing Multimodal Analgesia Options in Trauma: A Nursing Perspective

Sullivan

Lyons

Montgomery

et al. 2016

Journal of Trauma Nursing

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Section: Resultsmentioning

confidence: 99%

Exploring Opioid-Sparing Multimodal Analgesia Options in Trauma: A Nursing Perspective

Sullivan

Lyons

Montgomery

et al. 2016

Journal of Trauma Nursing

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“…Nielsen [73] suggested that a sufentanil and ketamine nasal spray provides a rapid onset of analgesia for a variety of painful procedures with few adverse effects and has promising features for use in pediatric procedural pain management. A prospective, randomized, double-blind study that included patients from 1 to 5 years old, with burn areas up to 10% of total body surface area that required bedside wound care, showed that the combination of oral midazolam and ketamine provided better analgesia than the combination of midazolam, acetaminophen, and codeine [74] . Conversely, a different study did not support the use of perioperative low-dose ketamine to decrease opioid use in children with scoliosis undergoing posterior spinal fusion [75] .…”

Section: Pediatric Usementioning

confidence: 99%

Ketamine use in current clinical practice

2016

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After nearly half a century on the market, ketamine still occupies a unique corner in the medical armamentarium of anesthesiologists or clinicians treating pain. Over the last two decades, much research has been conducted highlighting the drug's mechanisms of action, specifically those of its enantiomers. Nowadays, ketamine is also being utilized for pediatric pain control in emergency department, with its anti-hyperalgesic and anti-inflammatory effects being revealed in acute and chronic pain management. Recently, new insights have been gained on ketamine's potential anti-depressive and antisuicidal effects. This article provides an overview of the drug's pharmacokinetics and pharmacodynamics while also discussing the potential benefits and risks of ketamine administration in various clinical settings.

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“…Inspiration was found in the literature where oral ketamine and midazolam was recommended, but also at a risk of long time consequences 11 12…”

Section: Discussionmentioning

confidence: 99%

Newborn with severe epidermolysis bullosa: to treat or not to treat?

et al. 2016

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Epidermolysis bullosa (EB) is an inherited skin disease with four main subtypes that cannot be distinguished clinically at birth. All subtypes may present with widespread life-threatening blisters and fragile skin, making treatment and handling of the newborn with EB challenging. The prognosis of EB depends on the subtype, and therefore maximum treatment is necessary until the final diagnosis is known. In this case, it took 2 weeks before a final diagnosis was reached. In the meantime, we had several ethical discussions on the treatment level. The most important issues were management of pain and nutrition. For immediate pain relief, intranasal fentanyl worked best and gabapentin was successfully used for chronic pain. The feeding difficulties were handled first by a nasogastric feeding tube. Later a normal feeding bottle proved to be adequate.

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Oral ketamine and midazolam for pediatric burn patients: A prospective, randomized, double-blind study

Cited by 44 publications

References 20 publications

Exploring Opioid-Sparing Multimodal Analgesia Options in Trauma: A Nursing Perspective

Exploring Opioid-Sparing Multimodal Analgesia Options in Trauma: A Nursing Perspective

Ketamine use in current clinical practice

Newborn with severe epidermolysis bullosa: to treat or not to treat?

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