Oral juvenile xanthogranuloma in a child: Clinical, histological and immunohistochemical profile of a rare entity

Sánchez‐Romero, Celeste; Arriaga, Ana Isabel Cuenca; Almeida, Oslei Paes de; Cortés, Evangelina Gutiérrez

doi:10.1111/cup.13152

Cited by 8 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, Langerhans cell sarcomas usually demonstrate cells with nuclear pleomorphism and a high proliferation index measured by Ki-67 expression. 32 Other non-Langerhans cells proliferative histiocytic disorders that eventually show a morphological pattern similar to LCH are promptly ruled out by negativity for CD-207, 17,33,34…”

Section: Immunohistochemical Findingsmentioning

confidence: 99%

Langerhans cell histiocytosis in the oral and maxillofacial region: An update

Faustino

Fernandes

Pontes

et al. 2021

J Oral Pathology Medicine

View full text Add to dashboard Cite

Langerhans cells (LC) are a group of antigen-presenting, migratory and non-proliferative cells belonging to a group of leukocytes called dendritic cells (DC). In normal scenarios, LC is found in the suprabasal layer of the epidermis and in bronchial, urogenital, and oropharyngeal mucosas. 1 Langerhans cell histiocytosis (LCH) is a condition characterized by abnormal proliferation and infiltration of marrow-derived LC that may be diagnosed in oral and maxillofacial tissues. 2,3 Therefore, the aim of the present report was to describe the main characteristics of this uncommon disease, with emphasis on its clinical manifestations, microscopic features, and the therapeutic approaches currently available. This study forms part of a special issue published by the Journal of Oral Pathology and Medicine covering the most important aspects of hematolymphoid lesions and neoplasms affecting the oral cavity and neighboring structures. | OVERVIE WThe first case of LCH was described by Hand in 1893. 4 More than hundred years later, LCH still challenges physicians from the diagnosis to treatment due to reasons such as the rare occurrence of this condition and its broad clinical manifestations. 5 Following the first description, LCH was called as monocyte-macrophage system disease because of the identification of histiocyte-like cells in affected tissues. In this respect, Hand-Schuller-Christian syndrome, Letterer-Siwe disease,

show abstract

Section: Immunohistochemical Findingsmentioning

confidence: 99%

Langerhans cell histiocytosis in the oral and maxillofacial region: An update

Faustino

Fernandes

Pontes

et al. 2021

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…Compared to the majority of cutaneous JXG cases occurring before the age 1, only 14% of the oral JXG cases were diagnosed in the 1st decade 1,7,18) . Oral JXG has been observed at the tongue, gingiva, palate, lips, and buccal mucosa 13,18) . Near to 90% of oral JXG cases are solitary, and systemic JXG has not been reported in oral JXG 18) .…”

Section: ⅱ Case Reportmentioning

confidence: 99%

“…Surgical excision is required, and incomplete removal can lead to recurrence 13) . Oral JXG has been reported to have a recurrence rate of 14% 18) .…”

Section: ⅱ Case Reportmentioning

confidence: 99%

See 1 more Smart Citation

Gingival Juvenile Xanthogranuloma

Kim¹,

Han²,

Yang³

et al. 2019

Korean J. Oral Maxillofac. Pathol.

View full text Add to dashboard Cite

Juvenile xanthogranuloma (JXG) is a rare non-Langerhans type histiocytosis, that arises in the 1 st and 2 nd decade 1) . JXG has been earlier referred to as nevoxanthoendothelioma, because this xanthoma complex displayed as circumscribed, colored, chronic skin lesions composed of oval endotheliallike cells with various ranges of vascularity 2,3) . It was later classified as a benign histiocytic disorder most likely of dermal dendritic cell origin, but the specific histiocytic lineage is still controversial [4][5][6] .JXG is a pediatric disease with 45~71.0% of the cases diagnosed before the age 1 1,7) . The majority of JXG are cutaneous lesions. It is most common in the head and neck region, closely followed by the extremities and trunk 1,7,8) . Over 80% of the cutaneous JXG cases are solitary with a nearly 1:1 sex ratio, male being slightly more prevalent 1,7) .Whereas in multiple cutaneous lesions, 9 in 10 are male 1) . Extracutaneous lesions, especially those without a concurrent cutaneous lesion are extremely rare and have been seen most commonly in the submucosa and bone of the head and neck. Systemic visceral involvement may accompany the cutaneous lesions and are seen in the central nervous system, eye, lung, liver, pancreas, spleen, kidney, intestines and others 1,7,9,10) . Lesions are well circumscribed, firm nodules

show abstract

“…JXG has been characterized by two main clinical forms including a micronodular form with multiple small papules on the body upper part and also a macronodular form with one or few larger nodules on the head and trunk . JXG could present in an extensive shapes and sizes range, as well as locations and distributions, and has been reported as different clinical appearances including oral mucosal form, hyperkeratotic nodule, multiple giants, generalized lichenoid eruption, reticulated maculopapular eruption, cluster form, and finally rare cases of cutaneous horn‐like …”

Section: Introductionmentioning

confidence: 99%