Oral juvenile xanthogranuloma: An unusual presentation in an adult patient and a systematic analysis of published cases

Solitary xanthoma affecting the oral mucosa: Immunohistochemical analysis and literature review

“…JXG is a histiocytic disorder with frequent cutaneous involvement. [14][15][16] Microscopically, JXG exhibits a proliferation of histiocytes with a foamy, eosinophilic, and vacuolated cytoplasm, often admixed with Touton-type giant cells. However, when xanthomatous cells and Touton-type giant cells are absent, it can be challenging to accurately diagnose JXG as the presentation can mimic malignant tumors.…”

“…17,18 To date, 38 cases of intraoral JXG have been reported. 14,15 Of those, seven cases involved adult patients, with ages varying between 35 and 64 years. 14,15 Clinically, three variants of oral JXG have been described, namely, the papular, nodular, and giant or macronodular forms.…”

“…14,15 Of those, seven cases involved adult patients, with ages varying between 35 and 64 years. 14,15 Clinically, three variants of oral JXG have been described, namely, the papular, nodular, and giant or macronodular forms. Notably, case studies on four children and two adults have described two histopathological variants (non-lipidized and mononuclear).…”

“…Notably, case studies on four children and two adults have described two histopathological variants (non-lipidized and mononuclear). 14,16,19,20 The variants are characterized by the absence (or inconspicuousness) of foam cells and Touton-type giant cells. Unlike the mononuclear variant (n = 5), the non-lipidized variant (n = 1) exhibited a histiocytic infiltrate with a high mitotic index.…”

“…JXG is a histiocytic disorder with frequent cutaneous involvement 14–16 . Microscopically, JXG exhibits a proliferation of histiocytes with a foamy, eosinophilic, and vacuolated cytoplasm, often admixed with Touton‐type giant cells.…”