Oral isotretinoin and haemophilia A

Bettoli, Vincenzo; Pizzigoni, Stefania; Vasina, S V; Mancino, Anne T.

doi:10.1111/j.1468-3083.2004.01062.x

Cited by 3 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The second case of hemophilia A using isotretinoin was reported by Bettoli et al in 2004. In this second case, isotretinoin was reported to have had no exacerbating effect on bleeding (8). The other reports about increased bleeding tendency were related to thrombocyte abnormalities.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Effect of isotretinoin on prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT)

Kaptanoğlu

Uncu

Özyurt³

et al. 2012

Journal of Dermatological Treatment

View full text Add to dashboard Cite

Patients with severe acne may need elective/urgent surgical interventions during treatment with isotretinoin and it is critical for the surgeon to consider the possible effects of this medication on coagulation systems. The aim of this study is to determine the changes in prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT) during isotretinoin treatment. PT, aPTT, and INR values of 51 severe acne patients were evaluated during routine pre-treatment biochemical analysis. Only patients with normal values were included in the study. The results of before and after 1 month treatment were compared statistically. There were no statistically significant change in mean alanine aminotranferease (ALT), aspartate aminotransferase (AST), PT, and INR values after treatment. A significant increase in aPTT was detected. The INR values, which are more trusted and safe, showed no difference. Isotretinoin seems to have no effect on these coagulation parameters.

show abstract

Section: Discussionmentioning

confidence: 92%

“…Dootson et al reported the first case with exacerbation of bleeding tendency in a patient with hemophilia, during isotretinoin treatment in 1992 (7). The second case of hemophilia A using isotretinoin was reported by Bettoli et al in 2004. In this second case, isotretinoin was reported to have had no exacerbating effect on bleeding (8).…”

Section: Discussionmentioning

confidence: 93%

Effect of isotretinoin on prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT)

Kaptanoğlu

Uncu

Özyurt³

et al. 2012

Journal of Dermatological Treatment

View full text Add to dashboard Cite

show abstract

“…et al found that oral isotretinoin may accelerate fibrinolysis and disturbed coagulation factors (12). Thus it is essential and mandatory to continuous monitoring of coagulation cascade very closely in patients with chronic use of drugs in the treatment of chronic illness (13). Actually, the present study was designed for in vitro evaluating the direct effect of some widely prescribed intravenous drugs on coagulation hemostasis explained by PT, APTT and INR.…”

Section: Introductionmentioning

confidence: 96%

Impact of some intravenously administered drugs (paracetamol, hydrocortisone, dexamethasone and amikacin) on coagulation hemostasis (in vitro evaluation study)

2019

View full text Add to dashboard Cite

Background: Normally, the coagulation homeostasis prevents bleeding and retain the blood in the vascular system during periods of injury. Unfortunately, pathological factors, drugs or toxins could affect one or more stages of homeostasis mechanisms leading to bleeding or abnormal thrombi. Evaluation of prothrombin time is a favorable test for the screening of extrinsic coagulation mechanism whilst activated partial thromboplastin time measurement is a global coagulation screening method for intrinsic factor. Material and Methods: Blood samples were withdrawn from healthy adults volunteers for clotting times measurements from collected plasma. The effect of paracetamol, hydrocortisone, dexamethasone, and amikacin at different concentrations on coagulation homeostasis was in vitro investigated and compared to control and positive control. Results: High concentrations of all tested drugs except amikacin prolong significantly activated partial thromboplastin time, whilst the effect on the prothrombin time was conflicting. Conclusions: Paracetamol, hydrocortisone, dexamethasone, and amikacin could prolong clotting time expressed in prolongation of activated partial thromboplastin time comparable to the anticoagulants drugs.

show abstract

Idiosyncratic Reaction of Isotretinoin: A Review

Lee,

Chan,

Lee

et al. 2024

Dermatological Reviews

View full text Add to dashboard Cite

BackgroundIsotretinoin is widely recognized for its efficacy in treating severe acne. However, its use is associated with a variety of idiosyncratic reactions that can affect multiple organ systems and bodily functions, necessitating vigilant monitoring and appropriate management.ObjectivesThe aim of this review is to raise awareness of the broad spectrum of adverse effects linked to isotretinoin therapy, thereby enhancing the ability of healthcare providers to identify at‐risk individuals and improve patient outcomes.MethodsA comprehensive review of current literature was conducted to explore the range of idiosyncratic reactions associated with isotretinoin. The focus was on identifying the types of adverse effects reported and the necessary monitoring strategies to mitigate these risks.ResultsIsotretinoin has been linked to a wide array of adverse effects, including, but not limited to, psychiatric issues (e.g., depression and suicidal behavior), hematological complications (e.g., neutropenia and agranulocytosis), gastrointestinal disturbances, cardiovascular effects, dermatological manifestations, hepatobiliary issues, ophthalmological changes, and orthopedic concerns. These reactions highlight the importance of careful patient monitoring during isotretinoin therapy.ConclusionHealthcare professionals prescribing isotretinoin must be aware of the potential for diverse idiosyncratic reactions and should implement appropriate monitoring protocols to ensure patient safety. By understanding and anticipating these adverse effects, healthcare providers can better manage the risks associated with isotretinoin use, ultimately improving the quality of care for patients undergoing treatment for severe acne.

show abstract

Oral isotretinoin and haemophilia A

Cited by 3 publications

References 10 publications

Effect of isotretinoin on prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT)

Effect of isotretinoin on prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT)

Impact of some intravenously administered drugs (paracetamol, hydrocortisone, dexamethasone and amikacin) on coagulation hemostasis (in vitro evaluation study)

Idiosyncratic Reaction of Isotretinoin: A Review

Contact Info

Product

Resources

About