Oral isoniazid causes oxidative stress, oocyte deterioration and infertility in mice

Qiao, Peipei; Zhang, Yingbin; Yang, Ying; Meng, Ru; Xu, Zhiming; Jiang, Xianlei; Zhang, Yong; Zhang, Chengtu; Su, Jianmin

doi:10.1016/j.tox.2021.152749

Cited by 7 publications

(2 citation statements)

References 52 publications

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“…Furthermore, an increase in the expression of key CRGs could lead to infertility in patients with EMT. Qiao et al showed that isoniazid activates the Keap1/Nrf2 signaling pathway by inducing oxidative stress and apoptosis, thereby impairing the reproductive system and reducing fertility in mammals [22]. Ivanov et al showed that melatonin could protect the developing embryo from oxidative stress by modulating NFE2L2, SOD1, and GPX1 expression [23].…”

Section: Discussionmentioning

confidence: 99%

Machine Learning Algorithms for a Novel Cuproptosis-related Gene Signature of Diagnostic and Immune Infiltration in Endometriosis

Wang

Ling

et al. 2023

Preprint

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Endometriosis (EMT) is a chronic hormone-dependent disease where in viable endometrial tissue is transplanted outside the uterus. Interestingly, immune infiltration is significantly involved in EMT pathogenesis. Currently, no studies have shown the involvement of cuproptosis-related genes (CRGs) in regulating immune infiltration in EMT. This study identified three CRGs such as GLS, NFE2L2, and PDHA1, associated with EMT using machine learning algorithms. These three CRGs were upregulated in the endometrium of patients with moderate/severe EMT and downregulated in patients with infertility. Single sample genomic enrichment analysis (ssGSEA) revealed that these CRGs were closely correlated with autoimmune diseases such as systemic lupus erythematosus. Furthermore, these CRGs were correlated with immune cells such as eosinophils, natural killer cells, and macrophages. Therefore, profiling patients based on these genes aid in a more accurate diagnosis of EMT progression. These findings provide a new idea for the pathology and treatment of endometriosis, suggesting that CRGs such as GLS, NFE2L2, and PDHA1 may play a key role in the occurrence and development of endometriosis.

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Section: Discussionmentioning

confidence: 99%

Machine Learning Algorithms for a Novel Cuproptosis-related Gene Signature of Diagnostic and Immune Infiltration in Endometriosis

Wang

Ling

et al. 2023

Preprint

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“…The Kelch-like ECH-associated protein 1 (Keap1) counteracts the effect of NRF2 by contributing to its degradation by ubiquitin proteasomes [177]. In vitro exposure to isoniazid in mice oocytes led to an increase in ROS and to the activation of the OS-response pathway Keap1-NRF2 [178]. Similarly, in vitro exposure to OS resulted in an up-regulation of NRF2 expression and its downstream antioxidant genes in preimplantation bovine embryos at different times of development (8-cell, 16-cell, and blastocyst stage embryos).…”

mentioning

confidence: 99%

Oxidative Stress and Assisted Reproduction: A Comprehensive Review of Its Pathophysiological Role and Strategies for Optimizing Embryo Culture Environment

et al. 2022

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Oxidative stress (OS) due to an imbalance between reactive oxygen species (ROS) and antioxidants has been established as an important factor that can negatively affect the outcomes of assisted reproductive techniques (ARTs). Excess ROS exert their pathological effects through damage to cellular lipids, organelles, and DNA, alteration of enzymatic function, and apoptosis. ROS can be produced intracellularly, from immature sperm, oocytes, and embryos. Additionally, several external factors may induce high ROS production in the ART setup, including atmospheric oxygen, CO2 incubators, consumables, visible light, temperature, humidity, volatile organic compounds, and culture media additives. Pathological amounts of ROS can also be generated during the cryopreservation-thawing process of gametes or embryos. Generally, these factors can act at any stage during ART, from gamete preparation to embryo development, till the blastocyst stage. In this review, we discuss the in vitro conditions and environmental factors responsible for the induction of OS in an ART setting. In addition, we describe the effects of OS on gametes and embryos. Furthermore, we highlight strategies to ameliorate the impact of OS during the whole human embryo culture period, from gametes to blastocyst stage.

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Oxidative stress

Boutros¹,

Ray²

2024

Encyclopedia of Toxicology

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Oral isoniazid causes oxidative stress, oocyte deterioration and infertility in mice

Cited by 7 publications

References 52 publications

Machine Learning Algorithms for a Novel Cuproptosis-related Gene Signature of Diagnostic and Immune Infiltration in Endometriosis

Machine Learning Algorithms for a Novel Cuproptosis-related Gene Signature of Diagnostic and Immune Infiltration in Endometriosis

Oxidative Stress and Assisted Reproduction: A Comprehensive Review of Its Pathophysiological Role and Strategies for Optimizing Embryo Culture Environment

Oxidative stress

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