Oral iron supplementation leads to oxidative imbalance in anemic women: A prospective study

Tiwari, Amit; Mahdi, Abbas Ali; Chandyan, Sudarshna; Zahra, Fatima; Godbole, Madan M.; Jaiswar, Shyam Pyari; Srivastava, Vinod K.; Negi, Mahendra Pal Singh

doi:10.1016/j.clnu.2010.08.001

Cited by 36 publications

(30 citation statements)

References 26 publications

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“…According to oxidative theory, elevated levels of either of these pose a health risk [17]. SF is an acute phase reactant and can be increased under inflammatory conditions.…”

Section: Discussionmentioning

confidence: 99%

Diet, iron biomarkers and oxidative stress in a representative sample of Mediterranean population

Romeu

Aranda

Giralt

et al. 2013

Nutr J

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BackgroundThe consumption pattern characterized by high consumption of vegetables, fruit, fish, olive oil and red wine has been associated with improvements in the total antioxidant capacity of individuals and reduced incidence of diseases related to oxidation. Also, high body iron levels may contribute to increase the oxidative stress by the generation of reactive oxygen species. The objective of this study is to analyze the relationship between antioxidant and pro-oxidant factors obtained from the diet and iron biomarkers on lipoprotein oxidation and total antioxidant capacity in a representative sample of the Mediterranean population.MethodsCross-sectional prospective study, carried out with 815 randomly selected subjects (425 women and 390 men). Dietary assessment (3-day food records), iron biomarkers (serum ferritin, serum iron and transferrin saturation), biochemical markers of lipoperoxidation (TBARS), antioxidant capacity (ORAC) and CRP (C-Reactive Protein) were determined. Multiple Linear Regression (MLR) models were applied to analyze the association between diet factors and iron biomarkers on TBARS and ORAC levels.ResultsWe observed that lipoperoxidation measured by TBARS increased by age but no differences were observed by sex. Antioxidant capacity measured by ORAC is independent of age and sex. In general, increasing age, tobacco, heme iron intake from meat and fish and transferrin saturation were independently and positively associated with TBARS, while non-heme iron was negatively associated. Vegetables, vitamin C intake and serum ferritin were positively associated with ORAC, whereas saturated fatty acids and meat intake were negatively associated.ConclusionsIn our general population, we observed that oxidative stress is related to aging, but antioxidant capacity is not. The highest intake of dietary non-heme iron, vegetables and vitamin C intake exerts a protective effect against oxidation while the highest intake of dietary heme iron from meat and fish and saturated fatty acids are associated with increased oxidative stress. High levels of circulating iron measured by transferrin saturation are associated with increased oxidative stress in women however its association with the higher levels of serum ferritin is controversial.

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“…According to oxidative theory, elevated levels of either of these pose a health risk [17]. SF is an acute phase reactant and can be increased under inflammatory conditions.…”

Section: Discussionmentioning

confidence: 99%

Diet, iron biomarkers and oxidative stress in a representative sample of Mediterranean population

Romeu

Aranda

Giralt

et al. 2013

Nutr J

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“…Elevated iron levels have been associated with several chronic diseases such as cardiovascular disease [1], metabolic syndrome [2], type 2 diabetes [3], cancer [4] as well as neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) [5]. It has been speculated that these relationships are mediated by oxidative stress, a condition characterized by an imbalance between the generation of reactive oxygen species (ROS) and response from the antioxidant defence systems [6] In fact, certain pathologies, characterized by iron excess, such as b-thalassaemia [7] or hereditary haemochromatosis (HH) [8], have been associated with increased oxidative stress. Importantly, in a case-control study, HH subjects showed significant higher oxidative stress degree compared to healthy controls at baseline whereas these differences disappeared after phlebotomy treatment [8].…”

Section: Introductionmentioning

confidence: 99%

Increased iron levels and lipid peroxidation in a Mediterranean population of Spain

Aranda

Fernández‐Cao

Tous

et al. 2016

Eur J Clin Investigation

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“…A number of recent studies suggest that Fe provided in excess may induce oxidative stress through the production of reactive oxygen species. Supplementation of 100 mg Fe/d to mildly anaemic women resulted in an increase in oxidative stress (2) , while a dose of 50 mg/d given in the second trimester to pregnant women with high Hb (≥135 g/l) resulted in a higher number of babies born small for gestational age and a higher incidence of hypertensive disorders (3) . Intra-uterine oxidative stress is associated with adverse birth outcomes such as intrauterine growth restriction, pre-eclampsia and an elevated risk of premature rupture of membranes (4) , as well as an elevated risk of metabolic syndrome in later life (5) .…”

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confidence: 99%

Oxidative stress during early pregnancy and birth outcomes

Shastri

Pammal

Mani

et al. 2016

Public Health Nutr.

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Objective: Routine high-dose Fe supplementation in non-anaemic pregnant women may induce oxidative stress and eventually affect birth outcomes. The aim of the present study was to measure oxidative stress markers in pregnant women with low/normal and high Hb values in trimester 1 (Hb 1 ) and to relate these to birth weight. Design: A cross-sectional study where selected oxidative stress markers were analysed in both maternal (trimester 1; T1) and cord blood samples and correlated with birth weight. Setting: A tertiary hospital in urban South India. Subjects: One hundred women were chosen based on their Hb 1 values (forty women with low/normal Hb 1 (<110 g/l) and sixty women with high Hb 1 (≥120 g/l)). Results: In T1, women with high Hb 1 values were found to have lower paraoxonase-1 (PON-1) activity (424·7 (SD 163·7) v. 532·9 (SD 144·7) pmol p-nitrophenol formed/min per ml plasma, P = 0·002) and higher lipid peroxides compared with women with low/normal Hb 1 . Routine supplementation of Fe to these women resulted in persistent lower PON-1 activity in cord blood (P = 0·02) and directionally lower (P = 0·142) birth weights. Furthermore, women with high Hb 1 who delivered low-birth-weight babies were observed to have lowest PON-1 activity in T1. No changes were observed in other markers (myeloperoxidase activity and total antioxidant levels). Conclusions: Routine Fe supplementation in pregnant women with high Hb 1 associated with increased oxidative stress, as reflected by low PON-1 activity in T1, could potentially lead to deleterious effects on birth weight.

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Oral iron supplementation leads to oxidative imbalance in anemic women: A prospective study

Cited by 36 publications

References 26 publications

Diet, iron biomarkers and oxidative stress in a representative sample of Mediterranean population

Diet, iron biomarkers and oxidative stress in a representative sample of Mediterranean population

Increased iron levels and lipid peroxidation in a Mediterranean population of Spain

Oxidative stress during early pregnancy and birth outcomes

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